Identification And Chracterization Of Host Cell Receptors For Influenza A Viruses
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
Following inhalation, influenza virus infects cells of the immune system and epithelial cells lining the airways. Currently, it is not clear how influenza virus attaches to and infects these cells. This project will use new ways to identify receptors for influenza virus on human epithelial cells and immune cells. The ultimate identification of these receptors would have important implications for the development of new drugs to treat influenza virus infections.
Severe Influenza: Epidemiology, Clinical Aspects & Public Health Responses
Funder
National Health and Medical Research Council
Funding Amount
$120,659.00
Summary
The 2009 flu pandemic exposed gaps in Australia's surveillance & public health policies. Using a hospital surveillance system (FluCAN) set up after the emergence of the pandemic virus, I will assess epidemiological, clinical & public health aspects of influenza to answer questions such as: what is the effectiveness of the influenza immunisation program? What is the burden of disease of severe influenza? Which forms of surveillance are best for different settings in Australia & in Asia-Pacific?
Understanding Influenza-specific T Cell Immunity In The Indigenous And Non-Indigenous Populations
Funder
National Health and Medical Research Council
Funding Amount
$49,202.00
Summary
Hospitalisation and mortality rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. To identify potential vaccine targets we firstly have to determine which viral proteins will induce a large protective immune response. These responses vary between ethnicities thus comparisons will be drawn between Indigenous and non-Indigenous Australians to determine multiple vaccine candidates tha ....Hospitalisation and mortality rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. To identify potential vaccine targets we firstly have to determine which viral proteins will induce a large protective immune response. These responses vary between ethnicities thus comparisons will be drawn between Indigenous and non-Indigenous Australians to determine multiple vaccine candidates that will be protective across ethnicities.Read moreRead less