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Cognitive Improvement Through Early Restoration Of CirCADian Rhythms In Very Preterm Infants Via Environmental Modification: The CIRCA DIEM Study
Funder
National Health and Medical Research Council
Funding Amount
$3,077,039.00
Summary
When very premature infants are born, they no longer receive important signals from their mother about whether it is daytime or night-time, and are cared for in hospital environments that are noisy and brightly lit all day. The absence of the maternal signals and the constant light and noise may interfere with normal brain development. We will determine if wearing eye masks and ear muffs at night in hospital will improve brain development and general health in premature babies.
Intermittent Preventive Treatment In Pregnancy With Sulphadoxine-pyrimethamine Plus Dihydroartemisinin-piperaquine To Reduce Adverse Pregnancy Outcomes And Prevent Malaria In Papua New Guinea: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$2,938,453.00
Summary
Millions of pregnancies are complicated by malaria worldwide. Monthly sulphadoxine-pyrimethamine (SP) treatments, the current treatment strategy, no longer protects from malaria but improves birth outcomes through non-malarial effects. Dihydroartemisinin-piperaquine clears malaria but babies are smaller compared to women who received SP. A clinical trial of their combination has potential to substantially improve health outcomes for women and babies in Papua New Guinea and beyond.