Effects Of The Fatty Acid, Lauric Acid, On Energy Intake And Gut Motor And Hormonal Function In Health And Obesity
Funder
National Health and Medical Research Council
Funding Amount
$744,645.00
Summary
Obesity is largely due to energy intake exceeding energy expenditure, thus, strategies that reduce energy intake will result in weight loss. We discovered recently that the fatty acid, lauric acid, markedly reduces energy intake. Our studies will determine the effects of lauric acid on energy intake and body weight reduction in obese subjects. The research is a new initiative and explores the potential of lauric acid as a novel, nutrient-based and side-effect free approach to obesity management.
Understanding, controlling and improving the flavour of almond kernels. Almond kernels may be sweet, semi-bitter or bitter, with the first two categories marketed as fresh nuts, while the latter are used in processed products such as marzipan. Semi-bitter kernels have a more interesting flavour than sweet kernels and we require tools to breed for this character. The bitter flavour is imparted by amygdalin via the cyanogenic pathway. This project will characterise the genetic control of sweet, ....Understanding, controlling and improving the flavour of almond kernels. Almond kernels may be sweet, semi-bitter or bitter, with the first two categories marketed as fresh nuts, while the latter are used in processed products such as marzipan. Semi-bitter kernels have a more interesting flavour than sweet kernels and we require tools to breed for this character. The bitter flavour is imparted by amygdalin via the cyanogenic pathway. This project will characterise the genetic control of sweet, semi-bitter and bitter flavour, amygdalin accumulation in developing kernels, and key enzymes in the cyanogenic pathway. Almond populations segregating for these traits will be used and the data will be integrated into the Australian almond meiotic map.Read moreRead less
Microsatellite marker development for almond breeding. Australian almond growers produce 8,000 tonnes of kernel annually, and the long term aim is to develop strong export markets. The industry funds a breeding program at Adelaide University, comprising hybridisation and selection. Through our current ARC SPIRT grant we augment this with a program in molecular techniques. Research is well-advanced in the development of a genetic map for almond based on both molecular and agronomic characters. ....Microsatellite marker development for almond breeding. Australian almond growers produce 8,000 tonnes of kernel annually, and the long term aim is to develop strong export markets. The industry funds a breeding program at Adelaide University, comprising hybridisation and selection. Through our current ARC SPIRT grant we augment this with a program in molecular techniques. Research is well-advanced in the development of a genetic map for almond based on both molecular and agronomic characters. This IREX grant will facilitate integration of our map with the International Prunus mapping program, based at Cabrils, Spain. It will also facilitate augmentation of the map with jointly-developed microsatellite markers.Read moreRead less
Investigation of almond transformation for self-fertility and virus resistance. This project addresses the long-term goal of the Australian almond industry to produce cultivars that are self-fertile and resistant to Prunus necrotic ringspot and prune dwarf viruses. Both self-sterility and virus infection can result in unreliable and often low yields. Research will address the control of gene expression relating to self-sterility and the introduction of virus resistance, via sequencing of self- ....Investigation of almond transformation for self-fertility and virus resistance. This project addresses the long-term goal of the Australian almond industry to produce cultivars that are self-fertile and resistant to Prunus necrotic ringspot and prune dwarf viruses. Both self-sterility and virus infection can result in unreliable and often low yields. Research will address the control of gene expression relating to self-sterility and the introduction of virus resistance, via sequencing of self-fertility and self-sterility genes, construct development and improved regeneration of transformed almond in vitro without the use of antibiotics.Read moreRead less
Molecular switches and genetic consequences of grain retention in cereals. Grain retention at maturity was key for crop domestication and laid the basis for farming. Wheat and barley have evolved a novel mechanism for ensuring grain retention and, although the genes are known, the mechanisms for action are not. Grain dispersal in the wild relatives involves highly targeted changes in the walls of a small number of cells. This project will explore how the two identified genes control this proces ....Molecular switches and genetic consequences of grain retention in cereals. Grain retention at maturity was key for crop domestication and laid the basis for farming. Wheat and barley have evolved a novel mechanism for ensuring grain retention and, although the genes are known, the mechanisms for action are not. Grain dispersal in the wild relatives involves highly targeted changes in the walls of a small number of cells. This project will explore how the two identified genes control this process and clarify their mode of action. The genes ensuring grain retention have been so critical for domestication that the region surrounding them has become genetically fixed. The project will assess the implication of fixation on genetic diversity and develop options to bring novel variation into breeding programs.Read moreRead less
