I am a clinical scientist conducting translational and implementation research to improve diagnosis, management and understanding of airway diseases including asthma, COPD (chronic obstructive pulmonary disease), bronchiectasis and persistent cough.
Through the Australia Fellowship Prof Mattick will lead a team of researchers to explore the scientific and applied dimensions of the thesis that the human genome is not largely comprised of evolutionary debris, but encodes an extraordinarily sophisticated information suite that is largely transacted by RNA. The work will include examination of the expression patterns on noncoding RNAs in different tissues and cells and different disease states, exploration of the location and dynamics of RNAs a ....Through the Australia Fellowship Prof Mattick will lead a team of researchers to explore the scientific and applied dimensions of the thesis that the human genome is not largely comprised of evolutionary debris, but encodes an extraordinarily sophisticated information suite that is largely transacted by RNA. The work will include examination of the expression patterns on noncoding RNAs in different tissues and cells and different disease states, exploration of the location and dynamics of RNAs associated with DNA and various proteins to determine how these RNAs influence gene expression, targeted functional analyses of selected subsets of these RNAs to determine their biological function as proof-of-principle for others, exploration of the roles of RNA editing proteins, and testing of the hypothesis that RNA-directed DNA recoding might underpin memory formation. If correct, the results of the project will transform our understanding of human biology, development, and brain function, and create an enlightened framework for future research into human health and disease.Read moreRead less
I am a molecular biologist determining the mechanisms of eukaryotic mRNA translation and its regulation by RNA-binding proteins and noncoding RNA. In collaborative work I extend these basic science objectives into the medical research areas of cardiology
I am a cell-molecular biologist studying the role and regulation of the plasminogen activating (fibrinolytic) system in health and disease. My recent studies have defined a novel role for tissue-type plasminogen activator in the central nervous system and
My aim is to use advanced Neuroimaging to further our understanding of the pathophysiology of brain disorders, in particular Epilepsy, but also Sleep disorders, Schizophrenia, the Dementias. In the case of my main research interest (Epilepsy) it is to red