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Discovery Early Career Researcher Award - Grant ID: DE120101340
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Subversion of innate immune responses by pathogenic Escherichia coli. This project will determine how bacteria that cause diarrhoeal diseases prevent the immune system from signalling efficiently. It will provide important information not only about how the bacteria establish disease, but also provide insight into the host response in the early stages of infection.
Discovery Early Career Researcher Award - Grant ID: DE120100691
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Argonaute proteins and the mammalian antiviral response. Awarded the Nobel Prize for Medicine in 2006, RNA interference (RNAi) is a natural process that plants use to attack viruses. Humans possess all of the tools for RNAi, but whether it is used for antiviral defense is unknown. This project aims to uncover this immune process which will open new avenues to treat virus infections, from influenza to HIV.
Discovery Early Career Researcher Award - Grant ID: DE220101491
Funder
Australian Research Council
Funding Amount
$443,312.00
Summary
A molecular investigation into metabolite-mediated T cell immunity. This project aims to undertake discovery research to investigate the roles of metabolites in T cell immunity. This project expects to generate new knowledge in the areas of cellular biology and immunology by using cutting-edge molecular and immunological approaches. This will provide fundamental insights into the mechanisms that govern microbial metabolite-based T cell immunity, which may advise future research into vaccines or ....A molecular investigation into metabolite-mediated T cell immunity. This project aims to undertake discovery research to investigate the roles of metabolites in T cell immunity. This project expects to generate new knowledge in the areas of cellular biology and immunology by using cutting-edge molecular and immunological approaches. This will provide fundamental insights into the mechanisms that govern microbial metabolite-based T cell immunity, which may advise future research into vaccines or therapeutics. In addition to knowledge gains, expected outcomes of this project include the development of innovative methodology and building international collaborations to enhance national research capabilities. This will place Australia at the forefront of conceptually innovative discovery in the life sciences.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101591
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Novel postsynaptic functions of the microtubule-associated protein tau. The protein tau is present in abnormal deposits in brains of individuals with dementia. The main aim of this project is to unravel and understand in detail new roles of tau in neurons and thus shed new light into normal brain function. Understanding these new functions of tau will aid in identifying new ways to treat these debilitating diseases.
Discovery Early Career Researcher Award - Grant ID: DE230100998
Funder
Australian Research Council
Funding Amount
$444,576.00
Summary
Should I stay or should I go? How brain stem cells leave quiescence. Most adult stem cells in our brains are sleeping (quiescent). Quiescence helps ensure animals have a lifelong population of brain stem cells, which is crucial for the maintenance of brain circuitry. This project aims to investigate how this process is regulated at a molecular level. This project expects to define the molecular playbook controlling quiescence and explain why brain stem cells progress into deeper states of quiesc ....Should I stay or should I go? How brain stem cells leave quiescence. Most adult stem cells in our brains are sleeping (quiescent). Quiescence helps ensure animals have a lifelong population of brain stem cells, which is crucial for the maintenance of brain circuitry. This project aims to investigate how this process is regulated at a molecular level. This project expects to define the molecular playbook controlling quiescence and explain why brain stem cells progress into deeper states of quiescence during aging by combining novel tissue culture and genetic models, where brain stem cells have disrupted quiescence, with innovative methods of reading gene expression. The benefits of these outcomes include the development of methods to control the quiescence of brain stem cells for bioengineering purposes.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100407
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Biology of immune cells. This project aims to study immune cells that target harmful microbes by recognising by-products of their metabolism, and develop methods modulating their function. In particular, it aims to determine the immune recognition of the full range of microbial metabolites that activate these cells and unravel the mechanisms behind tolerance to nutrition-derived metabolites. This project is a potential opportunity for Australia to maximise its competitive edge in this field and ....Biology of immune cells. This project aims to study immune cells that target harmful microbes by recognising by-products of their metabolism, and develop methods modulating their function. In particular, it aims to determine the immune recognition of the full range of microbial metabolites that activate these cells and unravel the mechanisms behind tolerance to nutrition-derived metabolites. This project is a potential opportunity for Australia to maximise its competitive edge in this field and develop immune-modulatory agents ultimately leading to socioeconomic benefit.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100432
Funder
Australian Research Council
Funding Amount
$394,308.00
Summary
Defining the mechanisms of tissue-resident memory T cell development. We have recently identified a subset of T cells that reside at points of pathogen entry where they can effectively control infection. The ability of these T cells to offer local immunity has caused a paradigm shift in our view of how T cells protect against infection, drastically changing the way we think about designing T cell vaccines. This project aims to characterise this novel T cell subset, defining the fundamental requi ....Defining the mechanisms of tissue-resident memory T cell development. We have recently identified a subset of T cells that reside at points of pathogen entry where they can effectively control infection. The ability of these T cells to offer local immunity has caused a paradigm shift in our view of how T cells protect against infection, drastically changing the way we think about designing T cell vaccines. This project aims to characterise this novel T cell subset, defining the fundamental requirements for their formation and maintenance. This will lead to a greater understanding of their biology, which will be of significance for the development of novel vaccination strategies.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102961
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The role of the unfolded protein response in tau neurobiology and pathology. The main role of the protein tau is the stabilisation of the scaffolding of cells. In a group of dementias, tau forms abnormal clumps within the cells of the brain causing them to die. This project will investigate the cellular processes involved in normally preventing tau proteins from clumping and their role in the development of the abnormal tau clumps.
Discovery Early Career Researcher Award - Grant ID: DE150101578
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
How does neurogenesis in the adult hippocampus influence learning & memory? One of the primary brain structures critical for learning and memory in animals and humans is the hippocampus, where regulated production of new neurons throughout life (i.e. adult neurogenesis) underpins these cognitive functions. The project aims to unravel how adult-born neurons exert their influence over behaviour by determining when newly born neurons become critical for behaviour and the connections made by these c ....How does neurogenesis in the adult hippocampus influence learning & memory? One of the primary brain structures critical for learning and memory in animals and humans is the hippocampus, where regulated production of new neurons throughout life (i.e. adult neurogenesis) underpins these cognitive functions. The project aims to unravel how adult-born neurons exert their influence over behaviour by determining when newly born neurons become critical for behaviour and the connections made by these cells within the hippocampal network. It aims to provide fundamental new insight into the stages at which these neurons are important for the acquisition of spatial task versus the recall of spatial tasks.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101300
Funder
Australian Research Council
Funding Amount
$423,711.00
Summary
Lipopolysaccharide-induced macrophage extracellular traps in host defence. The innate immune system is the first line of defence against invading microbes. Macrophages are key innate immune cells that deploy antimicrobial responses to clear infection and restore health. There are many critical unanswered questions on the molecular mechanisms that drive macrophage inflammatory and antimicrobial pathways. This project aims to elucidate a novel inflammatory mechanism that immobilises and kills inva ....Lipopolysaccharide-induced macrophage extracellular traps in host defence. The innate immune system is the first line of defence against invading microbes. Macrophages are key innate immune cells that deploy antimicrobial responses to clear infection and restore health. There are many critical unanswered questions on the molecular mechanisms that drive macrophage inflammatory and antimicrobial pathways. This project aims to elucidate a novel inflammatory mechanism that immobilises and kills invading bacteria via newly discovered structures made by dying macrophages called extracellular traps. Insight we gain by interrogating this immune cell signalling pathway, called the non-canonical inflammasome, will add valuable knowledge to our fundamental understanding of mammalian inflammation and anti-microbial responses
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