Preclinical Evaluation Of The Novel Therapeutic Compound APP96-110 In An Ovine Model Of Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$874,734.00
Summary
Traumatic brain injury (TBI) is a significant cause of death and disability, and yet there are currently no effective treatments to improve outcome following such an insult. Our laboratory has developed a novel therapeutic compound, by identifying an endogenous neuroprotective molecule, in the amyloid precursor protein and then identifying the active site and modifying it to improve its efficacy. We will be testing this compound in our sheep model of TBI.
An Examination Of The Relationship Between Alcohol-related Injury (ARI) And Licensed Premises
Funder
National Health and Medical Research Council
Funding Amount
$78,686.00
Summary
There is growing interest in acute alcohol-related problems, and especially injuries. These are often experienced by young people, frequently as a consequence of intoxication or drinking in unsafe settings. Little work has been undertaken in Australia to systematically examined alcohol-related injuries (ARIs). This study will examine ARIs, identify the frequency with which such problems present to a local hospital, record the nature of the injuries, details of the person sustaining it, and the d ....There is growing interest in acute alcohol-related problems, and especially injuries. These are often experienced by young people, frequently as a consequence of intoxication or drinking in unsafe settings. Little work has been undertaken in Australia to systematically examined alcohol-related injuries (ARIs). This study will examine ARIs, identify the frequency with which such problems present to a local hospital, record the nature of the injuries, details of the person sustaining it, and the drinking location. Characteristics of drinking locations and drinking settings, in particular licensed premises, will be examined to determine their association with ARIs. Then an intervention will be undertaken in conjunction with local police, to address the conditions of the drinking environment with the aim of reducing ARIs and other alcohol-related problems stemming from licensed premises. The intervention will form part of a randomised controlled trial where licensed premises, identified through monthly police data as hot spots, receive either an intervention or act as a control. In the following month, controls receive the intervention (a cross-over design). The intervention was established in 1998 by Gold Coast police and involves police, fire and liquor licensing officers undertaking an on-site inspection and taking prescribed actions. It is hypothesised that this action should result in a decreased level of ARIs being generated from premises which receive the intervention, compared to those that do not. This is an intersectoral, collaborative project aimed at improving community safety through a concerted effort by police, health and the licensees.Read moreRead less
Addressing significant product safety knowledge gaps for older Australians . This project addresses significant gaps in contemporary knowledge of consumer product safety risks for older persons, with 25 years since the last Australian product safety research found older persons are at high risk of product-related injury/death. Products have evolved substantially and aged care models have changed in that time. This project generates contemporary knowledge of unsafe products causing injuries/death ....Addressing significant product safety knowledge gaps for older Australians . This project addresses significant gaps in contemporary knowledge of consumer product safety risks for older persons, with 25 years since the last Australian product safety research found older persons are at high risk of product-related injury/death. Products have evolved substantially and aged care models have changed in that time. This project generates contemporary knowledge of unsafe products causing injuries/deaths, risk factors/behaviours, and human rights issues. Outcomes benefiting the Australian community are improved prediction/characterisation of product safety issues for older Australians informing safer product design and use, targetted regulatory responses, ageing-in-place strategies, and creating safer home environments.Read moreRead less
Understanding The Risk Factors And Burden Of Heart Disease And Stroke For Aboriginal And Torres Strait Islander Women
Funder
National Health and Medical Research Council
Funding Amount
$86,117.00
Summary
Heart disease and stroke is the leading cause of death for Aboriginal and Torres Strait Islander people, and accounts for over one quarter in the life expectancy gap. A recent survey found that 59% of Aboriginal and Torres Strait Islander women live with heart disease or stroke. This PhD seeks to understand the risks of, and hospitalisation and mortality from heart disease and stroke in Aboriginal and Torres Strait Islander women. The project is guided by a women’s Advisory Group.
