Transport and innate immune properties of DNA in bacterial nano-sized vesicles. All types of living organisms release nano-sized membrane vesicles or “blebs” which they use for intercellular communication and transport of molecules. This project will determine how bacteria package DNA within these vesicles, how this DNA is transported into host cells and how it triggers immune responses in these cells.
Bereavement of suicide and sudden death. Losing someone to suicide can have devastating affects on the survivors left behind. The aims of the present study include the identification of the processes and impacts of bereavement on survivors in various age groups. It also aims to identify critical points during the bereavement and factors which exacerbate and moderate negative impacts. This has been previously neglected in suicide research in Australia and its findings will add a multi-dimensional ....Bereavement of suicide and sudden death. Losing someone to suicide can have devastating affects on the survivors left behind. The aims of the present study include the identification of the processes and impacts of bereavement on survivors in various age groups. It also aims to identify critical points during the bereavement and factors which exacerbate and moderate negative impacts. This has been previously neglected in suicide research in Australia and its findings will add a multi-dimensional aspect to postvention not currently understood. It is expected that findings will help develop guidelines to ensure more effective detection and intervention for survivors, as well as enhancing social support and personal resilience.Read moreRead less
Sterile inflammation as a determinant of adaptive immunity. When we injure ourselves, the site of injury becomes inflamed, which may help healing or cause trouble. This project aims to understand how the normal response to injury is controlled and why the process may sometimes go wrong.
The role of short tandem repeat DNA variation in the evolution of human psychological diversity. The proposed work addresses fundamental questions about human nature. It ties together the evolutionary processes that have shaped us as a species with the way our genes influence: our personalities, the way we think and how we behave. It introduces a novel approach to addressing questions about the role of genetics in human variation that will contribute substantially to the way we understand, perce ....The role of short tandem repeat DNA variation in the evolution of human psychological diversity. The proposed work addresses fundamental questions about human nature. It ties together the evolutionary processes that have shaped us as a species with the way our genes influence: our personalities, the way we think and how we behave. It introduces a novel approach to addressing questions about the role of genetics in human variation that will contribute substantially to the way we understand, perceive and manage important aspects of human diversity.Read moreRead less
Work life after a diagnosis of breast, prostate and colorectal cancer: Major disruption or work as usual. Each year, over 40,000 working-age individuals (as well as their families and workplaces) are affected by a diagnosis of cancer. This novel and important study will, for the first time in Australia, identify the extent and effects of loss of skilled workers from the workforce because of a diagnosis of breast, prostate or colorectal cancer and will lead to the development of new interventions ....Work life after a diagnosis of breast, prostate and colorectal cancer: Major disruption or work as usual. Each year, over 40,000 working-age individuals (as well as their families and workplaces) are affected by a diagnosis of cancer. This novel and important study will, for the first time in Australia, identify the extent and effects of loss of skilled workers from the workforce because of a diagnosis of breast, prostate or colorectal cancer and will lead to the development of new interventions that help people to recover from cancer. This project is critical to help advance health and labour policies in Australia which currently faces an ageing population, global economic unrest and rising unemployment.Read moreRead less
Social perception in late adulthood. Social perception refers broadly to the ability to decode and react appropriately to the social signals sent out by other people, and is a critical predictor of social competency and wellbeing. The aim of this project is to gain a clearer picture of when and why older adults experience social perceptual difficulties, as well as any consequences of these difficulties. A key prediction is that those older adults who have most difficulty with social perception w ....Social perception in late adulthood. Social perception refers broadly to the ability to decode and react appropriately to the social signals sent out by other people, and is a critical predictor of social competency and wellbeing. The aim of this project is to gain a clearer picture of when and why older adults experience social perceptual difficulties, as well as any consequences of these difficulties. A key prediction is that those older adults who have most difficulty with social perception will also have lowest wellbeing. Identifying which older adults are most likely to experience social perceptual difficulties, as well as which aspects of social perception are relatively intact, are expected to help to guide interventions on how to maintain wellbeing in old age.Read moreRead less
