Radiotherapy Treatment For Prostate Cancer - A Change In Practice Based On Direct Evidence For Targeting And Toxicity Effects Using Real Outcomes Data
Funder
National Health and Medical Research Council
Funding Amount
$555,129.00
Summary
Radiotherapy for prostate cancer treatment will be more effective when we have better knowledge of what patient anatomy needs to be targeted, and what needs to be avoided. This project will combine data collected during a large Australasian prostate cancer radiotherapy trial, ‘RADAR’, with data collected using new patient imaging methods to determine how patient anatomy impacts on the effectiveness of their treatment and the side-effects they experience.
Designing digital aquatic play to foster Australians’ engagement with water. From the beach to the pool, aquatic play is key to Australians’ quality of life and advances physical, mental and social wellbeing. This project harnesses our increasing use of interactive technology (such as wearables) to develop the world’s first design theory on interactive aquatic play. The project creates and evaluates three inspirational aquatic play prototypes, advancing confidence in water skills, self-expressio ....Designing digital aquatic play to foster Australians’ engagement with water. From the beach to the pool, aquatic play is key to Australians’ quality of life and advances physical, mental and social wellbeing. This project harnesses our increasing use of interactive technology (such as wearables) to develop the world’s first design theory on interactive aquatic play. The project creates and evaluates three inspirational aquatic play prototypes, advancing confidence in water skills, self-expression through movement and employment of safe practices to enrich Australian’s physical engagement with water. Digital media developers, government interventions and wellbeing groups can use the derived design knowledge to leverage digital technology and aquatic interactivity to foster Australians’ physical engagement with water.Read moreRead less
Antimalarial Drugs In Pregnancy: Preclinical And Clinical Studies Of Conventional And Novel Agents
Funder
National Health and Medical Research Council
Funding Amount
$470,115.00
Summary
Women in malaria-endemic areas such as coastal PNG are at high risk of malaria in pregnancy. To prevent the substantially increased malaria-associated morbidity and mortality in mother and child, and because even asymptomatic infections can be deleterious, there has been a move to giving antimalarial drugs regularly during pregnancy regardless of the mother's clinical or parasitological status. In poor tropical countries, such treatment usually comprises safe and inexpensive agents such as chlor ....Women in malaria-endemic areas such as coastal PNG are at high risk of malaria in pregnancy. To prevent the substantially increased malaria-associated morbidity and mortality in mother and child, and because even asymptomatic infections can be deleterious, there has been a move to giving antimalarial drugs regularly during pregnancy regardless of the mother's clinical or parasitological status. In poor tropical countries, such treatment usually comprises safe and inexpensive agents such as chloroquine and Fansidar. There are two main issues with this approach. First, the efficacy of such conventional agents is waning and this increases the risk of break-through malaria. Second, there are few data on how the drugs are handled in pregnancy on which to base recommendations for treatment. We plan to collect information on the disposition and effectiveness of chloroquine and Fansidar in women with malaria in pregnancy in PNG that should allow a critical appraisal of the usefulness of current regimens in PNG and in other tropical countries where parasite resistance to these agents is emerging. Artemisinin combination therapy (ACT) in the form of a novel artemisinin drug and a longer-acting partner has been suggested as the most promising alternative therapy for malaria in pregnancy if conventional drugs fail. We plan to assess the safety of a leading ACT formulation, namely dihydroartemisinin and the chloroquine-like drug piperaquine (DHA-PQ), in animals before extending our studies to women with malaria in PNG. These latter studies will allow an evaluation of the safety and efficacy of DHA-PQ as novel therapy for malaria in pregnancy in PNG and other tropical countries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100081
Funder
Australian Research Council
Funding Amount
$220,000.00
Summary
DomeLab: an ultra-high resolution experimental fulldome. DomeLab - an ultra-high resolution experimental fulldome: This project will establish the first ultra-high resolution (4000 x 4000 pixels) experimental fulldome in Australia (DomeLab). This fulldome facility will provide a powerful immersive dome-based video projection environment. Partners will work collaboratively across three themes: interactive media, future museology and experimental humanities. Through the national research services ....DomeLab: an ultra-high resolution experimental fulldome. DomeLab - an ultra-high resolution experimental fulldome: This project will establish the first ultra-high resolution (4000 x 4000 pixels) experimental fulldome in Australia (DomeLab). This fulldome facility will provide a powerful immersive dome-based video projection environment. Partners will work collaboratively across three themes: interactive media, future museology and experimental humanities. Through the national research services AARNet and Intersect's research data storage infrastructure, DomeLab will extend pioneering research in aesthetic frameworks and frontier technologies to benefit artistic, cultural, museological and humanities researchers. DomeLab is designed as a touring system and will be installed throughout the country at leading institutions. Read moreRead less
