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Improving The Health And Development Of High Risk Preterm Newborns
Funder
National Health and Medical Research Council
Funding Amount
$338,381.00
Summary
Preterm children have more health and developmental problems than those born full term. Although we know the problems faced by those tiniest and most immature, more questions remain. What problems do they face as adults? What new treatments are available to improve their outcomes? Are the more “mature” preterms at risk as well? My research program aims to address these questions through the efforts of the Victorian Infant Collaborative Study team, a large research team that I lead.
Fetal And Neonatal Therapy To Improve Perinatal Outcome And Long-term Neurodevelopment
Funder
National Health and Medical Research Council
Funding Amount
$214,032.00
Summary
I am a consultant neonatologist with a half-time research appointment. Preventing perinatal morbidity and mortality is one of the greatest challenges in medicine today. My vision is to lead research into new fetal and neonatal therapies, foster collaborations with clinicians and scientists, and improve clinical practice. The scope of my research includes “brain-oriented” program of neonatal intensive care, neuroprotective strategies, and devising new fetal together with the obstetricians.
The Cellular And Molecular Mechanisms In The Initaition Of Human Labour
Funder
National Health and Medical Research Council
Funding Amount
$460,904.00
Summary
Being born too early is the major cause of perinatal morbidity and mortality and accounts for the majority of neonatal deaths. The aim of this project is to gain a better understanding of the mechanisms involved in premature birth with a view to future development of clinically useful interventions to reduce the high rates of mortality and long-term disability.
Understanding The Biology Of Pregnancy To Prevent Morbidity And Mortality
Funder
National Health and Medical Research Council
Funding Amount
$422,746.00
Summary
Progress in the care of the unborn baby, and thus optimisation of life-long health, will only come with a greater understanding of the fundamental processes that underlie pregnancy. My research is aimed at saving babies lives and reducing the long-term burdens (health, emotional and economic) of major perinatal conditions. I am uniquely placed to carry out this research, using the research tools I have developed to deliver real outcomes that will change clinical practice
Understanding Typical And Atypical Development Of The Infant Brain
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
This project will apply advanced magnetic resonance imaging (MRI) techniques to understand how brain abnormalities in preterm infants relate to their functional impairments. It aims to: develop new software to easily and accurately measure infant brain structures and tissues; understand the neurobiological basis for adverse outcomes, enabling diagnosis of high risk preterm infants; and identify MRI biomarkers to assess interventions designed to give Australian babies a healthier start to life.
Protecting Newborn Brains Via Innovative Monitoring Technology
Funder
National Health and Medical Research Council
Funding Amount
$394,460.00
Summary
This project aims to develop innovative brain monitoring technology which could help minimise brain damage in newborn babies with brain injuries, thereby delivering a healthier start to life. Such novel technology may automatically analyse babies’ brain activity and deliver instant detection of critical abnormalities, which could enable more effective treatment of brain injuries. Babies with reduced oxygen or blood supply to the brain and premature babies could benefit from such innovations.
The Early Origins Of Obsteric Diseases: Biological Investigations And Biomarker Discovery
Funder
National Health and Medical Research Council
Funding Amount
$282,290.00
Summary
Recent evidence has pointed to the beginning of pregnancy as the time when biological cascades begin that cause common diseases of pregnancy. This opens the door to developing bloods test in early pregnancy predicting who will develop problems, and to hunt for novel proteins in the bloodstream that are causing the illnesses. 'Proteomic technology' will be used, a new cutting edge tool that can scan the entire protein pool in mum's blood in a single experiment.
Reducing Perinatal Lung, Heart And Brain Injury In Preterm Infants – From Bench To The Clinic.
Funder
National Health and Medical Research Council
Funding Amount
$463,652.00
Summary
Many infants are exposed to an adverse environment whilst developing in the womb, and are therefore at increased risk of lung, heart and brain injury, with life-long consequences. This research is focused on improving the entry into the world of vulnerable infants, thus reducing the risk and severity of brain injury.
Optimising Asthma Management In Pregnancy For Optimal Infant Health
Funder
National Health and Medical Research Council
Funding Amount
$428,065.00
Summary
Asthma affects 12% of pregnant women in Australia. These women are at increased risk of poor pregnancy outcomes, such as preterm birth and hospitalisation of the neonate. Reducing asthma attacks by providing optimal asthma management during pregnancy may lower these risks. This research will test whether a strategy which determines treatment changes based on a marker of airway inflammation, improves outcomes for maternal, neonatal and child health.