Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and ....Tuneable “Nano-Shearing”: An Innovative Mechanism for the Accurate and Specific Capture of Cells and Molecules. Recent investigations have discovered a tuneable electro-hydrodynamic force which drives lateral fluid motion within a few nanometers of an electrode surface. Because the magnitude of this fluid shear force can be tuned externally (for example, via the application of an AC electric field), it provides a new capability to physically displace weakly (non-specifically) bound cellular and molecular analytes. By performing research to further understand and develop this tuneable effect, this project aims to build and test a new platform technology to enable highly efficient capture and specific detection of low concentration pathogenic molecules and circulating tumour cells (CTCs).Read moreRead less
Noncanonical epitope recognition by CD8+ T lymphocytes. This proposed research program will provide significant fundamental insight in the areas of immunology and vaccine design. Vaccines for many diseases remain elusive, and this project aims to improve our understanding of the precise regions within pathogens that are the targets for the killer T cells of the immune system. These regions, called epitopes, are likely to be key ingredients in many future vaccines. Although immunologists have gat ....Noncanonical epitope recognition by CD8+ T lymphocytes. This proposed research program will provide significant fundamental insight in the areas of immunology and vaccine design. Vaccines for many diseases remain elusive, and this project aims to improve our understanding of the precise regions within pathogens that are the targets for the killer T cells of the immune system. These regions, called epitopes, are likely to be key ingredients in many future vaccines. Although immunologists have gathered much information about such epitopes, recent studies have shown that some unexpected regions of pathogens are targets for killer T cells. This project will break new ground by utilising unbiased procedures to assess the relative contribution of these noncanonical epitopes to immunity.Read moreRead less
The Control of Memory Access. The topic of control processes in memory access is central to most of the big questions about human memory such as; why we forget, what produces spectacular and tragic memory failures (e.g.,lighting a match to check the level of petrol in a tank) and the role of context in familiarity and recollection. Because of the centrality of the problems addressed there will be many applications for the results. The long term results will include better models for human ope ....The Control of Memory Access. The topic of control processes in memory access is central to most of the big questions about human memory such as; why we forget, what produces spectacular and tragic memory failures (e.g.,lighting a match to check the level of petrol in a tank) and the role of context in familiarity and recollection. Because of the centrality of the problems addressed there will be many applications for the results. The long term results will include better models for human operators which can be used in both civilian (e.g., air traffic control) and military applications. Other areas of application will include how we measure memory impairment, why we make errors in industrial settings, and the nature of memory deficits as we age. Read moreRead less
Using Converging Methodologies to Understand Episodic and Semantic Memory. The use of four converging methodologies and a new objective measure of implicit/explicit memory will produce a more fundamental understanding of the relationship between pre-existing and episodic memories. The results will be relevant to the current debate over repressed and false memories. The research will also provide more stringent tests of techniques and methods that are having a large impact in applied research ....Using Converging Methodologies to Understand Episodic and Semantic Memory. The use of four converging methodologies and a new objective measure of implicit/explicit memory will produce a more fundamental understanding of the relationship between pre-existing and episodic memories. The results will be relevant to the current debate over repressed and false memories. The research will also provide more stringent tests of techniques and methods that are having a large impact in applied research on aging, drug states etc.Read moreRead less
Understanding and controlling bioavailability: passive dosing of persistent organic pollutants into recombinant cell bioassays. Bioassays with mammalian cell lines may replace animal testing in chemical risk assessment if issues with limited sensitivity can be overcome for very hydrophobic chemicals such as polychlorinated dibenzodioxins. The project will solve this problem by developing a polymer-release dosing technique that assures defined and constant exposure.