Ecology, morphology and the diversification of Australian lizards. This project aims to determine the factors driving the spectacular radiation of lizards in Australia. To date, most investigations of lizard anatomy have focused exclusively on external characteristics. This project will examine the underlying internal anatomy to investigate whether morphological innovation is associated with enhanced rates of ecological, life-history and species diversification. The project expects to shed light ....Ecology, morphology and the diversification of Australian lizards. This project aims to determine the factors driving the spectacular radiation of lizards in Australia. To date, most investigations of lizard anatomy have focused exclusively on external characteristics. This project will examine the underlying internal anatomy to investigate whether morphological innovation is associated with enhanced rates of ecological, life-history and species diversification. The project expects to shed light on the evolution of Australia’s most diverse vertebrate lineage, and provide comparative data with which to interpret the lizard fossil record in Australia, and the range declines and relative extinction risks of native lizard species.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100217
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Harnessing Mendel’s workhorse: meiotic crossovers for genetic diversity in crop breeding. Introducing genetic diversity from wild species into elite lines of wheat and barley may increase their resistance to the stresses they are exposed to in the field. Modern breeding cultivars could capture up to ten times more genetic variation. This project aims to gain fundamental insights into the genetic and environmental factors that limit the rates at which new genomic combinations can be made. This wi ....Harnessing Mendel’s workhorse: meiotic crossovers for genetic diversity in crop breeding. Introducing genetic diversity from wild species into elite lines of wheat and barley may increase their resistance to the stresses they are exposed to in the field. Modern breeding cultivars could capture up to ten times more genetic variation. This project aims to gain fundamental insights into the genetic and environmental factors that limit the rates at which new genomic combinations can be made. This will transform wheat and barley breeding methods, unlocking available genetic diversity to produce new varieties. Read moreRead less
Deciphering the genetic regulation of inflorescence development in wheat. The project aims to identify genes and molecular processes that regulate inflorescence architecture in wheat, using state-of-the-art genetic resources to identify novel biological mechanisms that regulate the development of spikelets – reproductive branches that contain grain-producing florets. The research is highly significant as little is known about how spikelet and floret numbers are determined genetically in wheat, a ....Deciphering the genetic regulation of inflorescence development in wheat. The project aims to identify genes and molecular processes that regulate inflorescence architecture in wheat, using state-of-the-art genetic resources to identify novel biological mechanisms that regulate the development of spikelets – reproductive branches that contain grain-producing florets. The research is highly significant as little is known about how spikelet and floret numbers are determined genetically in wheat, and new traits need to be identified to increase yields for the world’s growing population. Project outcomes will include new insights into the biology that underpins grain production of wheat, with expected benefits enabling sustainable increases of yields by breeders and growers to help bolster global food security.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100784
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Improving cereal grain quality using epigenetic regulators. The project aims to determine the epigenetic regulatory mechanisms that control cereal grain quality and yield under water-deficit and heat stress. The project will use next-generation sequencing to identify key epigenetic regulators and their functional target genes, which confer superior grain quality to elite genotypes under adverse environments. Project outcomes will benefit cereal breeding by providing more-tailored screening stra ....Improving cereal grain quality using epigenetic regulators. The project aims to determine the epigenetic regulatory mechanisms that control cereal grain quality and yield under water-deficit and heat stress. The project will use next-generation sequencing to identify key epigenetic regulators and their functional target genes, which confer superior grain quality to elite genotypes under adverse environments. Project outcomes will benefit cereal breeding by providing more-tailored screening strategies and superior parental germplasm with enhanced quality and yield. The development of nutritionally improved crops will benefit the Australian cereal industry and export opportunities.Read moreRead less
Field and quasi-field phenotyping for the quantitative characterisation of wheat yield under stress. The project aims to develop state-of-the-art monitoring and profiling capabilities for the quantitative assessment of plant growth performance in field and quasi-field environments under the abiotic stress conditions of drought and nutrient deficiency. This project involves the design and use of high resolution but low budget imaging stations to capture the growth of cereal plants in competitive ....Field and quasi-field phenotyping for the quantitative characterisation of wheat yield under stress. The project aims to develop state-of-the-art monitoring and profiling capabilities for the quantitative assessment of plant growth performance in field and quasi-field environments under the abiotic stress conditions of drought and nutrient deficiency. This project involves the design and use of high resolution but low budget imaging stations to capture the growth of cereal plants in competitive environments. Novel computer vision and image processing techniques will be applied to the image data to quantitatively characterise the success of genetic varieties to tolerate abiotic stress environments under actual field conditions.Read moreRead less