Modeling Human Actin Related Protein 2/3 Complex Subunit 1B (ARPC1B) Deficiency In Mice
Funder
National Health and Medical Research Council
Funding Amount
$755,005.00
Summary
The actin cytoskeleton forms the structure that not only keeps cells in their normal shape but is also essential for the movement of cells and for interaction between cells. We have recently identified the first patients with an immunodeficiency caused by a defect in a gene called ARPC1B, which plays a crucial role in the regulation of actin. Through the investigation of novel mouse models we will elucidate the pathomechanism underlying the disease of these patients.
The Tasmanian Healthy Brain Project: A Longitudinal Intervention Study To Reduce The Risk Of Ageing-related Cognitive Decline And Dementia
Funder
National Health and Medical Research Council
Funding Amount
$878,792.00
Summary
It has been proposed that engagement in purposeful complex mental stimulation provides protection against dementia. The Tasmanian Healthy Brain Project (THBP) is a unique, large-scale prospective trial that examines whether university-level study in older adult population reduces ageing-related cognitive decline and risk of dementia. This project will also examine how an individual’s genetic profile may influence the potential benefits of complex mental stimulation as well as risk of dementia.
Individual Differences in Orientations to Risk and Uncertainty. The main goal of this research project is to extend and integrate three individual-differences approaches to predicting and explaining human judgement and decision making (JDM) and risk-taking behaviours (RTB) under uncertainty: Cognitive-capacity, preferences and dispositions, and dual cognitive process approaches. It will achieve this by studying the joint impact of cognitive style, capacities, and RTB/JDM dispositions on performa ....Individual Differences in Orientations to Risk and Uncertainty. The main goal of this research project is to extend and integrate three individual-differences approaches to predicting and explaining human judgement and decision making (JDM) and risk-taking behaviours (RTB) under uncertainty: Cognitive-capacity, preferences and dispositions, and dual cognitive process approaches. It will achieve this by studying the joint impact of cognitive style, capacities, and RTB/JDM dispositions on performance in appropriate JDM tasks. JDM and RTB are at the root of managing uncertainty, human adaptiveness and rationality. This project will also extend our knowledge of gender differences in JDM and RTB, and lay foundations for systematic cross-cultural studies on this topic.Read moreRead less
Programming Paradigms, Tools and Algorithms for Electronic Structure Calculations on Clusters of Non-Uniform Memory Access Parallel Processors. In recent years Australian academia has invested heavily in high performance computing systems. A significant fraction of these resources are devoted to performing computational chemistry studies, such as those used in drug design. This project links Australian researchers with the company responsible for a particularly widely used computational chemistr ....Programming Paradigms, Tools and Algorithms for Electronic Structure Calculations on Clusters of Non-Uniform Memory Access Parallel Processors. In recent years Australian academia has invested heavily in high performance computing systems. A significant fraction of these resources are devoted to performing computational chemistry studies, such as those used in drug design. This project links Australian researchers with the company responsible for a particularly widely used computational chemistry application package, and also with a major international computer company. Our aim is to substantially improve the performance of this code on cluster based compute systems. This, as well as our generic performance evaluation tools, would be of substantial benefit to the Australian research community. The project will forge links with researchers in Singapore, Japan and the USA.Read moreRead less
Face recognition: Properties and origins of whole-face processing. Humans identify other individuals almost entirely by their faces. Correspondingly, research has demonstrated a "special" style of cognitive processing that is unique to faces (at least in ordinary adults). The present project will address two major theoretical issues: (1) the exact nature of the special processing for faces, and (2) the extent to which it is innate, or learned. New progress in understanding these issues will be m ....Face recognition: Properties and origins of whole-face processing. Humans identify other individuals almost entirely by their faces. Correspondingly, research has demonstrated a "special" style of cognitive processing that is unique to faces (at least in ordinary adults). The present project will address two major theoretical issues: (1) the exact nature of the special processing for faces, and (2) the extent to which it is innate, or learned. New progress in understanding these issues will be made using a series of novel experimental techniques. These techniques isolate the specific contribution of the face recognition system, independent of contributions from object recognition, and from early visual processing.Read moreRead less
