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Mechanisms Of Regulatory T Cell Induction By Soluble Immunomodulatory Molecules
Funder
National Health and Medical Research Council
Funding Amount
$729,414.00
Summary
The purpose of this work is to identify how a select population of cells (T regulatory cells) function to prevent or dampen down the sometimes-harmful effects of the immune system. Understanding how these cells function may have broad implications for general immune regulation.
In Vivo Real-time Tracking Of “color-coded” Supercharged Mesenchymal Stem Cells And T Cells In Allograft Rejection
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Growing specialized adult stem cells (MSC) in the presence of a unique immune signaling protein (IL-17) has generated a “supercharged” stem cell with superior abilities to dampen immune responses in cell and organ transplant patients. The use of these MSC in transplant patients may significantly reduce the dose of anti-rejection drugs required to prevent cell and organ rejection. By minimizing the dose of drugs, we aim to eliminate the risk of developing infections and cancer in these patients.