Mental Health Across Generations: Pre-and Post Conception Predicators Of Early Life Risks
Funder
National Health and Medical Research Council
Funding Amount
$666,231.00
Summary
In 2003, mental illnesses were among the ten leading causes of disease burden in Australia, accounting for 13% of the total burden of disease, according to the Australian Institute of Health and Welfare. Mental health problems and mental illness are among the greatest causes of disability, diminished quality of life, and reduced productivity. People affected by mental health problems often have high levels of morbidity and mortality, experiencing poorer general health and higher rates of death f ....In 2003, mental illnesses were among the ten leading causes of disease burden in Australia, accounting for 13% of the total burden of disease, according to the Australian Institute of Health and Welfare. Mental health problems and mental illness are among the greatest causes of disability, diminished quality of life, and reduced productivity. People affected by mental health problems often have high levels of morbidity and mortality, experiencing poorer general health and higher rates of death from a range of causes, including suicide. These conditions are significant in terms of prevalence and disease burden, and have far-reaching impacts for families, carers and others in the community. Mental health problems commonly cluster in families. However, few studies have previously been able to investigate the range of ways in which mental disorders may pass from one generation to another. Further, evidence suggests that influences that arise prior to conception may have major effects on early life risks such as development in utero, birth outcomes and early maternal infant bonding. Mental Health across Generations: Pre- and post-conception predictors of early life risks is a unique study that will examine antenatal maternal mental health and risk behaviours during pregnancy. The study will also examine the links between prior maternal mental health and later birth outcomes, and post natal maternal infant bonding. The risk processes to be tested will include genetic, epigenetic (changes in gene expression), physiological and psycho-social parameters.Read moreRead less
Environmental Influences In The Establishment Of The Epigenetic Landscape In Children
Funder
National Health and Medical Research Council
Funding Amount
$695,097.00
Summary
The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells ....The DNA in each of our cells does not exist alone, it is packaged into complex structures called chromosomes, through association with many different proteins. The distribution of these proteins varies along the length of a chromosome depending on the type of cell and this phenomenon is called 'epigenetics', literally meaning 'above the DNA'. Epigenetic analysis is the study of how proteins and other molecules can change the activity of a gene without changing the DNA sequence. All of our cells use epigenetic changes to help control how they grow and develop. Evidence suggests a direct link between diet and environmental influences on our epigenetic profile. Recent research has traced the origins of many of the health problems of adult life back to the earliest periods of development _ to the time spent in the womb and the first few years of life. If we are born with a low birth weight, we are more likely to get sick later in life. Overwhelming evidence exists that the environment in the womb is critical for a healthy birth weight (and health in later life) and it is thought that epigenetics may be the missing link between this environment, low birth weight, and therefore health in later life. In addition, mounting evidence supports a general link between epigenetic de-regulation and predisposition to disease. However, the timing and the overall contribution of environmental- genetic influences to the establishment of faulty epigenetic markings remain largely unknown. Twins are the best model to study this link as they share similar (but not identical environments) and some share identical genetic makeup. Using twins, Dr Jeffrey Craig and his team will investigate the factors in the prenatal environment that modify specific cells, leading to low birth weight and increase disease risk later in life. They predict that this occurs via specific changes in gene activity caused by epigenetic disruption.Read moreRead less
Special Research Initiatives - Grant ID: SR0354823
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
National network for the study of cognitive processes and treatment across the phases of schizophrenia. Schizophrenia is associated with great costs to the community and individual. Controlled studies have demonstrated Cognitive Behaviour Therapy (CBT) is efficacious in treating symptoms of schizophrenia. Studies of cognitive processes have also advanced understanding of psychotic phenomena. This initiative affords the opportunity to
1) Improve treatment efficacy by developing, testing and appl ....National network for the study of cognitive processes and treatment across the phases of schizophrenia. Schizophrenia is associated with great costs to the community and individual. Controlled studies have demonstrated Cognitive Behaviour Therapy (CBT) is efficacious in treating symptoms of schizophrenia. Studies of cognitive processes have also advanced understanding of psychotic phenomena. This initiative affords the opportunity to
1) Improve treatment efficacy by developing, testing and applying theoretically-driven models of psychotic symptoms.
2) Disseminate the findings of research on CBT for psychotic disorders in clinical settings by (a) training the work-force, and (b) facilitating CBT delivery in routine practice.
3) Apply CBT in various settings with a variety of psychotic populations to test its effectiveness in routine clinical settings.
