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Neurodevelopmental Outcomes After Novel Interventions In Newborn Infants
Funder
National Health and Medical Research Council
Funding Amount
$188,226.00
Summary
Children who were sick in the newborn period or born preterm are at increased risk of abnormal development, particularly problems with their ability to walk, think and learn. This research will assess how new treatments affect sick newborns’ later development. For example, giving preterm babies healthy germs, or probiotics, decreases a serious bowel infection, called necrotising enterocolitis or NEC. This research will find out if they also help preterm brain development when the children are 2 ....Children who were sick in the newborn period or born preterm are at increased risk of abnormal development, particularly problems with their ability to walk, think and learn. This research will assess how new treatments affect sick newborns’ later development. For example, giving preterm babies healthy germs, or probiotics, decreases a serious bowel infection, called necrotising enterocolitis or NEC. This research will find out if they also help preterm brain development when the children are 2 years old.Read moreRead less
Evaluating Neonatal And Child Health Interventions For Evidence Based Planning And Practice In Low Resourced Countries
Funder
National Health and Medical Research Council
Funding Amount
$410,512.00
Summary
The overall aim is to develop a neonatal and child health research programme responding to the various needs of resource poor country governments and provide an evidence base for public and clinical interventions and health programming. One neonatal study is outlined evaluating alternative phototherapy treatment for neonatal jaundice.
Improving Neonatal Transition For Compromised Infants And Minimising Lung Injury
Funder
National Health and Medical Research Council
Funding Amount
$188,226.00
Summary
The projects in this proposal are designed to improve the health of newly born infants before they are born (fetal lactate blood test to assist in decision making), at birth (randomized clinical trials to provide evidence for future resuscitation guidelines) and in the first few hours following preterm birth by studying alternative methods of providing existing therapies for neonatal respiratory distress syndrome. These studies may prevent harm and allow a “Healthy start to life”.
Towards Improved Respiratory Outcomes In Preterm Infants Through Rapid And Effective Aerosalisation Of Medication To The Lung
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Babies born premature are greatest at risk from increasingly common respiratory illnesses. It is possible that delivering a medication by aerosol will be the most effective method of treatment. For premature babies that need breathing support, inhaled medication could improve care. For highly infectious respiratory illnesses such as RSV, with no vaccines available, we need to protect babies very early in life. I will use an established lamb model to test fast medication delivery to the lungs.
Role Of Placental Heme-oxygenase Pathway In Regulating Preterm Neonatal Cardiovascular Function
Funder
National Health and Medical Research Council
Funding Amount
$176,719.00
Summary
Babies born prematurely are more likely to experience problems as a result of being born early with males doing worse than females. The mechanisms causing this difference are unknown. The control of blood flow in the placenta and fetus is essential for normal growth and development. This project will investigate the influence of duration of pregnancy, gender, and exposure to antenatal steroids on pathways that control blood flow in the placenta and the newborn in babies born after prematurely.
Obesity During Pregnancy: How Can We Improve Health Outcomes For Women, Infants And Children?
Funder
National Health and Medical Research Council
Funding Amount
$376,449.00
Summary
Obesity is a common issue facing Australian women and has a role to play in health in pregnancy, birth and later life for the woman and her children. Providing interventions for better health during pregnancy is likely to be an important factor in improving outcomes for a woman and her infant, both at the time of pregnancy and in later life.
Early Introduction Of Foods Into Infant Weaning Diets To Induce Oral Tolerance And Prevent Food Allergies.
Funder
National Health and Medical Research Council
Funding Amount
$143,660.00
Summary
Food allergies can be life threatening, and with no treatment, prevention is crucial. Traditional advice for babies whose parents have allergies has been to delay the introduction of allergy causing foods. However, recent research has questioned this approach. In this study I plan to investigate whether the early introduction of fish and eggs in the weaning diet can reduce the incidence of allergy. The results will be crucial to determine the best approach to reduce the risk of food allergy.
Combinatorial Therapeutics In High-risk Infant Acute Lymphoblastic Leukaemia
Funder
National Health and Medical Research Council
Funding Amount
$340,891.00
Summary
Modern therapies for children with leukaemia are curative in more than 90%. In contrast, survival for infants less than one year of age at the time of diagnosis is less than 50%. Better therapies are desperately needed. From laboratory testing we have discovered effective novel cancer drugs, which are not currently used for treatment of babies with leukaemia. We will evaluate novel drug combinations and test them in model systems, such that they can be fast-tracked to the clinic.