Elucidating the mechanics of facet dislocation and fracture in the neck. This project aims to address shortcomings in understanding the mechanics of neck trauma. Understanding the mechanical factors leading to cervical facet dislocation and fracture is necessary to improve injury prevention strategies and their assessment. This project expects to generate new knowledge in the area of spinal injury biomechanics, developing and using new experimental techniques. The project expects to provide know ....Elucidating the mechanics of facet dislocation and fracture in the neck. This project aims to address shortcomings in understanding the mechanics of neck trauma. Understanding the mechanical factors leading to cervical facet dislocation and fracture is necessary to improve injury prevention strategies and their assessment. This project expects to generate new knowledge in the area of spinal injury biomechanics, developing and using new experimental techniques. The project expects to provide knowledge necessary to improve crash test dummy design, associated injury criteria, and computational models, which provide the potential for improved injury prevention measures and methods for assessing existing and new technologies. The anticipated benefits of this project will be significant in reducing the personal and economic burden of spinal injuries.Read moreRead less
Special Research Initiatives - Grant ID: SR0566924
Funder
Australian Research Council
Funding Amount
$52,825.00
Summary
Develop and pilot an e-cohort research technique for longitudinal studies using multiple international cohorts. The aim of this project is to develop and pilot an e-cohort research methodology suitable for longitudinal studies with multiple international cohorts. Historically, studies of this nature are expensive as they are conducted in traditional paper-based mode and the studies are therefore confined to one country. Population-based epidemiological studies of this type have led to major scie ....Develop and pilot an e-cohort research technique for longitudinal studies using multiple international cohorts. The aim of this project is to develop and pilot an e-cohort research methodology suitable for longitudinal studies with multiple international cohorts. Historically, studies of this nature are expensive as they are conducted in traditional paper-based mode and the studies are therefore confined to one country. Population-based epidemiological studies of this type have led to major scientific advances in global health for the last sixty years. Developing and employing e-research techniques in longitudinal studies will significantly reduce the costs of this important research and enable multi-national cohorts of participants that will result in high quality research.Read moreRead less
Health Impacts Of Sleep Apnea In Australian Men- A Longitudinal Population Study.
Funder
National Health and Medical Research Council
Funding Amount
$312,056.00
Summary
Obstructive sleep apnea (OSA) is very common, seen in 60-70% of men over 40 years old. OSA is linked to a number of serious conditions, e.g. heart disease and diabetes. However, we don't know which men are at risk of long term complications from OSA. Our aim is to follow-up men from a community sample of 1000 men who had sleep studies in 2010 to help identify who is at risk of poor health from OSA.
Understanding and preventing gun violence: A qualitative study. Gun violence causes significant harm across Australian communities. Excluding sexual assault, firearms feature in nearly one in 10 violent crimes. The annual costs of gun violence run into tens of millions of dollars. This project aims to make an original qualitative contribution to understanding and preventing gun violence in three contexts: drug dealing/trafficking, other organised crime activity, and armed robbery. The proposed r ....Understanding and preventing gun violence: A qualitative study. Gun violence causes significant harm across Australian communities. Excluding sexual assault, firearms feature in nearly one in 10 violent crimes. The annual costs of gun violence run into tens of millions of dollars. This project aims to make an original qualitative contribution to understanding and preventing gun violence in three contexts: drug dealing/trafficking, other organised crime activity, and armed robbery. The proposed research would be the first study nationally - and one of the very few internationally - to interview convicted gun crime users about the acquisition and use of firearms in criminal life. Project results are expected to have direct implications for reducing the impact of gun violence in Australia.Read moreRead less
Linking Place To Metabolic Syndrome Via Behavioural And Psychological Antecedents: Levers For Public Health Intervention
Funder
National Health and Medical Research Council
Funding Amount
$295,135.00
Summary
This collaboration involves the SA Health Department and community partners in analyses of local data from a 10-year biomedical cohort to (i) identify features of residential areas that are related to the metabolic syndrome and (ii) assess the mechanism by which area features influence metabolic syndrome through effects on behavioural and psychosocial mediators. The knowledge generated will inform policy intervention via urban planning and public health actions to support healthful lifestyles.
Mathematical models for water management systems. The Australian community is currently talking about schemes to return water to the Murray-Darling river system to combat increased salinity and dramatically reduced river flow. Many believe that vastly improved water management policies are essential to maintain agricultural well-being in Australia. Salinity and water quality depend directly on flow rates and are also important in smaller catchments. In this study we will use statistical rainf ....Mathematical models for water management systems. The Australian community is currently talking about schemes to return water to the Murray-Darling river system to combat increased salinity and dramatically reduced river flow. Many believe that vastly improved water management policies are essential to maintain agricultural well-being in Australia. Salinity and water quality depend directly on flow rates and are also important in smaller catchments. In this study we will use statistical rainfall models and stochastic dynamic programming to find practical water management policies that minimise the risk to water supply. We will develop an interactive simulation and management tool using a modern computer graphics package.Read moreRead less