Self-assembled phases as effective and selective materials for analysis. This project aims to develop a suite of self-assembled amphiphilic molecules to form distinctive materials for analytical chemistry. The cost-effective, easy to prepare, selective and environmentally benign materials will be for non-volatile bioactive and chiral molecular targets that are commonly encountered every day or are difficult to study. The project will open a new research area and will further uplift the internati ....Self-assembled phases as effective and selective materials for analysis. This project aims to develop a suite of self-assembled amphiphilic molecules to form distinctive materials for analytical chemistry. The cost-effective, easy to prepare, selective and environmentally benign materials will be for non-volatile bioactive and chiral molecular targets that are commonly encountered every day or are difficult to study. The project will open a new research area and will further uplift the international standing of Australia in the field. The project will provide a high level of training and expertise for Australia-based chemists.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100035
Funder
Australian Research Council
Funding Amount
$4,958,927.00
Summary
ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, ....ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, providing the materials and inspiration for young researchers to apply novel hyphenated methods to complex environmental and industrial systems. This Centre will deliver fundamental developments in hyphenated technologies, new analytical capability, and applied outcomes across multiple end-user groups and interests. Read moreRead less
Solid-state light sources for bio-imaging and microfluidics. Solid state light sources are the light sources of the 21st century. This project will allow us to find new ways of bioimaging in living organisms applicable to diagnosing disease, and for microfluidic chip based portable instruments for on-site and point-of-care analysis in medical diagnostics, environmental monitoring, and manufacturing processes.
The Tasmanian Healthy Brain Project: A Longitudinal Intervention Study To Reduce The Risk Of Ageing-related Cognitive Decline And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$878,792.00
Summary
It has been proposed that engagement in purposeful complex mental stimulation provides protection against dementia. The Tasmanian Healthy Brain Project (THBP) is a unique, large-scale prospective trial that examines whether university-level study in older adult population reduces ageing-related cognitive decline and risk of dementia. This project will also examine how an individual’s genetic profile may influence the potential benefits of complex mental stimulation as well as risk of dementia.
Lectin based open tubular micro-reactors for probing protein-protein binding. This project seeks to develop non-invasive technology for the measurement and quantitation of lectin-carbohydrate binding events, in the first instance glycopeptides and glycoproteins. The goal is not only to provide accurate protein-protein association and dissociation constant data within the developed system, but to do so within an enclosed micro-fluidic environment, with the added advantages of also providing ‘trap ....Lectin based open tubular micro-reactors for probing protein-protein binding. This project seeks to develop non-invasive technology for the measurement and quantitation of lectin-carbohydrate binding events, in the first instance glycopeptides and glycoproteins. The goal is not only to provide accurate protein-protein association and dissociation constant data within the developed system, but to do so within an enclosed micro-fluidic environment, with the added advantages of also providing ‘trap and release’ extraction capabilities, and being easily coupled to both chromatographic and mass spectrometry systems. Read moreRead less
Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encodi ....Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encoding and retrieval processes, the model can assess how changes in different sources of interference modulate performance through the trajectory of early development. Hierarchical Bayesian estimation aims to enable a simultaneous account of multiple tasks and support future deployment in applied contexts.Read moreRead less
A high speed, high fidelity 3D printer for fabricating microfluidic devices. This project aims to develop a novel 3D printer offering the highest resolution available and fastest printing speed for the single-step manufacturing of complex microfluidic devices. New resins developed to exploit the inert liquid interface layer printing approach will provide unprecedented capability to create micron sized channels interconnected in 3D space and fabricate Lab-on-a-Chip systems that cannot be generate ....A high speed, high fidelity 3D printer for fabricating microfluidic devices. This project aims to develop a novel 3D printer offering the highest resolution available and fastest printing speed for the single-step manufacturing of complex microfluidic devices. New resins developed to exploit the inert liquid interface layer printing approach will provide unprecedented capability to create micron sized channels interconnected in 3D space and fabricate Lab-on-a-Chip systems that cannot be generated by any current fabrication approach. This novel high speed, high fidelity 3D printer and the new resins to be developed are expected to lead to more effective manufacturing approaches for portable chemical devices and to promote complex chemical analysis into the knowledge immediacy culture of today.Read moreRead less
Intracortical inhibition evaluated by paired-pulse TMS during choice and simple reaction time tasks. The research will investigate the neurophysiological processes responsible for the selection and initiation of movement in response to an external stimulus. Slowness in the initiation and execution of movement is a common feature of 'neurological aging', neurodegenerative disease, and brain injury. Understanding the brain mechanisms involved in response selection and movement initiation will pro ....Intracortical inhibition evaluated by paired-pulse TMS during choice and simple reaction time tasks. The research will investigate the neurophysiological processes responsible for the selection and initiation of movement in response to an external stimulus. Slowness in the initiation and execution of movement is a common feature of 'neurological aging', neurodegenerative disease, and brain injury. Understanding the brain mechanisms involved in response selection and movement initiation will provide information for the development of specific intervention techniques to improve motor function in these groups.Read moreRead less
The role of the Supplementary Motor Area in time processing. The neural bases of timing mechanisms (0.1-100s range) are the subject of much debate. We hypothesise that the Supplementary Motor Area (SMA), a major cortical structure involving important dopaminergic pathways, subtends duration encoding, in the way depicted by the 'accumulator model'. Using transcranial magnetic stimulation (TMS) over the SMA, we will test healthy subjects in motor and perceptual timing tasks, compared to Parkinson' ....The role of the Supplementary Motor Area in time processing. The neural bases of timing mechanisms (0.1-100s range) are the subject of much debate. We hypothesise that the Supplementary Motor Area (SMA), a major cortical structure involving important dopaminergic pathways, subtends duration encoding, in the way depicted by the 'accumulator model'. Using transcranial magnetic stimulation (TMS) over the SMA, we will test healthy subjects in motor and perceptual timing tasks, compared to Parkinson's disease patients whose timing performance is impaired due to dopaminergic dysfunction. We expect TMS inhibitory effects to induce predictable performance trends, providing support for the accumulator model and the key role of the SMA in timing.Read moreRead less
Neural correlates of performance trade-offs and interference in dual-task performance. Our daily lives are characterised by our ability to produce and sustain a wide range of different movement patterns and to deliberately change patterns as the situation demands. In this project we seek to understand the relationship between brain processes, attentional demands, and the control and learning of coordinated behaviour. A further aim will be to examine how this relationship may be altered as a re ....Neural correlates of performance trade-offs and interference in dual-task performance. Our daily lives are characterised by our ability to produce and sustain a wide range of different movement patterns and to deliberately change patterns as the situation demands. In this project we seek to understand the relationship between brain processes, attentional demands, and the control and learning of coordinated behaviour. A further aim will be to examine how this relationship may be altered as a result of aging, degenerative disease, or brain damage. This research will provide a foundation upon which rehabilitation strategies can be developed for the movement impaired.Read moreRead less