Brain sodium channel: functional role of developmentally regulated alternative splicing. This project will identify the roles of neonatal and adult forms of a sodium channel in the function of neurons in the developing brain. Sodium channels are vital for brain function and this study will improve our understanding of the function of healthy brain as well as of underlying mechanisms of some neurological disorders.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668246
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Advanced Cell Labelling and Imaging Facility. Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and ageing-related conditions. The proposed facility will allow researchers to test in vivo g ....Advanced Cell Labelling and Imaging Facility. Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and ageing-related conditions. The proposed facility will allow researchers to test in vivo gene/pharmaceutical therapies as well as to better understand the genetic regulation of normal cellular processes. Read moreRead less
Neourobiology Of Human Epilepsy: Genes, Cellular Mechanisms,network And Whole Brain
Funder
National Health and Medical Research Council
Funding Amount
$17,652,824.00
Summary
The team is comprised of neurologists, molecular geneticists, physiologists and brain imaging specialists and leads the world in the discovery of the genetic causes of epilepsy. They will continue to identify genes underlying epilepsy and study how genetic variations result in development of seizures. Advanced brain imaging will be used to understand the effects of genetic variation on brain structure and function. This study may lead to new diagnostic methods and treatments for epilepsy.
Central pathways regulating visceral pain. This project aims to investigate the neural pathways within the spinal cord and brain processing colorectal pain perception. The project aims to identify the spinal cord neurons relaying colorectal signalling into the brain and the influence of descending modulation from the brainstem upon these pathways. The outcomes will greatly benefit fundamental understanding of the central pathways processing visceral pain.
Discovery Early Career Researcher Award - Grant ID: DE130100323
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The regulation by transcription factor phosphorylation upon the myelinating process. The project will investigate the novel molecular events that control the myelinating process, which is essential for normal nervous system function. Outcomes of this project may aid the development of novel interventions to improve control of demyelinating diseases, which represent a substantial socio-economic burden.
Relationship of the functional architecture of the mammalian brain to its microcircuitry. The project seeks to understand a very fundamental issue in neuroscience: how the connectivity and architecture of the cortex are related to the functions of neurones in that area? This will be investigated by imaging the surface of the visual cortex of anaesthetised cats and monkeys as special visual patterns are shown to the eye/s. The overall picture gained of the active and inactive cortical areas will ....Relationship of the functional architecture of the mammalian brain to its microcircuitry. The project seeks to understand a very fundamental issue in neuroscience: how the connectivity and architecture of the cortex are related to the functions of neurones in that area? This will be investigated by imaging the surface of the visual cortex of anaesthetised cats and monkeys as special visual patterns are shown to the eye/s. The overall picture gained of the active and inactive cortical areas will be related to the properties of neurones in those areas and to those of individual input and output fibres. An optical imaging equipment will be acquired in 2004 using a recently awarded LIEF grant to the CI.Read moreRead less
Thalamic inputs and cortical microcircuitry underlying the functional architecture of the visual cortex. This project seeks to reveal the fundamental circuitry of the visual cortex that enables visual perception. Such understanding is essential not only for explaining many perceptual disturbances, but also for providing a neuronal basis for developing functionally useful prostheses for the blind.
Synaptic and network properties underlying neural coding in the mammalian visual cortex. This study will:
(1) Increase our basic understanding of visual function that can help to explain many clinical perceptual disturbances. (2) Help in providing a detailed picture of intracortical neuronal networks that can form the basis for a prosthesis for the blind. (3) Discover the principles of neural organization underlying functions such as figure-ground segregation and perceptual learning which can i ....Synaptic and network properties underlying neural coding in the mammalian visual cortex. This study will:
(1) Increase our basic understanding of visual function that can help to explain many clinical perceptual disturbances. (2) Help in providing a detailed picture of intracortical neuronal networks that can form the basis for a prosthesis for the blind. (3) Discover the principles of neural organization underlying functions such as figure-ground segregation and perceptual learning which can inspire practical algorithms for robotic vision. (4) Train graduate students and postdoctoral fellows in state of the art techniques in a stimulating intellectual environment.Read moreRead less
Thalamo-cortical organisation in visual information processing. This study will: (1) Increase our basic understanding of visual function that can help to explain many clinical perceptual disturbances. (2) Help in providing a detailed picture of intracortical neuronal networks that can form the basis for a prosthesis for the blind. (3) Discover the principles of neural organization underlying functions such as figure-ground segregation and perceptual learning which can inspire practical algorithm ....Thalamo-cortical organisation in visual information processing. This study will: (1) Increase our basic understanding of visual function that can help to explain many clinical perceptual disturbances. (2) Help in providing a detailed picture of intracortical neuronal networks that can form the basis for a prosthesis for the blind. (3) Discover the principles of neural organization underlying functions such as figure-ground segregation and perceptual learning which can inspire practical algorithms for robotic vision. (4) Train graduate students and postdoctoral fellows in state of the art techniques in a stimulating intellectual environmentRead moreRead less
Gene-environment interactions mediating experience-dependent plasticity in the healthy and diseased brain. The aim of this project is to understand how genes and environment combine to affect susceptibility to various brain disorders, using models of human diseases and manipulating environmental factors such as mental and physical activity. The project's focus is on neurological and psychiatric disorders, including Huntington's disease, depression, schizophrenia and autism.