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Internet technologies, health informatics and statistical methods, and new delivery platforms in call centres. Although depression is the major cause of health disability, 60% of Australians with depression do not receive professional help. There are few systems for delivering health information and resilience skills to members of the community. This project aims to develop a workable system to reduce unmet need. It will provide a model of information delivery applicable to other areas of the ....Internet technologies, health informatics and statistical methods, and new delivery platforms in call centres. Although depression is the major cause of health disability, 60% of Australians with depression do not receive professional help. There are few systems for delivering health information and resilience skills to members of the community. This project aims to develop a workable system to reduce unmet need. It will provide a model of information delivery applicable to other areas of the health industry, particularly those involving chronic disease. It has applicability to education and other sectors which involve the delivery of information to the public. Because e-health is an emerging field, the project also has the capacity to build expertise in an area which is under-resourced. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150100637
Funder
Australian Research Council
Funding Amount
$322,534.00
Summary
Finding the Path: Service access and navigation for serious mental illness. This project aims to inform health system change to ensure people with serious mental illness can access quality services. While improved access to quality mental health services has been a key target in Australian health policy for over 20 years, people with mental illness continue to report problems accessing and navigating the complex service system. The project aims to study consumers' mental health service experienc ....Finding the Path: Service access and navigation for serious mental illness. This project aims to inform health system change to ensure people with serious mental illness can access quality services. While improved access to quality mental health services has been a key target in Australian health policy for over 20 years, people with mental illness continue to report problems accessing and navigating the complex service system. The project aims to study consumers' mental health service experiences using policy, qualitative, quantitative and geographic analysis to identify systemic problems. Mental health consumers and service providers will be actively involved in developing final policy recommendations to ensure system change reflects their knowledge.Read moreRead less
A new quality of life instrument with older people for economic evaluation. This project aims to develop and validate a new preference-based quality-of-life instrument with applications in aged-care. The new instrument will be developed with older people receiving aged care services, and will focus upon incorporating their values into the measurement and valuation of quality of life for economic evaluation. The new instrument will have immediate applications in quality assessment and economic ev ....A new quality of life instrument with older people for economic evaluation. This project aims to develop and validate a new preference-based quality-of-life instrument with applications in aged-care. The new instrument will be developed with older people receiving aged care services, and will focus upon incorporating their values into the measurement and valuation of quality of life for economic evaluation. The new instrument will have immediate applications in quality assessment and economic evaluation, improving the quality of life and wellbeing of older Australians, and will assist in determining the relative cost effectiveness of new and existing services.
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Ageing in China and Australia: Promoting health, productivity and wellbeing. This project aims to provide insights into the ways in which life-span development and social change in China have influenced the development of policies to support the health, productivity and wellbeing of people entering later life. China’s population is rapidly ageing, bringing pressure on intergenerational support arising from smaller families, migration, urbanisation, and growing social inequalities. It may also br ....Ageing in China and Australia: Promoting health, productivity and wellbeing. This project aims to provide insights into the ways in which life-span development and social change in China have influenced the development of policies to support the health, productivity and wellbeing of people entering later life. China’s population is rapidly ageing, bringing pressure on intergenerational support arising from smaller families, migration, urbanisation, and growing social inequalities. It may also bring opportunities. Using an understanding of social determinants, cultural context and policy responses, the project plans to undertake cross-national comparisons with Australia and examine historical influences and social variations within China. The project aims to deliver a better understanding of how public policy can enhance productivity, health and wellbeing of an ageing population.Read moreRead less
Trust makers, breakers and brokers: building trust in the Australian food system. This research will compare and contrast the way that food trust is managed in Australia and the United Kingdom, with a particular focus on how trust is damaged and repaired. Using consensus-testing processes, best practice models will be developed to assist government, industry, media and consumer groups to build and maintain trust in the food supply.
A disease of the brain: how do neurobiological explanations of addiction influence the attitudes and behaviour of smokers? This project explores the impact of promoting addiction as a "brain disease" on smokers' confidence in their ability to quit smoking, and the methods they use to quit. This is essential to inform public health policies designed to reduce the burden of tobacco related harms.
The impact and cost of short-term health staffing in remote communities. This project aims to examine the impact of the increasing levels of short-term health staffing in remote communities upon service acceptability to patients, workload and attitudes of long-term resident primary health care staff, and the effectiveness and cost of health services. There is a dearth of information about this 'fly in/fly out' (FIFO) workforce in remote communities, which have the worst health outcomes in the co ....The impact and cost of short-term health staffing in remote communities. This project aims to examine the impact of the increasing levels of short-term health staffing in remote communities upon service acceptability to patients, workload and attitudes of long-term resident primary health care staff, and the effectiveness and cost of health services. There is a dearth of information about this 'fly in/fly out' (FIFO) workforce in remote communities, which have the worst health outcomes in the country. The project aims to inform consumers, health practitioners, health service planners and policy-makers about the impact of FIFO, as well as to contribute to the development of strategies designed to stabilise the remote health workforce.Read moreRead less