Parametric Brain Imaging via Modeling and Analysis of Electroencephalographic Signals. Parameters of brain function and physiology will be spatially imaged with high time resolution via their effects on electroencephalographic (EEG) signals, a form of imaging that is impossible with existing methods. This will be achieved by improving existing physiologically-based models of the generation of EEGs and developing analysis tools based on fitting of model predictions to multielectrode EEG data. T ....Parametric Brain Imaging via Modeling and Analysis of Electroencephalographic Signals. Parameters of brain function and physiology will be spatially imaged with high time resolution via their effects on electroencephalographic (EEG) signals, a form of imaging that is impossible with existing methods. This will be achieved by improving existing physiologically-based models of the generation of EEGs and developing analysis tools based on fitting of model predictions to multielectrode EEG data. The results will be used to probe spatiotemporal features of EEGs in normal subjects to explore the underlying fundamental mechanisms and to infer novel parameter variations of practical relevance.Read moreRead less
Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to ....Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to use innovative technology with expected high economic potential, and benefit small biotech companies by facilitating pre-clinical and clinical development of new pharmaceuticals. The new motion tracking and image reconstruction technologies developed will strengthen Australia's leading position in engineering and biomedical systems development.Read moreRead less
An Automated Bioimaging System for High-Content Cell-Cycle Screening. 1) Providing a better understanding of the biological complexities
that will advance knowledge in life science research and facilitate the development of new anti-cancer drugs.
2) Supporting Australian academic institutions in a challenging field of innovative research through international, interdisciplinary collaborations, and publications in journals of high quality scientific research.
3) Providing research training ....An Automated Bioimaging System for High-Content Cell-Cycle Screening. 1) Providing a better understanding of the biological complexities
that will advance knowledge in life science research and facilitate the development of new anti-cancer drugs.
2) Supporting Australian academic institutions in a challenging field of innovative research through international, interdisciplinary collaborations, and publications in journals of high quality scientific research.
3) Providing research training in a research venture that requires expertise and collaboration in the disciplines of biology, engineering, computer science, and mathematics.
4) Bringing economic and social benefits for Australia by enhancing important industries and existing technologies in medicine, and biotechnology.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882682
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
The Australasian Pollen and Spore Atlas. The results generated in this project will enhance Australian research capabilities across multiple disciplines by providing access to key knowledge of pollen and spores in our region. A unified approach to the archiving, presentation and accessibility to existing and evolving databases will provide a considerably improved context for identification and knowledge pooling of any given pollen or spore type. This will create a nexus for novel interactions be ....The Australasian Pollen and Spore Atlas. The results generated in this project will enhance Australian research capabilities across multiple disciplines by providing access to key knowledge of pollen and spores in our region. A unified approach to the archiving, presentation and accessibility to existing and evolving databases will provide a considerably improved context for identification and knowledge pooling of any given pollen or spore type. This will create a nexus for novel interactions between researchers and end users of these data from within and beyond Australia's borders.Read moreRead less
What is the spatial and environmental distribution of phylogenetic diversity in the Australian biota? Almost nothing is known about the geographic distribution of phylogenetic relationships across Australia at fine resolutions of the order of tens of kilometres. The aim of this research is to map the spatial patterns of phylogenetic diversity in the Australian biota and identify possible environmental controls over them. We will analyse five disparate groups at a spatial resolution that is ord ....What is the spatial and environmental distribution of phylogenetic diversity in the Australian biota? Almost nothing is known about the geographic distribution of phylogenetic relationships across Australia at fine resolutions of the order of tens of kilometres. The aim of this research is to map the spatial patterns of phylogenetic diversity in the Australian biota and identify possible environmental controls over them. We will analyse five disparate groups at a spatial resolution that is orders of magnitude finer than previous research, analysing their relationship with possible environmental controls using advanced spatial analysis methods. The knowledge we will generate about the spatial distribution of these relationships is essential to understand and conserve Australia's unique biodiversity.Read moreRead less
Nonlinear Dynamics of Pulse Coupled Oscillators. A mathematical model of the heart pacemaker system will be created, based on simple interacting units. These units have been shown to be good models of physiological information e.g. the discrimination of different influences on heart rate. We will firstly look at the interaction of the units in simple combinations and then tune the model to mimic the behaviour of the cardiac pacemaker.
