I am a public health physician and medical parasitologist determining the mechanism of clinical immunity to malaria, and working on the development of vaccines and therapies against malaria.
This project uses latest genomic technologies to advance our understanding of how bacteria cause disease and finding new antibiotics/approaches to stop the spread of multi-drug resistant hospital superbugs.
Integration Of Biostatistics And Mathematical Modelling To Improve The Control Of Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$622,655.00
Summary
Improving the control of infectious diseases requires the evaluation of interventions that prevent disease at the population level and successfully treat infections at the individual level. This proposal brings together advanced biostatistical research with mathematical modelling to discover novel methods for evaluating antimalarial treatments and malaria vaccine candidates, leading to new insights in infectious disease control and building capacity in this emerging cross-disciplinary field.
This Fellowship will provide support for the Marshall Centre which is providing research and research training in the fields of bacteriology, epidemiology and vaccinology. It has significant regional collaborative links. Molecular epidemiology and pathogenesis of Helicobacter pylori, the stomach bacteria which causes ulcers and for which Warren and Marshall won the 2005 Nobel Prize in Medicine. Development of animal models to study the immune response so that the new bacterium can be used as a v ....This Fellowship will provide support for the Marshall Centre which is providing research and research training in the fields of bacteriology, epidemiology and vaccinology. It has significant regional collaborative links. Molecular epidemiology and pathogenesis of Helicobacter pylori, the stomach bacteria which causes ulcers and for which Warren and Marshall won the 2005 Nobel Prize in Medicine. Development of animal models to study the immune response so that the new bacterium can be used as a vaccine delivery agent.Read moreRead less
Spatiotemporal Risk Assessment Of Emerging Infectious Disease Threats To Australia
Funder
National Health and Medical Research Council
Funding Amount
$641,204.00
Summary
Emerging infectious diseases (EIDs) such as dengue and influenza pose a constant and growing threat to Australians. We live in an increasingly connected world in which EIDs cross borders and oceans, carried by infected people or vectors. This research will build an evidence base for allocation of resources to surveillance and preventive health programmes aimed at mitigating the threat of EIDs, through identifying high-risk sources, routes of introduction, incursion locations and communities.
System-based Approaches To Inform The Design Of Immunotherapies And Immunodiagnostics Against Chronic Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$849,540.00
Summary
Chronic infectious diseases such as malaria are responsible for an enormous public health burden worldwide. New approaches to develop effective interventions against such pathogens are urgently required. Over the next 5 years, I will use innovative genome-based and systems-levels approaches to discover novel pathogen antigens and host immune pathways that underlie protective immunity, immunomodulatory pathways that can be then targeted for intervention, and biomarkers of immunity or disease.
I am an infectious diseases physician and virologist/immunologist focused on developing and testing vaccines against the AIDS virus. I intend to achieve this by advancing novel vaccine concepts that stimulate broad and potent immunity and evaluating these vaccines in rigorous laboratory models and then moving them towards clinical trials.
Manipulating The Fine-turning Of The Innate Immune Response In Disease
Funder
National Health and Medical Research Council
Funding Amount
$938,910.00
Summary
I am an international expert on the body’s first-line defense system, the innate immune response. My Fellowship focuses on studying and manipulating innate immune molecules called interferons. My research will lead to improved management of female reproductive disease, autoimmune disorders, infections and cancer through new diagnostics and therapies targeting the interferon system. The basic knowledge I generate on regulating the immune response will be applicable to a range of medical fields.
Inflammatory Airway Diseases In Children: Mechanisms Underlying And Preventative Strategies
Funder
National Health and Medical Research Council
Funding Amount
$823,008.00
Summary
Professor Sly’s research concentrates on understanding why some children develop chronic lung disease and on finding ways to prevent this from happening.