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Targeting Vitamin-reactive T Cells For Enhanced Immunity
Funder
National Health and Medical Research Council
Funding Amount
$2,590,576.00
Summary
A specialised set of T cells called mucosal-associated invariant T (MAIT) cells react against bacteria and yeast, and reside at mucosal sites where the body's immune defences are often breached, e.g. respiratory tract and intestinal mucosa. This study seeks to define the molecular signals driving the function of MAIT cells, particularly during infections. This information may lead to methods tailored to manipulating MAIT cells therapeutically.
Improving The Diagnosis, Treatment And Prevention Of Infectious Diseases In Children
Funder
National Health and Medical Research Council
Funding Amount
$2,410,857.00
Summary
I am a clinician scientist whose research team bridges the gap between laboratory and clinical research to reduce the impact of childhood infectious diseases worldwide. The two main themes within my research program are: 1. Improving the diagnosis of childhood tuberculosis (TB) in resource-poor settings. 2. Understanding how BCG, the vaccine used to protect against TB, reduces other childhood illnesses, including non-TB infections, allergies, eczema and asthma.
The Role Of Mucosal-Associated Invariant T Cells In Protective And Aberrant Immunity
Funder
National Health and Medical Research Council
Funding Amount
$620,205.00
Summary
Despite their prevalence and potential therapeutic value, MAIT cells remain the least studied of all T cells. This program seeks to do paradigm shifting research into the role of MAIT cells in protective immunity to microbes and allergies. Thereby this project will significantly advance fundamental knowledge on MAIT cell biology and could furnish novel immunotherapeutic agents with an enormous potential as alternatives to microbial and allergy treatments, areas of tremendous clinical need.
Defining The Role Of B Lymphocytes In Breast Cancer At Single-cell Resolution
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
B cells, a type of immune cells, are likely protective against breast cancer, albeit through unknown mechanisms. Over the next 5 years I will apply high-resolution profiling and imaging of B cells within breast cancer biopsies to understand their contribution and identify novel clinical targets, leading to better patient outcomes.
Characterization And Targeting Of Precursor Exhausted T Cells (TPEX) For The Treatment Of Chronic Infection And Cancer
Funder
National Health and Medical Research Council
Funding Amount
$606,009.00
Summary
The recent discovery of precursor exhausted CD8 T cells (TPEX) has not only allowed us to conceptualize our understanding of how chronic T cell responses are maintained over long periods of time, but also resulted in a new understanding of the mechanisms underpinning checkpoint inhibition. I will undertake critical characterization of these TPEX in chronic viral infections with the goal to reveal phenotypic and functional properties, which will serve as potential novel targets for immunotherapy.