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Dissecting Human B-cell Function: From Primary Immunodeficiencies To Chronic Inflammatory Disease
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
Despite knowing a lot about immunity in a mice, functional analysis of the human immune system has been a major challenge. I will study defects of immune cells in humans with gene mutations that cause an antibody deficiency. With new insights from these unique clinical samples, I will functionally dissect human immune responses, directly translate these to chronic inflammatory disease, and provide implications for future vaccine development and cancer treatment.
This Program Grant brings together a world-leading team of experts to elucidate mechanisms that protect most people from infection by making antibodies, and their failure caused by genes or infections like influenza or HIV. The team will determine mechanisms that protect most people from making antibodies against normal parts of our body, whose failure causes numerous autoimmune diseases including rheumatoid arthritis. The team will develop ways to engineer better antibodies.
Sytemic And Mucosal Functional Antibodies In Protection Against HIV
Funder
National Health and Medical Research Council
Funding Amount
$559,501.00
Summary
Only one human HIV vaccine has shown any level of protective efficacy. However the mechanisms behind how this vaccine was protective are still not fully understood. Additionally, HIV is primarily transmitted through mucosal sites, however very little is know about vaccine immune responses at these sites. Thus this proposal aims to further define the mechanisms of antibody protection against HIV at both systemic and mucosal locations, in order to guide future HIV vaccine design efforts.
Importance Of Functional Antibodies Against Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Antibodies are highly functional proteins capable of recognizing infectious disease pathogens and instructing surrounding immune cells to attack them. This project aims to identify specific antibody targets on HIV and Mycobacterium Tuberculosis associated with protection/control of disease and to understand the mechanisms behind the most functional antibodies. Ultimately, these studies will guide the development of future vaccines and therapies against these deadly pathogens.
Innate Immune Effector Recruiting Potential Of HIV-1 Human Vaccine Induced Antibodies
Funder
National Health and Medical Research Council
Funding Amount
$333,018.00
Summary
A HIV vaccine is urgently needed. A recent human HIV vaccine trial has indicated that Antibody Dependent Cellular Cyotoxicity (ADCC) may be protective. Understanding the role of ADCC HIV-specific antibodies in the context of vaccination has now become one of the most critical questions in HIV vaccine research today. This research aims to comprehensively study ADCC in samples from various HIV Vaccine trials to develop improved vaccine strategies to prevent the devastating consequences of HIV/AIDS ....A HIV vaccine is urgently needed. A recent human HIV vaccine trial has indicated that Antibody Dependent Cellular Cyotoxicity (ADCC) may be protective. Understanding the role of ADCC HIV-specific antibodies in the context of vaccination has now become one of the most critical questions in HIV vaccine research today. This research aims to comprehensively study ADCC in samples from various HIV Vaccine trials to develop improved vaccine strategies to prevent the devastating consequences of HIV/AIDS.Read moreRead less
Mechanisms Controlling Antibody Production By Modulating B Cell Antigen Receptor Signalling
Funder
National Health and Medical Research Council
Funding Amount
$536,628.00
Summary
This project will analyse mechanisms that regulate antibody production in health and disease. In health, antibodies are normally made exclusively against infectious agents, providing long-lasting immunity. Unknown errors in the control of antibody production result in autoimmune diseases such as systemic lupus or rheumatoid arthritis, where antibodies are made against parts of our own bodies, or result in allergies where antibodies are made against innocuous elements of our environment, or resul ....This project will analyse mechanisms that regulate antibody production in health and disease. In health, antibodies are normally made exclusively against infectious agents, providing long-lasting immunity. Unknown errors in the control of antibody production result in autoimmune diseases such as systemic lupus or rheumatoid arthritis, where antibodies are made against parts of our own bodies, or result in allergies where antibodies are made against innocuous elements of our environment, or result in uncontrolled B cell accumulation in lymphoma, leukemia and myeloma. In order to develop rational, specific methods for treating these diseases, it is necessary to identify and understand the biochemical mechanisms that normally control antibody formation against infectious agents, self components, and innocuous environmental agents. The project focuses on defining the biochemical mechanisms by which the antibody-forming cells, B lymphocytes, sense infectious, innocuous, or self components. These cells carry specific receptors that bind these components and transmit signals into the B lymphocyte. The research will determine how different types of signal are transmitted by the receptor so that, normally, large amounts of antibody are made against infectious agents but very little antibody is made against self components, and that B cell accumulation is tightly limited. By identifying how the types of signals are changed, the results of this project will reveal control mechanisms that may be altered in autoimmunity, allergy, immune deficiency, or lymphoma, and that may be able to be used as drug targets to cure these diseases.Read moreRead less