The role of a novel protein, interferon epsilon, in reproductive tract immunity. This project aims to develop a world-first description of a new protein that has a protective role against female reproductive tract infections. This unique protein, called interferon epsilon, was discovered in our laboratory. This project will facilitate development of new therapeutic approaches of benefit in diseases such as Chlamydia and Herpes Simplex Virus.
The role of the other in self-regulation: Who, when, where, how, and why. We assume that some individuals, because of the role they have (e.g., parents), are significant others. Moreover, we assume that significant others influence our emotions, motivation, and behaviour. These assumptions have not been systematically tested using a self-regulatory framework. Also no coherent model, detailing how and why individuals come to be significant and the mechanisms by which they have an influence, ha ....The role of the other in self-regulation: Who, when, where, how, and why. We assume that some individuals, because of the role they have (e.g., parents), are significant others. Moreover, we assume that significant others influence our emotions, motivation, and behaviour. These assumptions have not been systematically tested using a self-regulatory framework. Also no coherent model, detailing how and why individuals come to be significant and the mechanisms by which they have an influence, has been proposed. We present a theoretical model to be tested in a sequence of 10 studies. The results will provide understanding of the role of significant others that will have applications in clinical settings and in organisational contexts.Read moreRead less
Transport and innate immune properties of DNA in bacterial nano-sized vesicles. All types of living organisms release nano-sized membrane vesicles or “blebs” which they use for intercellular communication and transport of molecules. This project will determine how bacteria package DNA within these vesicles, how this DNA is transported into host cells and how it triggers immune responses in these cells.
Socioeconomic status and health in Australia: An econometric investigation into causality and pathways. This project aims to provide new policy-relevant research focusing on the role of socioeconomic status (SES) in determining health outcomes for children and adults in Australia, and in reducing health-related inequalities. This project will use high-quality Australian longitudinal data and the most advanced econometric models to provide new insights into the pathways underlying the SES gradien ....Socioeconomic status and health in Australia: An econometric investigation into causality and pathways. This project aims to provide new policy-relevant research focusing on the role of socioeconomic status (SES) in determining health outcomes for children and adults in Australia, and in reducing health-related inequalities. This project will use high-quality Australian longitudinal data and the most advanced econometric models to provide new insights into the pathways underlying the SES gradient. The project will also use similar data for Britain as a valuable comparison point. The research will contribute to a better understanding of health outcomes relating to a healthy start to life and strengthening Australia's social and economic fabric.Read moreRead less
The structure and content of self-knowledge: When and how are implicit and explicit measures related and what do they tell us? Research has found clear links between individuals' beliefs about themselves and emotion, motivation, and behaviour. These beliefs also play a role in the development of and recovery from psychological illness. However, understanding has been limited by the use of explicit measures, which rely on our ability to 'know' everything about ourselves, and our willingness to di ....The structure and content of self-knowledge: When and how are implicit and explicit measures related and what do they tell us? Research has found clear links between individuals' beliefs about themselves and emotion, motivation, and behaviour. These beliefs also play a role in the development of and recovery from psychological illness. However, understanding has been limited by the use of explicit measures, which rely on our ability to 'know' everything about ourselves, and our willingness to disclose. We investigate how explicitly and implicitly measured self-knowledge affect emotion, motivation, and behaviour. As a result, we redress a major criticism of this research, and facilitate a greater understanding of the role of self-knowledge, including aspects that we are not able to articulate, in psychological well-being.Read moreRead less
Founders and survivors: Australian lifecourses in historical context. This project will create one of the world's outstanding longitudinal studies of human health and resilience. It will contribute to the historical understanding of European migration, settler colonialism, forced labour and human health under stress, long-run family formation and falling fertility, household economy, and the social determinants of health. It will contribute to debate both nationally and internationally on the lo ....Founders and survivors: Australian lifecourses in historical context. This project will create one of the world's outstanding longitudinal studies of human health and resilience. It will contribute to the historical understanding of European migration, settler colonialism, forced labour and human health under stress, long-run family formation and falling fertility, household economy, and the social determinants of health. It will contribute to debate both nationally and internationally on the long-run effects of social and biomedical interventions and of investment in human capital. It will tell the grassroots history of the Australian penal and colonial experiments and it will form a scholarly coalition with the great community of family historians. Read moreRead less
