Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
The role of short tandem repeat DNA variation in the evolution of human psychological diversity. The proposed work addresses fundamental questions about human nature. It ties together the evolutionary processes that have shaped us as a species with the way our genes influence: our personalities, the way we think and how we behave. It introduces a novel approach to addressing questions about the role of genetics in human variation that will contribute substantially to the way we understand, perce ....The role of short tandem repeat DNA variation in the evolution of human psychological diversity. The proposed work addresses fundamental questions about human nature. It ties together the evolutionary processes that have shaped us as a species with the way our genes influence: our personalities, the way we think and how we behave. It introduces a novel approach to addressing questions about the role of genetics in human variation that will contribute substantially to the way we understand, perceive and manage important aspects of human diversity.Read moreRead less
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Exploring Wellbeing Outcomes in the Aquatic and Recreation Industry. This project aims to investigate the impact on individual wellbeing through use of public aquatic and recreation centres in Australia. Through the use of mixed methods across multiple locations, the project expects to generate new knowledge on the effect on users of different management and service models for the provision of aquatic and recreational infrastructure. Expected outcomes include a quantifiable measure of social and ....Exploring Wellbeing Outcomes in the Aquatic and Recreation Industry. This project aims to investigate the impact on individual wellbeing through use of public aquatic and recreation centres in Australia. Through the use of mixed methods across multiple locations, the project expects to generate new knowledge on the effect on users of different management and service models for the provision of aquatic and recreational infrastructure. Expected outcomes include a quantifiable measure of social and emotional wellbeing that can be utilised by centre management and government. This will help assessment of best practice for maximising community wellbeing, and can guide investment decisions by state and local government.Read moreRead less
Early-Stage Medical Diagnostics by Plasmon-Mediated Gas Sensing. This project will investigate the use plasmonic absorption of light in metal nanostructures to activate the selective oxidation/reduction of a gas molecule on a semiconductor nanoparticle. This concept will be used with the aim of developing a sensing technique capable of measuring ultra-low concentrations (ppb) of breath markers for lung cancer detection. It is expected that porous sensing films of semiconductor and metal nanopart ....Early-Stage Medical Diagnostics by Plasmon-Mediated Gas Sensing. This project will investigate the use plasmonic absorption of light in metal nanostructures to activate the selective oxidation/reduction of a gas molecule on a semiconductor nanoparticle. This concept will be used with the aim of developing a sensing technique capable of measuring ultra-low concentrations (ppb) of breath markers for lung cancer detection. It is expected that porous sensing films of semiconductor and metal nanoparticles with well-defined light absorption properties will be fabricated. Superior selectivity will be achieved by matching the wavelength of the absorbed light with the required activation energy for oxidation/reduction. Successful outcomes will enable multi-analyte fingerprint identification by on-chip devices with applications ranging from portable medical diagnostics to national security.Read moreRead less
Inhibition Of Interferon-?/? Induction By Ross River Virus
Funder
National Health and Medical Research Council
Funding Amount
$589,664.00
Summary
Ross River virus is a mosquito-borne virus that causes arthritis in the joints of many people infected. This project will look at the early interactions of a virulent virus with the mammalian host that appear to enable the virus to replicate and spread in the host and thereby cause disease. These interactions are with the host interferon protein which the virus has developed the ability to inhibit. The effect of the invading virus on the host's interferon system, part of the immune system, will ....Ross River virus is a mosquito-borne virus that causes arthritis in the joints of many people infected. This project will look at the early interactions of a virulent virus with the mammalian host that appear to enable the virus to replicate and spread in the host and thereby cause disease. These interactions are with the host interferon protein which the virus has developed the ability to inhibit. The effect of the invading virus on the host's interferon system, part of the immune system, will be examined.Read moreRead less
Using multiple data sources to understand the opioid crisis in Australia . This project aims to improve the quality and integration of population-level data for monitoring the consumption of opioids, licit and illicit, in Queensland communities. The analysis of opioids in wastewater, integrated with opioid use information such as prescription and seizure statistics will vastly increase knowledge of consumption patterns of opioids. By analysing wastewater samples from 2011 and triangulating with ....Using multiple data sources to understand the opioid crisis in Australia . This project aims to improve the quality and integration of population-level data for monitoring the consumption of opioids, licit and illicit, in Queensland communities. The analysis of opioids in wastewater, integrated with opioid use information such as prescription and seizure statistics will vastly increase knowledge of consumption patterns of opioids. By analysing wastewater samples from 2011 and triangulating with other datasets, the expected outcomes include building capacity to estimate consumption of all opioids; detecting the misuse of licit and illicit opioids over time. Anticipated benefit is to provide objective evidence of opioid use patterns for decision makers and a framework for a national opioids monitoring program.Read moreRead less
New high aspect ratio roll-to-roll compatible ultraviolet polysiloxane nanoimprinting for low cost consumer, medical, and quantum devices. This project will explore materials and processes for the creation of low cost optical waveguide devices from hybrid polysiloxane materials with applications in consumer products, sensing, health monitoring and fundamental physics. The outcome will pave the way for new approaches to manufacturing opening up new markets for the technology.
Sleeping for Gold: The Influence of Sleep on the Sports Performance of Elite Athletes. The aim of this project is to improve the performance of Australia's elite athletes by enhancing the amount and quality of sleep that they obtain. This project will have three major benefits. First, successful role models will encourage more Australian children and adults to participate in sport. This is critical given that the incidence of obesity (a major risk factor for diabetes, cardiovascular disease and ....Sleeping for Gold: The Influence of Sleep on the Sports Performance of Elite Athletes. The aim of this project is to improve the performance of Australia's elite athletes by enhancing the amount and quality of sleep that they obtain. This project will have three major benefits. First, successful role models will encourage more Australian children and adults to participate in sport. This is critical given that the incidence of obesity (a major risk factor for diabetes, cardiovascular disease and some cancers) has doubled in Australia in the last 15 years as participation in sport has dropped. Second, the success of our elite athletes will provide a source of pride in our achievements as a nation. Third, this research will enable the Australian Institute of Sport to remain as an international leader in sports science research.Read moreRead less