Potential benefits may arise from elucidating the mechanis ....Nonlinear Dynamics of Pulse Coupled Oscillators. A mathematical model of the heart pacemaker system will be created, based on simple interacting units. These units have been shown to be good models of physiological information e.g. the discrimination of different influences on heart rate. We will firstly look at the interaction of the units in simple combinations and then tune the model to mimic the behaviour of the cardiac pacemaker.
Potential benefits may arise from elucidating the mechanisms underlying arrhythmias which contribute to ?sudden cardiac death? in young men, and suggesting strategies for artificial pacemakers to effectively arrest abnormal rhythms before they convert to potentially fatal fibrillation.Read moreRead less
Quantifying the Tree of Life's Diversity with the Paleobiology Database. The Paleobiology Database is the Internet's key source of scientific data on the fossil record. It records names and classification of fossil organisms and the ages, locations, and environments of the places that yield these fossils. It has often been used to estimate the number of species existing at different points in geological time. Macquarie will house the Database as it is expanded to record evolutionary relations ....Quantifying the Tree of Life's Diversity with the Paleobiology Database. The Paleobiology Database is the Internet's key source of scientific data on the fossil record. It records names and classification of fossil organisms and the ages, locations, and environments of the places that yield these fossils. It has often been used to estimate the number of species existing at different points in geological time. Macquarie will house the Database as it is expanded to record evolutionary relationships of many species. This information will help to estimate dates of origination for major groups such as mammals and birds. It will also help to show whether mass extinctions tend to target old groups with few surviving species, which will help to predict which groups will survive the current mass extinction.Read moreRead less
Topological Approaches for Three Dimensional Graph Drawing. Human analysis of huge quantities of relational data in biotechnology, web engineering, social networks, and computer networks requires visualization. In recent years, three-dimensional visualisation has promised to give new insights into such abstract data. However the past ten years of visualization research has had very little impact on the industry; visualization software providers have not adopted visualization methods developed b ....Topological Approaches for Three Dimensional Graph Drawing. Human analysis of huge quantities of relational data in biotechnology, web engineering, social networks, and computer networks requires visualization. In recent years, three-dimensional visualisation has promised to give new insights into such abstract data. However the past ten years of visualization research has had very little impact on the industry; visualization software providers have not adopted visualization methods developed by academics. We hypothesise that current 3D relational visualization methods fail because they do not pay attention to the human perception of topology. In this project we will leverage mathematical topology to construct new methods for the 3D visualization of relational data.
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New Methods for Interactive Visualization of Large Microarray Data Sets. This project will investigate methods for visualising graphs produced by AI-based analysis of real-world biological data. These new visualisation methods will assist biologists to develop new DNA Microarray experiments, the source of raw data for visualisation. Data from new enhanced experiments, plus background knowledge from integrated public databases will produce richer data for visualisation, thus creating a positive f ....New Methods for Interactive Visualization of Large Microarray Data Sets. This project will investigate methods for visualising graphs produced by AI-based analysis of real-world biological data. These new visualisation methods will assist biologists to develop new DNA Microarray experiments, the source of raw data for visualisation. Data from new enhanced experiments, plus background knowledge from integrated public databases will produce richer data for visualisation, thus creating a positive feedback loop in the course of research into both topics.Read moreRead less
ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand add ....ARC Centre for Complex Systems. The Australian Centre for Complex Systems brings together leading researchers from several disciplines and institutions to conduct research on questions fundamental to understanding and managing complex systems. Its core research program, based on the theme of computation in and by networks of agents, has two interwoven strands. The science strand addresses questions about emergent properties, natural computation, and nonlinear dynamics. The engineering strand addresses issues about methodology, modelling toolkits, and management and control. Practical applications are advanced via collaborative projects that address key issues in biology, environment, and socio-economics.Read moreRead less