Histone H3.3-dependent transcriptional control and B cell differentiation. This project aims to investigate the fundamental way cells assemble transcriptional machinery to turn on genes and retain transcriptional memory. This project expects to generate new knowledge in the areas of both chromatin biology and immunology, using interdisciplinary approaches. Expected outcomes of this project include an enhanced capacity, through institutional and international collaborations, to determine whether ....Histone H3.3-dependent transcriptional control and B cell differentiation. This project aims to investigate the fundamental way cells assemble transcriptional machinery to turn on genes and retain transcriptional memory. This project expects to generate new knowledge in the areas of both chromatin biology and immunology, using interdisciplinary approaches. Expected outcomes of this project include an enhanced capacity, through institutional and international collaborations, to determine whether the rapid transcription and function characteristic of immune memory in response to stimuli is due to histone H3 variant and its associated nuclear bodies. This should provide significant benefits, such as understanding epigenetic mechanisms that underlie transcription initiation and maintenance across many species.Read moreRead less
Epigenetic regulation of immune memory. Immune memory cells emerge from the dynamic and transient immune response to deliver two critical abilities: to produce rapid recall responses upon reinfection but also to persist for decades. This project aims to define how the polycomb repressive complexes regulate immune cell fate, by utilising cutting-edge cell and chromatin biology techniques coupled with bioinformatic pipelines. Expected outcomes of the proposed research include key insights into epi ....Epigenetic regulation of immune memory. Immune memory cells emerge from the dynamic and transient immune response to deliver two critical abilities: to produce rapid recall responses upon reinfection but also to persist for decades. This project aims to define how the polycomb repressive complexes regulate immune cell fate, by utilising cutting-edge cell and chromatin biology techniques coupled with bioinformatic pipelines. Expected outcomes of the proposed research include key insights into epigenetic programming required for immune cell differentiation and longevity. This should provide significant benefits such as knowledge creation that may lead to development of technology that reprograms cell behaviour, and contribution to Australian research recognition and capacity.Read moreRead less