Understanding The Impact Of Social, Economic And Geographic Disadvantage On The Health Of Australians In Mid - Later Lif
Funder
National Health and Medical Research Council
Funding Amount
$1,943,571.00
Summary
This research will examine the ways in which social, economic and environmental factors contribute to the health of Australians in mid to later life. It will help identify ways in which policy and preventive programs can contribute to improving health in mid to later life particularly among disadvantaged Australians. We will explore in detail social, economic and environmental factors in 100,000 people aged 45 and over; this will be the largest study of its kind ever undertaken in Australia. We ....This research will examine the ways in which social, economic and environmental factors contribute to the health of Australians in mid to later life. It will help identify ways in which policy and preventive programs can contribute to improving health in mid to later life particularly among disadvantaged Australians. We will explore in detail social, economic and environmental factors in 100,000 people aged 45 and over; this will be the largest study of its kind ever undertaken in Australia. We will examine the relationship between these social, economic factors, and lifestyle factors such as smoking, physical activity, environmental and obesity. This will enable us to identify where programs and policies should be directed to most rapidly improve the health of disadvantaged Australians.Read moreRead less
The Role Of Duffy And PF4 In The Platelet Killing Of Malaria Parasites.
Funder
National Health and Medical Research Council
Funding Amount
$350,045.00
Summary
Platelets in the blood can kill the Plasmodium parasite, which lives inside red blood cells and causes malaria. Platelets bind parasite-infected red cells and release a molecule that is toxic to the parasite. This project will study why a red cell molecule called Duffy is also needed for this function of platelets. Most Africans carry a gene for Duffy that stops its expression in red cells, and may therefore be more susceptible to malaria because their platelets cannot kill the malaria parasite.
Founders and survivors: Australian lifecourses in historical context. This project will create one of the world's outstanding longitudinal studies of human health and resilience. It will contribute to the historical understanding of European migration, settler colonialism, forced labour and human health under stress, long-run family formation and falling fertility, household economy, and the social determinants of health. It will contribute to debate both nationally and internationally on the lo ....Founders and survivors: Australian lifecourses in historical context. This project will create one of the world's outstanding longitudinal studies of human health and resilience. It will contribute to the historical understanding of European migration, settler colonialism, forced labour and human health under stress, long-run family formation and falling fertility, household economy, and the social determinants of health. It will contribute to debate both nationally and internationally on the long-run effects of social and biomedical interventions and of investment in human capital. It will tell the grassroots history of the Australian penal and colonial experiments and it will form a scholarly coalition with the great community of family historians. Read moreRead less
Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
What is normal brain ageing? An investigation of changes in brain structure and cognition in mid-life. Pathological brain changes associated with cognitive decline later in life become detectable in the 40s and sometimes earlier, yet little is known about what constitute normal brain ageing in midlife. Using a number of neuroimaging techniques, this project will develop a detailed map of brain and cognitive ageing in middle-age and their predictors.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
The role of short tandem repeat DNA variation in the evolution of human psychological diversity. The proposed work addresses fundamental questions about human nature. It ties together the evolutionary processes that have shaped us as a species with the way our genes influence: our personalities, the way we think and how we behave. It introduces a novel approach to addressing questions about the role of genetics in human variation that will contribute substantially to the way we understand, perce ....The role of short tandem repeat DNA variation in the evolution of human psychological diversity. The proposed work addresses fundamental questions about human nature. It ties together the evolutionary processes that have shaped us as a species with the way our genes influence: our personalities, the way we think and how we behave. It introduces a novel approach to addressing questions about the role of genetics in human variation that will contribute substantially to the way we understand, perceive and manage important aspects of human diversity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100077
Funder
Australian Research Council
Funding Amount
$441,935.00
Summary
A geospatial toolkit to assess community risk to environmental change. This project seeks to strengthen our understanding of the role of environmental change in driving patterns of community risk, by building a spatially and temporally explicit model, and a risk index that will be designed with input from decision makers. This project expects to improve the implementation of geospatial tools for risk assessment using an innovative approach based on evidence and practice. Expected outcomes includ ....A geospatial toolkit to assess community risk to environmental change. This project seeks to strengthen our understanding of the role of environmental change in driving patterns of community risk, by building a spatially and temporally explicit model, and a risk index that will be designed with input from decision makers. This project expects to improve the implementation of geospatial tools for risk assessment using an innovative approach based on evidence and practice. Expected outcomes include increased and optimal implementation of geospatial data in Australian systems, and enhanced research capacity to proactively respond to environmental change.Read moreRead less
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Assessing Bone Quality and Health: Experimental imaging, structural characterisation, and mechanical modelling of bone in 3D. Age-related bone fractures due to osteoporosis impose a significant social and economic problem on our increasingly aging population. The assessment of bone quality is important in the diagnosis of age related bone fragility and for studying the efficacy of therapeutic intervens. In this proposal a unique interdisciplinary group with expertise in bone and mineral research ....Assessing Bone Quality and Health: Experimental imaging, structural characterisation, and mechanical modelling of bone in 3D. Age-related bone fractures due to osteoporosis impose a significant social and economic problem on our increasingly aging population. The assessment of bone quality is important in the diagnosis of age related bone fragility and for studying the efficacy of therapeutic intervens. In this proposal a unique interdisciplinary group with expertise in bone and mineral research, experimental 3D imaging and the characterisation and modelling of complex materials will tackle the problem of assessing bone quality and health. The proposed research will greatly improve our assessment of the mechanical competence of bone.Read moreRead less