Limiting Tuberculosis Transmission And Improving The Care Of Affected Children
Funder
National Health and Medical Research Council
Funding Amount
$412,419.00
Summary
Tuberculosis (TB) is the biggest infectious disease killer on the planet. Drug-resistant TB poses a particular challenge in the Asia-Pacific region. My research will assist Australia to progress towards domestic TB elimination. It will improve the management of “difficult to treat” cases and help to safeguard the public against ongoing TB transmission. Work in neighbouring countries will help to contain the spread of drug-resistant TB and protect vulnerable young children.
Improving Prevention, Tracking And Treatment Of Major Human Bacterial Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$467,961.00
Summary
This research fellowship will lead to a detailed understanding of the mechanisms by which bacteria become resistant to antibiotics and cause diseases, how bacterial pathogens evolve and spread in the Australian community, and will result in new understanding of the optimal treatment of bacterial diseases and identification of compounds for new antibiotic development.
Translational Research On Malignant Pleural Effusion And Pleural Infection
Funder
National Health and Medical Research Council
Funding Amount
$487,891.00
Summary
I am a leading researcher in pleural effusions (fluid build-up in the chest) from cancer and infection. I run a multicentre clinical trial team to answer important questions directly relevant to patient care, as well as a lab research group with proven record of discovery new treatment targets. This fellowship will capitalize on platforms I have built and determine best approach to remove effusions, understand etiologic roles of the fluid ultimately to find ways to stop fluid from forming.
Determinants Of The Outcomes From Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$585,269.00
Summary
This Fellowship will allow Professor Lloyd to continue clinical and laboratory research in two areas: firstly, in relation to prevention of transmission of hepatitis C infection, and scale up of antiviral treatments, particularly amongst prisoners. Secondly, in studies investigating the biological basis of chronic fatigue states following acute infection or cancer treatment, and also in development of effective treatment for chronic fatigue states.
Redefining Antibiotic Dosing To Reduce Bacterial Resistance
Funder
National Health and Medical Research Council
Funding Amount
$474,513.00
Summary
>3000 Australians die every year from severe infections (nearly 3-fold higher in number than our annual road toll). These treatment failures are due to sub-optimal antibiotic dosing from a poor understanding of why concentrations are different in these patients. I will use my laboratory to define what antibiotic concentrations we need to achieve and perform clinical studies with my collaborative network to demonstrate that we can redefine antibiotic dosing to reduce the emergence of superbugs ....>3000 Australians die every year from severe infections (nearly 3-fold higher in number than our annual road toll). These treatment failures are due to sub-optimal antibiotic dosing from a poor understanding of why concentrations are different in these patients. I will use my laboratory to define what antibiotic concentrations we need to achieve and perform clinical studies with my collaborative network to demonstrate that we can redefine antibiotic dosing to reduce the emergence of superbugs.Read moreRead less
Improving Health Outcomes For Disadvantaged Children
Funder
National Health and Medical Research Council
Funding Amount
$585,269.00
Summary
I am a paediatrician researcher dedicated to improving health and quality of life for ill and disadvantaged children. The focus of my Fellowship will be research in three areas: rare childhood diseases, fetal alcohol spectrum disorder, and vaccine-preventable disease, with attention to diagnosis, treatment and prevention. Alignment of my research and clinical work and my experience in evidence-based medicine will facilitate adoption of my research into clinical care and health policy.
Immunisation is second only to clean water and sanitation as a life-saving activity. Vaccine safety is considered to be very important by the general public, the media and the health professions. With so many diseases controlled and now rare, the safety of vaccines assumes greater importance. Research is needed on new and safer vaccines, using e.g. a needle-free approach, against old foes, like influenza, and new enemies (like MERS) with vaccine safety more important than ever.
Determinants Of The Outcomes From Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$532,630.00
Summary
Professor Lloyd will continue studies of the factors which lead to varied clinical outcomes from common infectious diseases. The outcomes include chronic or persistent illness, rather than prompt recovery. The factors being studied include aspects of the microbes causing the infection; and aspects of the individual suffering from infection, including genetic make-up, immune defences, and treatment responses. The infections studied include common "flu-like" illnesses, as well as hepatitis C.
Pathophysiology And Treatment Of Malaria And Other Tropical Infectious Diseases Prevalent In Our Region
Funder
National Health and Medical Research Council
Funding Amount
$560,284.00
Summary
Nick Anstey is internationally recognised for his discoveries in malaria and other tropical infectious diseases. He leads a major tropical infectious disease research program in Darwin and SouthEast Asia that attracts some of the brightest researchers and students from Australia and beyond to understand disease mechanisms and work on new ways to treat illness and prevent death. He uses results to change policy and practice not only in Australia but around the world.