Transforming the early modern archive: the Emmerson Collection at SLV. In 2015, State Library Victoria (SLV) received the bequest of the Emmerson Collection: a national treasure of over 5000 early modern rare books and manuscripts, the first and only early modern archive of scale to be held by an Australian institution. Bringing together experts in early modern studies and the digital humanities with specialist library staff, this project will uncover the contents and scope of the collection and ....Transforming the early modern archive: the Emmerson Collection at SLV. In 2015, State Library Victoria (SLV) received the bequest of the Emmerson Collection: a national treasure of over 5000 early modern rare books and manuscripts, the first and only early modern archive of scale to be held by an Australian institution. Bringing together experts in early modern studies and the digital humanities with specialist library staff, this project will uncover the contents and scope of the collection and promote its international scholarly significance to the wider world. In doing so, it will develop new digital tools designed to unlock the value of this unique public resource for a wide range of end-users.Read moreRead less
When science meets art: an environmental portrait of the Shoalhaven River Valley. This project will involve a collaboration between art and science to create an environmental and cultural portrait of the Shoalhaven River Valley. Environmental readings of river and land quality will be converted into a visual and audio display for both on-site and off-site visitors.
Unravelling The Mechanism Of MHC Class-I Associated Drug Hypersensitivities
Funder
National Health and Medical Research Council
Funding Amount
$566,308.00
Summary
Some drugs cause adverse reactions that are life threatening. We think these reactions are mediated by killer T cells as they are genetically controlled by immune response genes that normally guide immunity to microbes. We will study immune reactions to the drug abacavir, used to treat HIV (AIDS); allopurinol used to prevent gout and carbamazepine, used to treat epilepsy. The study may also help devise better treatments for patients who experience severe forms of these reactions.
Amplifying Voices from the Royal Commission into Aged Care. The Royal Commission into Aged Care Quality and Safety is a singular opportunity to reform Australian aged care and redress the marginalisation of aged care residents—a vulnerable demographic whose voices too often go unheard. Using innovative arts-based forms of storytelling, this project explores how non-traditional approaches can provide older Australians with more visibility in aged care policy debates. Combining media analysis with ....Amplifying Voices from the Royal Commission into Aged Care. The Royal Commission into Aged Care Quality and Safety is a singular opportunity to reform Australian aged care and redress the marginalisation of aged care residents—a vulnerable demographic whose voices too often go unheard. Using innovative arts-based forms of storytelling, this project explores how non-traditional approaches can provide older Australians with more visibility in aged care policy debates. Combining media analysis with poetic inquiry, participatory photography, citizen storytelling, and interactive art, this project amplifies the voices of residents and engages policy makers, providers, and the public in a reflexive, inclusive conversation about the past, present and future of aged care. Read moreRead less
Narrative reformulation of museological data: the coherent representation of information by users in interactive systems. The proposed research seeks to provide Australia with a long-term opportunity to enhance its involvement in the billion-dollar creative economy by building the world’s first immersive 360-degree interactive data browser. Research into such systems benefits society by providing a cutting-edge development in digital technology and information access that enables a creative inno ....Narrative reformulation of museological data: the coherent representation of information by users in interactive systems. The proposed research seeks to provide Australia with a long-term opportunity to enhance its involvement in the billion-dollar creative economy by building the world’s first immersive 360-degree interactive data browser. Research into such systems benefits society by providing a cutting-edge development in digital technology and information access that enables a creative innovation culture. Through applied research into the narrative forms that underpin museological archives, this study will ensure that Australia remains at the forefront of the growing world-wide research into interactive technology thereby assisting the global digital media industry to tackle emergent challenges. Read moreRead less
A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.