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I am a neuroscientist translating basic knowledge on the enteric nervous system into new therapies for children with previously untreatable bowel motility disorders. I am heading a multidisciplinary group of clinicians and scientists leading the world in
Sacral Parasympathetic Innervation Of Distal Bowel
Funder
National Health and Medical Research Council
Funding Amount
$314,983.00
Summary
Not a topic for polite conversation, normal movements of the colon and rectum are essential for good health and a sense of wellbeing. Constipation, diarrhoea, incontinence and pain result from disordered motility. One major control mechanism is the parasympathetic innervation. While we know of its importance, how it works in health and diseases is poorly understood. This project will use state-of-the-art techniques to study this pathway in order to understand its role in health and disease
A Trial Of A Multidisciplinary, Group Based Intervention To Meet The Needs Of Men With Prostate Cancer
Funder
National Health and Medical Research Council
Funding Amount
$524,285.00
Summary
This study will test an innovative approach to meeting the physical and psychosocial needs of men with early stage prostate cancer using a randomised controlled trial. This novel approach involves a combination of individual and group-based consultations which encourages peer-to-peer support, promotes self-care and enhances appropriate multidisciplinary referrals and communication. It provides a new model of care for patients with chronic diseases that can be translated into clinical practice.
A significant proportion of mothers give birth assisted by forceps or vacuum extraction (Ventouse) when problems occur during labour. A number of problems such as incontinence, haemorrhoids, persistent perineal pain, incontinence and sexual problems seem to be commoner after birth in mothers who have had an operative vaginal birth. It has been suggested that to avoid these problems more women should have an elective caesarean without going through labour at all. Although caesarean births would p ....A significant proportion of mothers give birth assisted by forceps or vacuum extraction (Ventouse) when problems occur during labour. A number of problems such as incontinence, haemorrhoids, persistent perineal pain, incontinence and sexual problems seem to be commoner after birth in mothers who have had an operative vaginal birth. It has been suggested that to avoid these problems more women should have an elective caesarean without going through labour at all. Although caesarean births would probably avoid the problems listed above caesarean births are not necessarily better for women's health in all ways - and they are much more costly. This study will follow-up 990 women who had an operative birth (vaginal or caesarean) in 1996-8, 'debriefing' after birth and assessment of health status and health problems 6 months after birth. It will assess their subsequent recovery and fertility, review the events of pregnancy, labour and birth in their medical records to identify factors associated with incontinence, perineal pain, haemorrhoids and sexual problems, and review the outcome of any pregnancies since the original study. The study will provide: * better long term information about health problems, recovery, and fertility after caesarean birth and after operative vaginal birth; * stronger evidence on factors during labour associated with incontinence and related problems; * documentation of the reasons why women with incontinence and related problems rarely seek help or treatment from GPs or specialists; * evidence of any long-term effects of 'debriefing' after birth.Read moreRead less
Maternal Health After Childbirth: A Prospective Cohort Study Of 1900 Nulliparous Women Recruited In Early Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$697,150.00
Summary
Recent research highlights a concerning burden of ill health in recent mothers. Common health problems in the year after birth are chronic exhaustion, persisting pain, urinary incontinence, bowel problems, sexual problems and depression. This study will investigate the incidence, onset, severity and duration of health problems in the first 18 months after childbirth. A major focus of the study will be on the extent to which common health problems affecting women after childbirth occur as new pro ....Recent research highlights a concerning burden of ill health in recent mothers. Common health problems in the year after birth are chronic exhaustion, persisting pain, urinary incontinence, bowel problems, sexual problems and depression. This study will investigate the incidence, onset, severity and duration of health problems in the first 18 months after childbirth. A major focus of the study will be on the extent to which common health problems affecting women after childbirth occur as new problems in pregnancy, or after childbirth. This involves following women having a first child and measuring their health in pregnancy and the first year after birth. 1900 women having a first birth will be recruited to the study in early pregnancy, and followed up until 18 months after the birth. A major aim of the study is to provide stronger evidence about the role of pregnancy and birth factors in physical health problems after birth. In particular, the study will examine the contribution of method of delivery to pelvic floor disorders (urinary and anal incontinence, perineal pain and sexual problems). The study will also examine reasons why many women choose not to discuss physical and emotional health problems with health professionals in the postnatal period. The influence of cultural, social and economic factors on health service use and disclosure of maternal health problems will be explored. The study will provide the first Australian data on new health problems experienced for the first time after childbirth, and the extent to which pregnancy, labour and birth contribute to subsequent ill-health. The findings will provide stronger evidence on which to base the care of women during childbirth,development and evaluation of primary and secondary prevention strategies, and information to women and their families regarding the risks of obstetric procedures, such as caesarean section and vaginal birth assisted with forceps.Read moreRead less
Development Of A Rapid, Non-invasive And Biocompatible Bedside Sensing Method For Jaundice Embedded In A Newborn Nappy
Funder
National Health and Medical Research Council
Funding Amount
$541,744.00
Summary
Severe jaundice is a life threatening condition for which an effective screening tool in infants is currently unavailable. There is an urgent need to identify a suitable, reliable and affordable bedside test to positively impact upon the lives of millions of children worldwide by facilitating effective early intervention. This project will validate a non-invasive, affordable bedside test for neonatal jaundice, using a urine test positioned in a newborn’s nappy.
A Practical New Method Of Measuring Population Salt Intake
Funder
National Health and Medical Research Council
Funding Amount
$327,193.00
Summary
The World Health Organization has set a target for member countries to reduce salt intake by 30% by 2025. Key to this is measurement of population salt intake. Collection of 24-hour urine samples is the gold standard used to estimate salt intake but this method is burdensome. Collection of a single urine sample is an alternative method. This project will bring together all of the available data worldwide to assess the reliability of using a single urine sample to measure population salt intake.