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The Role Of BMP Signalling During Chronic Demyelination And Myelin Repair
Funder
National Health and Medical Research Council
Funding Amount
$67,381.00
Summary
Multiple sclerosis (MS) is the most common neurodegenerative disease affecting young adults. It is a disease that kills myelin cells, which are important support cells for neurons and critical for neuronal function. This research investigates the role of a specific signaling pathway with respect to myelin cell production and repair with the ultimate aim of identifying regenerative therapeutics for MS.
The Biology Of Staphylococcus Epidermidis Biofilm Formation On Silicone Implantable Medical Devices And The Role Of Implant Surface Antibiotic Technology In The Prevention Of Bacterial Biofilm In And Animal Model
Funder
National Health and Medical Research Council
Funding Amount
$113,322.00
Summary
Hospital acquired infections continue to rise with over 60% occuring in patients with medical implants. Infections are due to skin bacteria forming a microscopic slime, or biofilm, around the implant. Biofilm infection is only diagnosed after implant removal, responds poorly to antibiotics, and can cause implant failure, such as joint loosening & bone infection in joint replacements and breast deformity with silicone implants. This project uses an animal model to evaluate different surface treat ....Hospital acquired infections continue to rise with over 60% occuring in patients with medical implants. Infections are due to skin bacteria forming a microscopic slime, or biofilm, around the implant. Biofilm infection is only diagnosed after implant removal, responds poorly to antibiotics, and can cause implant failure, such as joint loosening & bone infection in joint replacements and breast deformity with silicone implants. This project uses an animal model to evaluate different surface treatments to prevent bacterial biofilm formation.Read moreRead less
Assessment Of The Mechanisms Involved And Severity Of Arterial Disease In Insulin Resistant States
Funder
National Health and Medical Research Council
Funding Amount
$64,631.00
Summary
Type 2 Diabetes is a major risk factor towards atherosclerosis or blood vessel narrowing. This can lead to vascular complications such as heart attacks, strokes and amputations. This research aim to examine the relationship between some of the mechanisms and their contribution towards vascular disease in the progression from normal health, through insulin resistance to diabetes. This understanding will provide diagnostic tools and treatment targets for diabetic vascular disease.
Investigating The Mechanisms Underpinning The Dynamic Vessel Response In People With Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$18,808.00
Summary
Endothelial dysfunction has been well-hypothesised as one of the key players in the pathogenesis of DR. However, there is strong evidence suggesting a neurovascular coupling mechanism in the retinal circulation during flicker. It is therefore unclear whether reduced flicker light induced vasodilation observed in diabetes and DR is associated with endothelial dysfunction, an impairment of neurovascular coupling or both. This project aims to address this important knowledge gap.