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Telehealth And Advanced CT Imaging Combined Study (TACTICS)
Funder
National Health and Medical Research Council
Funding Amount
$979,270.00
Summary
This project aims to converge several acute stroke therapy systems of care to provide the best possible health outcomes for patients living in regional areas. We will implement a proven telehealth program with the aim of providing increased access to thrombolysis through screening with multimodal CT. During this project we will also undertake a nested randomised trial of advanced imaging to identify which is the most efficient imaging protocol to ensure the best possible patient outcomes
While there are numerous therapies for relapsing-remitting multiple sclerosis (MS), therapy for progressive MS remains elusive. This project will evaluate the effect of various therapies on the accumulation of irreversible disability in progressive MS. In addition, it will examine the effect of switching between therapies on MS activity. Finally, the project will indicate whether demographic and clinical information can be used as a predictor of individual patient response to MS therapies.
Investigating Implementation Of 2017 Stroke Clinical Guidelines In Inpatient Stroke Rehabilitation
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
There are major problems in Australia and overseas of patients not receiving evidence-based care. In the first 3 months after a stroke, receiving more therapy helps people improve. People in stroke rehabilitation should receive 3 hours therapy/day, but this does not usually happen. This project will use rigorous research methods to work with stroke survivors, their carers and staff in rehabilitation hospitals to find the best way to ensure that each stroke survivor does 3 hours of practice/day.
Individualizing Cytomegalovirus Preventative Strategies Following Solid Organ Transplantation: A Precision Medicine Approach
Funder
National Health and Medical Research Council
Funding Amount
$128,224.00
Summary
Cytomegalovirus (CMV) infection is a significant contributor to poor outcomes following solid organ transplantation. Current preventative strategies are somewhat effective but treat groups of patients similarly rather than targeting the individual, so many patients are treated unnecessarily & breakthrough disease still occurs. We propose a program of research directed towards individualizing CMV prevention strategies in solid organ transplant recipients, incorporating new diagnostic tests.
Precision Treatment For Multiple Sclerosis: Maximising The Effect Of Immunomodulatory Therapy
Funder
National Health and Medical Research Council
Funding Amount
$537,272.00
Summary
Response to therapy varies greatly among patients with multiple sclerosis (MS). The current lack of individualised MS therapy may lead to suboptimal MS management and accumulation of preventable disability. We will use MSBase, a large international MS cohort, to evaluate the effect of different treatment strategies and of highly effective and novel therapies. Identifying the patients who will benefit from these therapies, we will provide the key evidence for individualised MS management.
Modernizing The Knowledge Base For Reproductive Health Care: Individual Patient Data Meta-analysis As The New Standard For Evidence Synthesis In Reproductive Health.
Funder
National Health and Medical Research Council
Funding Amount
$575,662.00
Summary
Characteristics of sick persons differ, and criteria that have been used to include them in studies may not match the individual profile of individuals who typically present to the health system. I propose a step towards more personalised medicine, which is new in the field of reproductive health. In a global collaboration, we plan to collect individual participant data of studies, and develop clinical rules and guidelines that tailor the individual profile of the sick individual.
Personalised Brain Stimulation For Treatment Of Obsessive-Compulsive Disorder
Funder
National Health and Medical Research Council
Funding Amount
$666,128.00
Summary
Obsessive-Compulsive Disorder (OCD) affects more than 230,000 Australians, 25% of whom attempt suicide. This project will use a novel method to profile people with OCD based on patterns of brain activity and symptoms, and assess if such profiling can improve the efficacy of brain stimulation interventions for OCD. Results from this study will provide evidence supporting the use of personalised brain stimulation as a viable therapy for OCD.
A Prospective Clinical Trial To Establish The Significance Of Interim FDG And FLT PET/CT Scans As Biomarkers Of Patient Prognosis And Individualised Radiation Therapy In Non-small Cell Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$532,902.00
Summary
Positron Emission Tomography (PET)/Computed Tomography (CT) scanners pinpoint the location of cancer cells in people prior to and after treatment. This innovative study will use during treatment PET/CT scans to establish the response of lung tumours to radiation therapy (RT). We will use these scans to simulate the delivery of highly targeted, individualised RT and to predict patient prognosis, with the ultimate aim of increasing survival and minimising side effects in patients with lung cancer
The Role Of The Acute Phase Response In Docetaxel Resistance In Hormone-refractory Prostate Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$74,365.00
Summary
Prostate cancer is the most common cancer in Australian men. Chemotherapy is used in advanced disease, but is only effective in ~50% of patients. In the first year of my PhD, I identified 8 plasma biomarkers that predict chemotherapy resistance. I plan to characterise how these immune molecules cause chemotherapy resistance using a mouse model of advanced prostate cancer. These markers may allow us to personalise prostate cancer treatment in the future and identify more effective therapies.
Outcomes Of Treatment Decisions And Prediction Of Individual Treatment Response In Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$92,358.00
Summary
Multiple sclerosis is the most common cause of neurological disability among young people. With the increasing choice of therapies, the goal of freedom from disease has become more realistic. We will use the MSBase international multiple sclerosis registry to identify optimal, individually-tailored therapeutic strategies. We will also implement volumetric magnetic resonance imaging in routine practice, thus translating a research tool into an instrument available to patients and their doctors.