Special cognitive processing for faces: Expertise effects, and links to neural mechanisms. Humans identify other individuals primarily by their faces. Evidence from cognitive psychology indicates a special 'whole-face' (as opposed to part-based) style of processing for upright faces. This project will provide new insights into two long-standing issues about the origin of special face processing: (1) whether it derives from generic expert recognition processes or has some face-specific innate co ....Special cognitive processing for faces: Expertise effects, and links to neural mechanisms. Humans identify other individuals primarily by their faces. Evidence from cognitive psychology indicates a special 'whole-face' (as opposed to part-based) style of processing for upright faces. This project will provide new insights into two long-standing issues about the origin of special face processing: (1) whether it derives from generic expert recognition processes or has some face-specific innate component; and (2) the extent to which it can be distinguished from part-based processing at the neural level using both functional brain imaging (fMRI) and adaptation to distorted faces.Read moreRead less
Programming Paradigms, Tools and Algorithms for the Spectral Solution of the Electronic Schroedinger Equation on Non-Uniform Memory Parallel Processors. We propose to develop software tools and methods that are appropriate for current and future generations of large scale shared memory computer systems. Our purpose is to enable a more productive utilization of these architectures for scientific computation. We will focus on algorithms for solving differential equations appropriate to quantum che ....Programming Paradigms, Tools and Algorithms for the Spectral Solution of the Electronic Schroedinger Equation on Non-Uniform Memory Parallel Processors. We propose to develop software tools and methods that are appropriate for current and future generations of large scale shared memory computer systems. Our purpose is to enable a more productive utilization of these architectures for scientific computation. We will focus on algorithms for solving differential equations appropriate to quantum chemistry. In particular an exciting new class of methods whose computational cost scales linearly with system size. Our goal is to develop scalable parallel implementations of these methods. If realized this will revolutionize computation, enabling first principles calculations on truly nanoscale systems, such as enzymes and molecular electronic devices.Read moreRead less
Language processing in children with high functioning autism: Evidence from eye tracking. The language abilities in people with autism predict their response to intervention and their cognitive outcome. Young children with autism with poor language abilities are severely disadvantaged. Yet we understand little about what impedes their language development and their interpretation of what others say. The research findings will make a significant contribution by enriching our understanding of why ....Language processing in children with high functioning autism: Evidence from eye tracking. The language abilities in people with autism predict their response to intervention and their cognitive outcome. Young children with autism with poor language abilities are severely disadvantaged. Yet we understand little about what impedes their language development and their interpretation of what others say. The research findings will make a significant contribution by enriching our understanding of why and how comprehension may go astray, as well as helping us to identify subgroups within the autism population.Read moreRead less
Trauma memory and narrative structure in post-traumatic distress. The project enhances understanding of factors that maintain enduring distress and disability following traumatic experiences which have major social and financial costs to individuals, communities and to the nation. Better knowledge of these factors is central to improving early detection and refining prevention and early intervention for individuals and to help understand how communities can better manage their response to sever ....Trauma memory and narrative structure in post-traumatic distress. The project enhances understanding of factors that maintain enduring distress and disability following traumatic experiences which have major social and financial costs to individuals, communities and to the nation. Better knowledge of these factors is central to improving early detection and refining prevention and early intervention for individuals and to help understand how communities can better manage their response to severe traumatic events. The results may lead to significant refinements to efficacious psychological treatments involving exposure to emotional memories. The project's innovative approach to studying autobiographical memories will enhance Australia's internationally competitiveness in a key area within psychology.Read moreRead less
Dynamic Cooperative Performance Optimizations. This project seeks to improve the reliability, security, and
performance of modern software systems. Security is a problem of such
scale that outbreaks of computer viruses etc. headline in major
financial newspapers. We approach the problem by addressing the key
performance problems that hold back the programming languagues widely
used for secure and reliable systems. By improving the reliability,
security and performance of computer system ....Dynamic Cooperative Performance Optimizations. This project seeks to improve the reliability, security, and
performance of modern software systems. Security is a problem of such
scale that outbreaks of computer viruses etc. headline in major
financial newspapers. We approach the problem by addressing the key
performance problems that hold back the programming languagues widely
used for secure and reliable systems. By improving the reliability,
security and performance of computer systems, this project will help
alleviate the millions of hours and dollars lost to inadvertent errors
and malicious software attacks. The project will give Australia an
international presence in a research area of great academic and
commercial importance.Read moreRead less