Working at the margin: the consequences of non-standard employment. This project plans to use survey data tracking Australians through time to examine the impacts of non-standard employment on labour market outcomes and on their health and wellbeing. Around 40 per cent of Australian workers are in non-standard forms of employment. Such jobs are typically associated with job insecurity, unpredictable working hours, and limited opportunities for career progression, which can all negatively affect ....Working at the margin: the consequences of non-standard employment. This project plans to use survey data tracking Australians through time to examine the impacts of non-standard employment on labour market outcomes and on their health and wellbeing. Around 40 per cent of Australian workers are in non-standard forms of employment. Such jobs are typically associated with job insecurity, unpredictable working hours, and limited opportunities for career progression, which can all negatively affect worker wellbeing and long-term employment prospects. But such jobs can also serve as a crucial entry point into the labour market, and for some workers may be a better match with personal preferences. Project results may inform current debates about the need for greater or lesser regulation of employment arrangements.Read moreRead less
Non-intrusive human activity sensing with radio signals. This project aims to develop a theoretical framework for sensing and detecting human activities based on wireless radio signals. The framework advances the state-of-the-art by discovering the fundamental theory, and defining a set of principles to guide practical system design. The framework will be validated and its scientific merit demonstrated through building several applications such as contactless human activity detection and vital s ....Non-intrusive human activity sensing with radio signals. This project aims to develop a theoretical framework for sensing and detecting human activities based on wireless radio signals. The framework advances the state-of-the-art by discovering the fundamental theory, and defining a set of principles to guide practical system design. The framework will be validated and its scientific merit demonstrated through building several applications such as contactless human activity detection and vital signs monitoring. This should benefit existing hospital and clinical patient services and promote home-care and self-care services at nationwide.Read moreRead less
Intraepithelial lymphocyte development and function in the intestine. This study aims to better understand the homeostatic maintenance and essential repair processes in the intestine. This project will generate new knowledge of how immune cells of the intestine, known as intraepithelial lymphocytes (IELs), engage with intestinal epithelial cells, neurons and commensal microbes to promote homeostasis and repair. Expected outcomes of this project will be identification of new molecules for future ....Intraepithelial lymphocyte development and function in the intestine. This study aims to better understand the homeostatic maintenance and essential repair processes in the intestine. This project will generate new knowledge of how immune cells of the intestine, known as intraepithelial lymphocytes (IELs), engage with intestinal epithelial cells, neurons and commensal microbes to promote homeostasis and repair. Expected outcomes of this project will be identification of new molecules for future drug and vaccine development to improve gut health and vaccination in mammals. This should provide significant benefits to the Australian population and livestock industry through improved protection against cancer, intestinal infections and increased productivity. Read moreRead less
Work life after a diagnosis of breast, prostate and colorectal cancer: Major disruption or work as usual. Each year, over 40,000 working-age individuals (as well as their families and workplaces) are affected by a diagnosis of cancer. This novel and important study will, for the first time in Australia, identify the extent and effects of loss of skilled workers from the workforce because of a diagnosis of breast, prostate or colorectal cancer and will lead to the development of new interventions ....Work life after a diagnosis of breast, prostate and colorectal cancer: Major disruption or work as usual. Each year, over 40,000 working-age individuals (as well as their families and workplaces) are affected by a diagnosis of cancer. This novel and important study will, for the first time in Australia, identify the extent and effects of loss of skilled workers from the workforce because of a diagnosis of breast, prostate or colorectal cancer and will lead to the development of new interventions that help people to recover from cancer. This project is critical to help advance health and labour policies in Australia which currently faces an ageing population, global economic unrest and rising unemployment.Read moreRead less