Understanding The Impact Of Social, Economic And Geographic Disadvantage On The Health Of Australians In Mid - Later Lif
Funder
National Health and Medical Research Council
Funding Amount
$1,943,571.00
Summary
This research will examine the ways in which social, economic and environmental factors contribute to the health of Australians in mid to later life. It will help identify ways in which policy and preventive programs can contribute to improving health in mid to later life particularly among disadvantaged Australians. We will explore in detail social, economic and environmental factors in 100,000 people aged 45 and over; this will be the largest study of its kind ever undertaken in Australia. We ....This research will examine the ways in which social, economic and environmental factors contribute to the health of Australians in mid to later life. It will help identify ways in which policy and preventive programs can contribute to improving health in mid to later life particularly among disadvantaged Australians. We will explore in detail social, economic and environmental factors in 100,000 people aged 45 and over; this will be the largest study of its kind ever undertaken in Australia. We will examine the relationship between these social, economic factors, and lifestyle factors such as smoking, physical activity, environmental and obesity. This will enable us to identify where programs and policies should be directed to most rapidly improve the health of disadvantaged Australians.Read moreRead less
Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
The transition from secondary school to adulthood: Experiences and life outcomes for youth with an intellectual disability and their families. This project seeks to explore the challenges faced and outcomes achieved by students with an intellectual disability as they move from secondary school into adult life. The study will investigate the factors at an individual, educational, family, and societal level which positively and adversely affect outcomes for young people with an intellectual disab ....The transition from secondary school to adulthood: Experiences and life outcomes for youth with an intellectual disability and their families. This project seeks to explore the challenges faced and outcomes achieved by students with an intellectual disability as they move from secondary school into adult life. The study will investigate the factors at an individual, educational, family, and societal level which positively and adversely affect outcomes for young people with an intellectual disability and their families. Family impacts can include significant loss of income as parents may have to cease employment to care for their young adult who has limited employment or day placement options. Gaining the knowledge to minimise the disruption to family life, which often occurs at this time of transition, will lead to strengthening Australia's social and economic fabric.Read moreRead less
Analysing the protective role of platelets during malaria infection. Platelets protect the host during malarial infection. This project aims to study how platelets kill the malaria parasite by investigating the role of host molecules and their potential as novel antimalarial agents. The role of platelets in the pathogenesis of cerebral malaria syndrome will also be investigated.
Psychosocial and cognitive outcomes of residential relocation and retirement: The TRAnsitions In Later Life (TRAILL) project. Individual and social issues surrounding older adults' residential relocation and the transition to retirement are increasingly important in the context of Australia's ageing population. A better understanding of the factors that influence psychological well-being and intergenerational relationships during these major life transitions will play an important role in infor ....Psychosocial and cognitive outcomes of residential relocation and retirement: The TRAnsitions In Later Life (TRAILL) project. Individual and social issues surrounding older adults' residential relocation and the transition to retirement are increasingly important in the context of Australia's ageing population. A better understanding of the factors that influence psychological well-being and intergenerational relationships during these major life transitions will play an important role in informing government policy. This project aims to provide national and community benefits through informing policy related to housing and labour force participation, and by informing programs aimed at volunteer recruitment, retention and maximising the quality of the volunteer experience.Read moreRead less
Predictive analytics from at home telemonitoring of vital signs. Predictive analytics from at home telemonitoring of vital signs. This project aims to reduce unscheduled admissions to hospital, by developing statistical models of people’s health using longitudinal measurements of vital signs and questionnaires. Hospital costs are becoming unsustainable and will overwhelm state budgets within thirty years. Telehealth monitoring to manage chronic disease is becoming increasingly routine internatio ....Predictive analytics from at home telemonitoring of vital signs. Predictive analytics from at home telemonitoring of vital signs. This project aims to reduce unscheduled admissions to hospital, by developing statistical models of people’s health using longitudinal measurements of vital signs and questionnaires. Hospital costs are becoming unsustainable and will overwhelm state budgets within thirty years. Telehealth monitoring to manage chronic disease is becoming increasingly routine internationally and should reduce unnecessary hospital admissions and health service costs. To scale up telehealth services nationally, automated means of assessing changes in an individual health status are needed. This project’s automated risk assessment models are expected to identify exacerbations and orchestrate an optimal response from health services to reduce unscheduled admissions to hospital.Read moreRead less
Indigenous young people's resilience and wellbeing. This project aims to identify factors related to, and those which predict, the development of resilience and wellbeing in Indigenous youth. Resilience protects the social and emotional wellbeing of youth exposed to high levels of adversity, and reduces the likelihood of substance misuse, violence, and risky behaviour. This project will examine the development of resilience and wellbeing in Indigenous youth; compare Indigenous youth’s self-asses ....Indigenous young people's resilience and wellbeing. This project aims to identify factors related to, and those which predict, the development of resilience and wellbeing in Indigenous youth. Resilience protects the social and emotional wellbeing of youth exposed to high levels of adversity, and reduces the likelihood of substance misuse, violence, and risky behaviour. This project will examine the development of resilience and wellbeing in Indigenous youth; compare Indigenous youth’s self-assessment of their resilience and wellbeing between low and high risk cohorts; and study how community services develop youth wellbeing and resilience. The expected benefit of this research is a better understanding of connections among age, cultural identity, resilience, wellbeing and risky behaviours in Indigenous youth.Read moreRead less
Strengthening Indigenous adolescent mental health and wellbeing. Using Continous Quality Improvement processes, the research will collaboratively conceptualise, design, implement and evaluate the effectiveness of new approaches to mental health service delivery for adolescents aged 10-24 in three regionally diverse Indigenous Primary Healthcare Services. Expected research outcomes are a rigorous assessment of the impact and economic benefits of making quality improvements to mental health servic ....Strengthening Indigenous adolescent mental health and wellbeing. Using Continous Quality Improvement processes, the research will collaboratively conceptualise, design, implement and evaluate the effectiveness of new approaches to mental health service delivery for adolescents aged 10-24 in three regionally diverse Indigenous Primary Healthcare Services. Expected research outcomes are a rigorous assessment of the impact and economic benefits of making quality improvements to mental health services for Indigenous adolescents, Key benefits are 1) A locally-responsive adolescent mental health screening instrument; 2) Comprehensive evidence-informed service model in adolescent mental healthcare; 3) Best practice protocol for developing and managing adolescent mental health as a service delivery stream. Read moreRead less