The Role Of Novel G-Protein Coupled Receptors In Immunity And Inflammatory Diseases
Funder
National Health and Medical Research Council
Funding Amount
$69,684.00
Summary
Recent advances in molecular biology techniques have resulted in the identification of many novel GPCRs. Novel GPCRs expressed selectively on immune cells display a potential target for novel therapies for inflammatory diseases such as Asthma and Rheumatoid arthritis. This project aims to define the activity and significance of a novel group of GPCRs, the GPR40 family. Outcomes of this project will be further understanding of immune cell development and inflammatory disease development.
Understanding The Impact Of Social, Economic And Geographic Disadvantage On The Health Of Australians In Mid - Later Lif
Funder
National Health and Medical Research Council
Funding Amount
$1,943,571.00
Summary
This research will examine the ways in which social, economic and environmental factors contribute to the health of Australians in mid to later life. It will help identify ways in which policy and preventive programs can contribute to improving health in mid to later life particularly among disadvantaged Australians. We will explore in detail social, economic and environmental factors in 100,000 people aged 45 and over; this will be the largest study of its kind ever undertaken in Australia. We ....This research will examine the ways in which social, economic and environmental factors contribute to the health of Australians in mid to later life. It will help identify ways in which policy and preventive programs can contribute to improving health in mid to later life particularly among disadvantaged Australians. We will explore in detail social, economic and environmental factors in 100,000 people aged 45 and over; this will be the largest study of its kind ever undertaken in Australia. We will examine the relationship between these social, economic factors, and lifestyle factors such as smoking, physical activity, environmental and obesity. This will enable us to identify where programs and policies should be directed to most rapidly improve the health of disadvantaged Australians.Read moreRead less
The Interplay Between Viperin, Peroxisomes And The Cellular Innate Antiviral Response
Funder
National Health and Medical Research Council
Funding Amount
$556,127.00
Summary
Infection with a virus initiates a cellular antiviral response that attempts to limit viral replication, however how this response is regulated is not well understood. In this proposal we will investigate a cellular protein (viperin) that can regulate this process by interaction with peroxisomes to amplify the antiviral response. This work will provide possible targets for therapeutic manipulation of the innate immune response that will be applicable to a wide range of viral infections.
Disparities In Care And Outcome For People With Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$74,047.00
Summary
This thesis will investigate disparities in lung cancer care and outcomes, provide an overview of lung cancer disparities in NSW and seek to identify and assess an intervention to reduce lung cancer disparities. This will involve a systematic review of cancer disparity measures, empirical research to investigate patterns and predictors of disparity. Mixed methods will be used to investigate observed disparities and identify interventions to improve cancer care and outcomes in vulnerable groups.
Minimally invasive monitoring of sleep for disease management. Sleep, diet and exercise are the three pillars of wellbeing with poor sleep associated with medical issues such as obesity and congestive heart failure. This project will advance sleep analysis by researching new ways of monitoring that are highly accurate and convenient, enabling physicians to improve the monitoring of significant health issues.
The role of oxytocin in attachment patterns and socio-emotional development. The role of oxytocin in attachment patterns and socio-emotional development. This project aims to better understand how oxytocin mediates links between maternal sensitivity and attachment and child socio-emotional outcomes. The child's emotional health is the most powerful childhood predictor of adult life satisfaction, and evidence points to the pivotal role of the oxytocin system on mother-child interactions and attac ....The role of oxytocin in attachment patterns and socio-emotional development. The role of oxytocin in attachment patterns and socio-emotional development. This project aims to better understand how oxytocin mediates links between maternal sensitivity and attachment and child socio-emotional outcomes. The child's emotional health is the most powerful childhood predictor of adult life satisfaction, and evidence points to the pivotal role of the oxytocin system on mother-child interactions and attachment representations that affect children's socio-emotional development. As a longitudinal study of oxytocin function in mother-child dyads, it examines how genetic, epigenetic and parenting factors determine socio-emotional and temperamental outcomes.Read moreRead less
Deciphering How TCR Affinity Regulates CD4 T Cell Help In Immunity And Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$850,885.00
Summary
Immune responses require the coordinated interaction and cross-talk between two types of white blood cells known as CD4 and CD8 T cells. A dysregulated interaction between these cells could be the cause of autoimmune and persistent infections by pathogens leading to chronic diseases. The aim of this proposal is to provide a deeper understanding of CD4/CD8 T cell interactions to improve immune outcomes in many chronic diseases in which interaction between these two immune cells is critical.
Gene Expression Biomarkers Predict Severe Asthma Inflammatory Phenotype, Activation Mechanisms And Treatment Response
Funder
National Health and Medical Research Council
Funding Amount
$465,627.00
Summary
Asthma is now recognised to be made up of several disease variants or phenotypes, which are likely to have different underlying causes and mechanisms. We lack understanding of how to identify phenotypes of asthma and how they work, and this is delaying research that will lead to improvements in treatments and patient care. This is particularly important in people with severe disease. This grant will establish a gene test to identify asthma phenotype, and further understand mechanisms and treatme ....Asthma is now recognised to be made up of several disease variants or phenotypes, which are likely to have different underlying causes and mechanisms. We lack understanding of how to identify phenotypes of asthma and how they work, and this is delaying research that will lead to improvements in treatments and patient care. This is particularly important in people with severe disease. This grant will establish a gene test to identify asthma phenotype, and further understand mechanisms and treatment responses.Read moreRead less
Metal-air batteries with improved rate capability and safety for hearing applications. Hearing impairment affects on average 20% of the adult population in western society, with the impact being as high as 50% in older adults. Effective hearing devices require a significant amount of power, supplied by a battery, to support their function. Current batteries require very frequent replacement and represent a significant impediment to advances in the technology. This project will develop improved ....Metal-air batteries with improved rate capability and safety for hearing applications. Hearing impairment affects on average 20% of the adult population in western society, with the impact being as high as 50% in older adults. Effective hearing devices require a significant amount of power, supplied by a battery, to support their function. Current batteries require very frequent replacement and represent a significant impediment to advances in the technology. This project will develop improved energy and power density batteries which will lead to immediate implementation of more powerful signal processing algorithms, making hearing aids much more effective and appealing to the user. This, in turn, will improve recipient compliance and thus the quality of life for those with severe hearing impairment. Read moreRead less
Closing The Gap: Early Childhood Sustained Home Visiting For Families Of Aboriginal Infants In An Urban Community
Funder
National Health and Medical Research Council
Funding Amount
$2,244,402.00
Summary
The study aims to determine whether a sustained structured nurse home visiting (SSNVH) program is effective for Aboriginal families. In the context of increased government investment in home visiting programs for Indigenous children, this study will help to answer three critical questions: (1) Does SSNHV result in improved outcomes for Aboriginal infants? (2) Is SSNHV equally effective for Aboriginal and non-Aboriginal infants?(3) What are the issues in adaptation and implementation?