Disinfection by-products formed during drinking water treatment: reducing the unknowns is managing risk. Disinfection of drinking water is a successful measure to reduce water-borne diseases and protect health. However, epidemiological evidence links bladder cancer to disinfection by-products formed during drinking water treatment. Despite decades of research the causative agents remain to be identified. To fill this knowledge gap, this project will quantify the fraction of toxicity that cannot ....Disinfection by-products formed during drinking water treatment: reducing the unknowns is managing risk. Disinfection of drinking water is a successful measure to reduce water-borne diseases and protect health. However, epidemiological evidence links bladder cancer to disinfection by-products formed during drinking water treatment. Despite decades of research the causative agents remain to be identified. To fill this knowledge gap, this project will quantify the fraction of toxicity that cannot be explained by known chemicals in water samples treated with different disinfectants using a combination of chemical analysis and in-vitro bioassays. Samples with high unexplained effects will then be fractionated to isolate toxicologically relevant disinfection by-products, which will ultimately be identified with non-target chemical analysis.Read moreRead less
The many faces of threat: An investigation of animal, interpersonal and intergroup threat. Threat to personal safety can take a number of guises, a snake in the grass, an angry neighbour or, increasingly often in our modern world, a stranger who looks different. The present project will investigate the manner in which we respond to these threats, whether these responses can be modulated and what determines the threatening nature of an event. A better understanding of how we react to real or p ....The many faces of threat: An investigation of animal, interpersonal and intergroup threat. Threat to personal safety can take a number of guises, a snake in the grass, an angry neighbour or, increasingly often in our modern world, a stranger who looks different. The present project will investigate the manner in which we respond to these threats, whether these responses can be modulated and what determines the threatening nature of an event. A better understanding of how we react to real or perceived threats, in particular those involving other humans, will aid our understanding of human behaviour in an ever faster changing environment, both in our region and more broadly. Read moreRead less
The recognition of human body shape in infancy. Newborn infants have expectations about human faces and it is hypothesised that this early knowledge allows them to identify and begin to engage with other humans. While faces are central to identification of and communication with others, human bodies are also highly informative and expressive, yet to date there is almost no research on infants? expectations about human bodies. This proposal details six studies that will systematically explore a ....The recognition of human body shape in infancy. Newborn infants have expectations about human faces and it is hypothesised that this early knowledge allows them to identify and begin to engage with other humans. While faces are central to identification of and communication with others, human bodies are also highly informative and expressive, yet to date there is almost no research on infants? expectations about human bodies. This proposal details six studies that will systematically explore and document the development of infants? expectations about human bodies, and will further test the theory that infants? earliest social interactions are dependent upon representations of the human face and body.Read moreRead less
Maternal input and theory of mind development in infancy and early childhood. When parents talk to their children, they influence their development both by what they say and how they say it. Building on previous ARC-funded work, this project will examine how and to what extent parents converse about mental states with their children, as well as investigating the influence of such parental talk on the child's socio-cognitive understanding of others' minds and emotions. Results promise to supply ....Maternal input and theory of mind development in infancy and early childhood. When parents talk to their children, they influence their development both by what they say and how they say it. Building on previous ARC-funded work, this project will examine how and to what extent parents converse about mental states with their children, as well as investigating the influence of such parental talk on the child's socio-cognitive understanding of others' minds and emotions. Results promise to supply important insights into the complex interaction of biology and socialisation in normal development, and will also serve as a foundation for future interventions to help children who are at risk for social problems.Read moreRead less
Social Influences on Five Key Steps in Understanding Mind for Children with Autism, Deafness or Typical Development. Via new knowledge on five crucial steps in the growth of social understanding, our findings will serve the ARC's Research Priority #2 to promote good health and a healthy start in life. We will discover what kinds of parenting, social interaction and conversation foster optimal progress through the steps for typical children, and how the delays discovered in our earlier research ....Social Influences on Five Key Steps in Understanding Mind for Children with Autism, Deafness or Typical Development. Via new knowledge on five crucial steps in the growth of social understanding, our findings will serve the ARC's Research Priority #2 to promote good health and a healthy start in life. We will discover what kinds of parenting, social interaction and conversation foster optimal progress through the steps for typical children, and how the delays discovered in our earlier research among those with autism or deafness can be offset or overcome. Also, Australia's position as a world leader in scientific studies of child social cognition will be further strengthened by our methodological and theoretical contributions.
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