Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for ....Detection and viability of waterborne pathogens using a gut-on-chip. This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for Cryptosporidium, norovirus and adenovirus. Significant benefits include improved diagnostics and water disinfection assays, improved water treatment and reduced costs with global impact.Read moreRead less
Unravelling cell wall polysaccharide biosynthesis in pathogenic zygomycetes. This project aims to define mechanisms that control cell wall composition and stability in Rhizopus oryzae, a zygomycete fungus responsible for life-threatening human infections. The biochemical properties and function of vital enzymes involved in a newly discovered cell wall polysaccharide biosynthetic pathway will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology an ....Unravelling cell wall polysaccharide biosynthesis in pathogenic zygomycetes. This project aims to define mechanisms that control cell wall composition and stability in Rhizopus oryzae, a zygomycete fungus responsible for life-threatening human infections. The biochemical properties and function of vital enzymes involved in a newly discovered cell wall polysaccharide biosynthetic pathway will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology and structural biology. Expected outcomes include new knowledge on the enzymes that synthesise major fucose-based carbohydrates, to guide the future development of novel strategies for antifungal therapies. The data will also be applicable to animal protection from related zygomycete pathogens.
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Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develo ....Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develop innovative methods to investigate, and importantly modulate, DNA and RNA triple helix assembly, specificity and molecular interactions. Resulting insights will underpin novel approaches to gene regulation, principally in the context of designing new antibacterial agents to address the antibacterial resistance problem.Read moreRead less
Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less
Enhancing Genomic Prediction for Changing Environments in Wheat. Adverse weather is the primary risk faced by the Australian agriculture industry. This Project aims to develop the next generation of agriculture tools to unlock natural potential in wheat and improve yield stability across seasons and regions. Drawing on crop physiology, genetics and integrated modelling, this Project expects to generate new knowledge and technologies to untangle genetic and environmental interactions that affect ....Enhancing Genomic Prediction for Changing Environments in Wheat. Adverse weather is the primary risk faced by the Australian agriculture industry. This Project aims to develop the next generation of agriculture tools to unlock natural potential in wheat and improve yield stability across seasons and regions. Drawing on crop physiology, genetics and integrated modelling, this Project expects to generate new knowledge and technologies to untangle genetic and environmental interactions that affect productivity, enhance predictive capability, and initiate advanced breeding strategies to develop new crop varieties with superior resilience against changing climates. This should provide significant benefits, such as profit stability for wheat growers, elevated global market position and improved food security.Read moreRead less
Whole-genome multivariate reaction norm model for complex traits. This project aims to develop a multivariate whole-genome genotype-covariate correlation and interaction model that can be applied to a wide range of existing genome-wide association study (GWAS) datasets. Genotype-covariate correlation and interaction (GCCI) are fundamental in biology but there is no standard approach to disentangle interaction from correlation in the whole-genome analyses. This project will address the key featur ....Whole-genome multivariate reaction norm model for complex traits. This project aims to develop a multivariate whole-genome genotype-covariate correlation and interaction model that can be applied to a wide range of existing genome-wide association study (GWAS) datasets. Genotype-covariate correlation and interaction (GCCI) are fundamental in biology but there is no standard approach to disentangle interaction from correlation in the whole-genome analyses. This project will address the key feature in biology, which relates to dissecting the complex mechanism of association and interaction. The proposed statistical model implemented in a context of a novel design based on multiple GWAS data sets is a paradigm shifting-tool with applications to multiple industries.Read moreRead less
Multiliteracies for addressing disadvantage in senior school science. Multiliteracies for addressing disadvantage in senior school science. This project aims to develop discipline-specific pedagogies in senior physics, chemistry and biology to improve disadvantaged students’ engagement and achievement. Many students from disadvantaged backgrounds fail to develop the linguistic precision and symbolic representational dexterity needed to comprehend and communicate senior school science concepts. T ....Multiliteracies for addressing disadvantage in senior school science. Multiliteracies for addressing disadvantage in senior school science. This project aims to develop discipline-specific pedagogies in senior physics, chemistry and biology to improve disadvantaged students’ engagement and achievement. Many students from disadvantaged backgrounds fail to develop the linguistic precision and symbolic representational dexterity needed to comprehend and communicate senior school science concepts. These pedagogies will ‘infuse’ multiliteracies in senior school science to improve access to science-based pathways for these students, and enable them to understand progressively more complex scientific concepts and demonstrate this in examinations. This project is expected to improve student retention, arrest declining enrolments in senior school science, and increase young people working in science.Read moreRead less
Enhancing phosphorus use efficiency in macadamia for sustainable production. Macadamia nuts are an iconic native Australian product worth $287 million annually at the farm gate. Phosphorus fertiliser management currently threatens price premiums for sustainable production in high value European Union export markets, and ‘social license’ to farm in their densely populated coastal production areas. The project aims to exploit adaptive root and shoot traits for phosphorus efficiency found in Austra ....Enhancing phosphorus use efficiency in macadamia for sustainable production. Macadamia nuts are an iconic native Australian product worth $287 million annually at the farm gate. Phosphorus fertiliser management currently threatens price premiums for sustainable production in high value European Union export markets, and ‘social license’ to farm in their densely populated coastal production areas. The project aims to exploit adaptive root and shoot traits for phosphorus efficiency found in Australian native plants to optimise phosphorus fertiliser management and set the platform for breeding macadamia root stocks/varieties that require less phosphorus fertiliser. The outcome will be a macadamia industry that is able to maintain current market price premiums and maintain social license to farm in coastal Australia.Read moreRead less
Fine Tuning: A Reconciliation of Indigenous and Western Musical Traditions. Focusing on central Australian song lines, the project strengthens our knowledge, understanding and application of the intricate tuning systems that underpin traditional Indigenous musical practices. Employing a unique methodology that combines Indigenous and contemporary Western musical performance practices with cutting-edge digital technologies, the project will show how the highly nuanced and sophisticated tunings at ....Fine Tuning: A Reconciliation of Indigenous and Western Musical Traditions. Focusing on central Australian song lines, the project strengthens our knowledge, understanding and application of the intricate tuning systems that underpin traditional Indigenous musical practices. Employing a unique methodology that combines Indigenous and contemporary Western musical performance practices with cutting-edge digital technologies, the project will show how the highly nuanced and sophisticated tunings at the heart of Indigenous music-making can be preserved when transposed to contemporary Western art music contexts. In so doing, the case is made for a more genuine, equitable dialogue between Indigenous and non-Indigenous music-makers, to the mutual benefit of musicians, audiences, and society at large. Read moreRead less
Linking for Life: Enhancing pathways to well-being for all Australians. The Linking for Life Project will identify pathways to wellbeing and better social outcomes across the life-course for high-risk/vulnerable individuals and their families to streamline service provision, improve outcomes and identify cost-efficiencies across government agencies. The work will expand cross-sectoral data linkage capability, enhancing research capacity to generate evidence-based policy to improve integrated ser ....Linking for Life: Enhancing pathways to well-being for all Australians. The Linking for Life Project will identify pathways to wellbeing and better social outcomes across the life-course for high-risk/vulnerable individuals and their families to streamline service provision, improve outcomes and identify cost-efficiencies across government agencies. The work will expand cross-sectoral data linkage capability, enhancing research capacity to generate evidence-based policy to improve integrated service delivery across government. The project will also trial innovative data linkage models including the creation of data repositories to improve efficiency for data provision and access, which will have application nationally and enable more timely access to whole-population linked cross-sector data.Read moreRead less