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Using Drosophila to analyse a master regulator of epithelial homeostasis. Aims:
This proposal aims to use genetic and cell biological analysis of the vinegar fly, Drosophila, to identify the function of the grainyhead gene in intestinal regeneration.
Significance:
This gene is conserved in all animal species and appears to be a master regulator of epithelial tissue development but it is unclear how it can both influence stem cell maintenance and production of functional cell types.
Expected out ....Using Drosophila to analyse a master regulator of epithelial homeostasis. Aims:
This proposal aims to use genetic and cell biological analysis of the vinegar fly, Drosophila, to identify the function of the grainyhead gene in intestinal regeneration.
Significance:
This gene is conserved in all animal species and appears to be a master regulator of epithelial tissue development but it is unclear how it can both influence stem cell maintenance and production of functional cell types.
Expected outcomes:
We will identify a new mechanism that governs tissue development, and introduce new imaging and genetic technologies to the Australian research community.
Benefit:
We expect potential economic and commercial interest in development of new gene analysis tools and biotechnological tissue manipulation applications.Read moreRead less
About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock a ....About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock and its role in the normal biology of the heart. New data will significantly enhance our understanding of the biology of MR and cortisol for the circadian time keeping function in peripheral tissues, and gain a clearer understand how our heart cells adapt to environmental circadian disruptors such as shift work. Read moreRead less
Biomolecular condensates in mRNA-regulation in germ cells. This project aims to investigate how cells form microenvironments that are enriched for specific biological functions. Using a powerful combination of cutting-edge in vitro and in vivo experiments, the project will generate new knowledge in the emerging area of liquid-liquid phase separation. We will analyse the formation of germ granules that are required for fertility. The expected outcome is a transformational understanding of how liq ....Biomolecular condensates in mRNA-regulation in germ cells. This project aims to investigate how cells form microenvironments that are enriched for specific biological functions. Using a powerful combination of cutting-edge in vitro and in vivo experiments, the project will generate new knowledge in the emerging area of liquid-liquid phase separation. We will analyse the formation of germ granules that are required for fertility. The expected outcome is a transformational understanding of how liquid-liquid phase separation occurs in cells which, in the longer term, will have applications in biotechnology and disease treatment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101568
Funder
Australian Research Council
Funding Amount
$349,127.00
Summary
Maximising impacts of aid for health by incorporating local priorities. This project aims to increase effectiveness of Australia’s health aid program in the Asia-Pacific region by employing advanced health economics methods and working with stellar international collaborators. Australia has committed to better align health aid with recipient priorities, however, there is a need for evidence on how best to achieve this. This project expects to generate new knowledge about the benefits from increa ....Maximising impacts of aid for health by incorporating local priorities. This project aims to increase effectiveness of Australia’s health aid program in the Asia-Pacific region by employing advanced health economics methods and working with stellar international collaborators. Australia has committed to better align health aid with recipient priorities, however, there is a need for evidence on how best to achieve this. This project expects to generate new knowledge about the benefits from increased alignment. Expected outcomes include increased regional research capacity and strategies for stakeholders to increase alignment for greater impact. This should benefit Australia’s health aid program, so that it meets the expectations of the Australian public and improves the health and wellbeing of aid beneficiaries.Read moreRead less
Applications-oriented elucidation of germination triggers for Emu Bush seed. The project aims to determine the environmental and genetic mechanisms that currently limit seed germination in Emu Bush (Eremophila) species. The anticipated project outcomes aim to develop new technologies for efficient and mass production of Emu Bush seedlings. The outcomes will improve land restoration by increasing plant diversity and reducing establishment costs, and will also provide the nursery industry with nov ....Applications-oriented elucidation of germination triggers for Emu Bush seed. The project aims to determine the environmental and genetic mechanisms that currently limit seed germination in Emu Bush (Eremophila) species. The anticipated project outcomes aim to develop new technologies for efficient and mass production of Emu Bush seedlings. The outcomes will improve land restoration by increasing plant diversity and reducing establishment costs, and will also provide the nursery industry with novel products for home gardens. The intended project benefits are to increase the diversity of Australian native plants used for restoration and ornamental purposes and to promote the conservation of species in this plant family and its genetic diversity.Read moreRead less
Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It w ....Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It will bring the armoury of policy analysis instruments available to these countries up to the standard now enjoyed by the developed world. Indonesia, on the brink of major pension reform, will be used as a test bed. Data sets will be developed to allow the model structure to be applied to other emerging economies in Asia. Read moreRead less
How age & sex impact the transcriptional control of mammalian muscle growth. Maintaining healthy muscle is crucial throughout all stages of life. Aging is associated with the loss of muscle and older muscles are resistant to growth due to age-related changes in gene expression and responsiveness. Many genes are expressed differently in male versus female muscle, which may have implications for sex-differences in muscle growth and aging. This project will generate new knowledge on which genes and ....How age & sex impact the transcriptional control of mammalian muscle growth. Maintaining healthy muscle is crucial throughout all stages of life. Aging is associated with the loss of muscle and older muscles are resistant to growth due to age-related changes in gene expression and responsiveness. Many genes are expressed differently in male versus female muscle, which may have implications for sex-differences in muscle growth and aging. This project will generate new knowledge on which genes and biological pathways are crucial in determining mammalian muscle size and growth across the lifespan and between the sexes. Application of this knowledge may lead to future approaches to enable a healthy start to life and promote healthy aging in Australians and have implications for agriculture and muscle as a food source.Read moreRead less
Bioinspired Ion Transporters for Efficient Energy Conversion and Storage. This project aims to fabricate bioinspired light-driven ion transporters with biological-level active ion transport efficiency for efficient energy conversion and storage. Engineering of artificial membranes with ion-pump-like pore structures, specific ion binding sites and photo-excited molecular gates by an innovative bioinspired approach is expected to generate new knowledge in the field of biomimetic design of artifici ....Bioinspired Ion Transporters for Efficient Energy Conversion and Storage. This project aims to fabricate bioinspired light-driven ion transporters with biological-level active ion transport efficiency for efficient energy conversion and storage. Engineering of artificial membranes with ion-pump-like pore structures, specific ion binding sites and photo-excited molecular gates by an innovative bioinspired approach is expected to generate new knowledge in the field of biomimetic design of artificial ion-transporter membranes and bring new technologies to applications such as in solar energy harvesting, osmotic power generation, ionic batteries, and ionic circuits. The proposed research should provide significant benefits such as new energy conversion and storage technologies for Australian manufacturing industry.Read moreRead less
Porous transparent conducting oxides for efficient solar fuel production. This project aims to develop highly porous, transparent and electrically conducting networks of oxide nanoparticles for artificial photosynthesis applications. The majority of hydrogen is currently produced via natural gas reforming, a process that generates a significant carbon footprint due to the use of fossil fuels. This project will develop novel materials and fabrication methods to improve the efficiency of hydrogen ....Porous transparent conducting oxides for efficient solar fuel production. This project aims to develop highly porous, transparent and electrically conducting networks of oxide nanoparticles for artificial photosynthesis applications. The majority of hydrogen is currently produced via natural gas reforming, a process that generates a significant carbon footprint due to the use of fossil fuels. This project will develop novel materials and fabrication methods to improve the efficiency of hydrogen production using clean and renewable solar energy. This project will contribute to development of technologies for the chemical storage of renewable energy, and reduction of carbon dioxide emissions. This will have applications in the areas of optoelectronic devices, medical biosensors, and photocatalysis, offering downstream benefits for the society, the economy and the environment.Read moreRead less