Histone deacetylase functions in immune cells. This project aims to define how an enzyme (a histone deacetylase) enables innate immune cells (macrophages) to respond to specific danger signals, such as those activating Toll-like Receptors. To identify processes that provide specificity to signal transduction pathways, this project will characterise protein targets and biological functions of a specific class IIa histone deacetylase in macrophages. This project expects to result in an understandi ....Histone deacetylase functions in immune cells. This project aims to define how an enzyme (a histone deacetylase) enables innate immune cells (macrophages) to respond to specific danger signals, such as those activating Toll-like Receptors. To identify processes that provide specificity to signal transduction pathways, this project will characterise protein targets and biological functions of a specific class IIa histone deacetylase in macrophages. This project expects to result in an understanding of histone deacetylases and protein deacetylation in immune cell responses which can be harnessed to manipulate cell functions for basic science and biotechnology uses.Read moreRead less
Early-Stage Medical Diagnostics by Plasmon-Mediated Gas Sensing. This project will investigate the use plasmonic absorption of light in metal nanostructures to activate the selective oxidation/reduction of a gas molecule on a semiconductor nanoparticle. This concept will be used with the aim of developing a sensing technique capable of measuring ultra-low concentrations (ppb) of breath markers for lung cancer detection. It is expected that porous sensing films of semiconductor and metal nanopart ....Early-Stage Medical Diagnostics by Plasmon-Mediated Gas Sensing. This project will investigate the use plasmonic absorption of light in metal nanostructures to activate the selective oxidation/reduction of a gas molecule on a semiconductor nanoparticle. This concept will be used with the aim of developing a sensing technique capable of measuring ultra-low concentrations (ppb) of breath markers for lung cancer detection. It is expected that porous sensing films of semiconductor and metal nanoparticles with well-defined light absorption properties will be fabricated. Superior selectivity will be achieved by matching the wavelength of the absorbed light with the required activation energy for oxidation/reduction. Successful outcomes will enable multi-analyte fingerprint identification by on-chip devices with applications ranging from portable medical diagnostics to national security.Read moreRead less
How parents manage climate anxiety: coping and hoping for the whole family. This project studies how Australian parents manage climate anxiety for themselves and their families. Using mixed-methods/mixed-media approaches, it examines whether an increase in climate disasters is accelerating the spread of collective anxiety amongst families, how parents manage this anxiety for their children and partners, and if there are associated mental health burdens and gendered inequities in this management. ....How parents manage climate anxiety: coping and hoping for the whole family. This project studies how Australian parents manage climate anxiety for themselves and their families. Using mixed-methods/mixed-media approaches, it examines whether an increase in climate disasters is accelerating the spread of collective anxiety amongst families, how parents manage this anxiety for their children and partners, and if there are associated mental health burdens and gendered inequities in this management. It also looks at climate anxiety management across generations and climate histories, drawing out pessimistic/optimistic narratives about the future to enable action, resilience, and hope. It will produce an evidence base and photo-voice/documentary resources to help parents and support organisations combat climate anxiety.Read moreRead less
Light scattering in complex mesoscale systems. The aim of the proposed project is to develop tested theoretic models of, and test applications of, the scattering of light in complex mesoscale systems. This will include: light scattering by biological cells, including optical cancer detection, remote sensing of cell populations, flow cytometry and optical tweezers; optically driven micromachines, and nano- and micro-structured materials. These applications are of considerable technological, socia ....Light scattering in complex mesoscale systems. The aim of the proposed project is to develop tested theoretic models of, and test applications of, the scattering of light in complex mesoscale systems. This will include: light scattering by biological cells, including optical cancer detection, remote sensing of cell populations, flow cytometry and optical tweezers; optically driven micromachines, and nano- and micro-structured materials. These applications are of considerable technological, social, and economic importance, and significant advances are possible. Methods developed during this project will allow accurate theoretical calculations to be performed where only inadequate approximations have previously been possible.Read moreRead less