Optimising disease surveillance to support decision-making. COVID-19 has demonstrated the critical role of epidemic data and analytics in guiding government response to pandemic threats, reducing disease and saving lives. The demand for epidemic analytics for response to threats of national significance will only grow. The goals of this project are to 1) determine the combination(s) of surveillance methods that provide the most useful data for epidemic analysis and 2) translate these findings in ....Optimising disease surveillance to support decision-making. COVID-19 has demonstrated the critical role of epidemic data and analytics in guiding government response to pandemic threats, reducing disease and saving lives. The demand for epidemic analytics for response to threats of national significance will only grow. The goals of this project are to 1) determine the combination(s) of surveillance methods that provide the most useful data for epidemic analysis and 2) translate these findings into the blueprint for a next-generation infectious disease surveillance system for Australia. We will use a simulation-evaluation approach, coupling methods from infectious disease modelling with those from information theory optimal design. Outcomes will enable more tailored and effective pandemic response.Read moreRead less
Optimising the Utility of Injury Surveillance Systems for Injury Prevention in Active Populations. Promotion of physical activity is a key national health priority and a major focus for the Australian Defence Force to achieve and maintain operational fitness. Unfortunately, these goals are associated with the negative effects of increased injury occurrence and substantial related costs. Civilian and military injury surveillance systems inform injury prevention priorities and interventions but re ....Optimising the Utility of Injury Surveillance Systems for Injury Prevention in Active Populations. Promotion of physical activity is a key national health priority and a major focus for the Australian Defence Force to achieve and maintain operational fitness. Unfortunately, these goals are associated with the negative effects of increased injury occurrence and substantial related costs. Civilian and military injury surveillance systems inform injury prevention priorities and interventions but research is required to maximise their performance and utility. The project aims to 1) determine the extent to which current systems meet user requirements 2) assess utility and reliability of these systems specifically for active populations and 3) develop recommendations for future systems development and improved user application.Read moreRead less
Designing new generation adjuvants for allergy and parasite vaccines. Allergy vaccines have the potential to provide a permanent cure against many allergic diseases, currently affecting 20-30 per cent of people in developed countries. This project will study how allergy vaccines work and how we can improve their effectiveness and safety.
Revealing the evolutionary and ecological dynamics of avian influenza virus. This project aims to understand how avian influenza virus (AIV) emerges, evolves and spreads in wild birds. AIV has the potential to devastate the poultry industry and cause human pandemics, but the factors that shape the genetic diversity of AIV in its wild bird reservoir are poorly understood. The project plans to combine genomic, ecological and phylogenetic approaches to reveal key aspects of AIV evolution, as well a ....Revealing the evolutionary and ecological dynamics of avian influenza virus. This project aims to understand how avian influenza virus (AIV) emerges, evolves and spreads in wild birds. AIV has the potential to devastate the poultry industry and cause human pandemics, but the factors that shape the genetic diversity of AIV in its wild bird reservoir are poorly understood. The project plans to combine genomic, ecological and phylogenetic approaches to reveal key aspects of AIV evolution, as well as the risk for future viral emergence. Using sampling sites in Australia and Antarctica, it plans to investigate AIV diversity, the evolutionary dynamics of AIV in wild birds and poultry, and the role played by environmental transmission in AIV ecology.Read moreRead less
Sexualised Deepfakes: Predictors, Consequences, Responses and Prevention. Artificial Intelligence is changing how perpetrators sexually abuse. Yet little research has explored this, and laws and digital platforms are failing to keep pace. This project aims to identify the predictors, harms and consequences of sexualised deepfakes (a form of Artificial Intelligence-Facilitated Abuse) and produce evidence to inform legal, technological and social responses to this growing problem. Expected outcome ....Sexualised Deepfakes: Predictors, Consequences, Responses and Prevention. Artificial Intelligence is changing how perpetrators sexually abuse. Yet little research has explored this, and laws and digital platforms are failing to keep pace. This project aims to identify the predictors, harms and consequences of sexualised deepfakes (a form of Artificial Intelligence-Facilitated Abuse) and produce evidence to inform legal, technological and social responses to this growing problem. Expected outcomes include increased understanding of the drivers of abuse, the development of improved prevention resources and social, technological and legal responses for digital platforms, organisations and government. Expected benefits include improved laws, policies and practices to prevent Artificial Intelligence-Facilitated Abuse.Read moreRead less
Mid-infrared quantum dots for room temperature photodetectors and emitters. This project aims to develop new technologies for mid-wave infrared (MWIR) cameras based on quantum dots (QDs). These will include MWIR photodetectors based on QD-sensitised photodetectors and MWIR emitters based on QD electroluminescence devices.
This project expects to generate new knowledge in MWIR QDs and in devices that sense and emit infrared light.
Expected outcomes of the project include MWIR cameras that are ....Mid-infrared quantum dots for room temperature photodetectors and emitters. This project aims to develop new technologies for mid-wave infrared (MWIR) cameras based on quantum dots (QDs). These will include MWIR photodetectors based on QD-sensitised photodetectors and MWIR emitters based on QD electroluminescence devices.
This project expects to generate new knowledge in MWIR QDs and in devices that sense and emit infrared light.
Expected outcomes of the project include MWIR cameras that are smaller, lighter, lower in power consumption and cheaper than existing technologies.
This project is expected to provide significant benefits, such as dramatic reductions in the cost of infrared cameras and sensors. The high cost of infrared cameras currently limits their use in Australia largely to defence.
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Can and should we link data at a national level? Vaccine safety surveillance: A case study. This project provides many benefits for the community, exploring the legal and ethical issues around consent for data linkage, convening Citizens' Juries to weigh the evidence and make recommendations. It addresses National Research Priorities: Promoting and Maintaining Good Health and Safeguarding Australia as well as National Collaborative Research Infrastructure Strategy priorities. It uses vaccine sa ....Can and should we link data at a national level? Vaccine safety surveillance: A case study. This project provides many benefits for the community, exploring the legal and ethical issues around consent for data linkage, convening Citizens' Juries to weigh the evidence and make recommendations. It addresses National Research Priorities: Promoting and Maintaining Good Health and Safeguarding Australia as well as National Collaborative Research Infrastructure Strategy priorities. It uses vaccine safety surveillance as a case study to evaluate the effectiveness of data linkage (through linking Commonwealth immunisation data to state hospital data) and the methodologies and lessons learnt from cross jurisdictional data linkage can be transferred to other areas. Read moreRead less
Dissecting the Parameters for the Generation of Cytotoxic T Lymphocyte Immunity. This project aims to identify mechanisms by which antigen-presenting cells, such as dendritic cells, prime CD8+ T cells to generate effector and memory populations at the molecular level. The specific intention is to identify reagents capable of licensing dendritic cells, and examine the down-stream gene products/pathways generated by these signals using microarray analyses. Such knowledge will provide new insight i ....Dissecting the Parameters for the Generation of Cytotoxic T Lymphocyte Immunity. This project aims to identify mechanisms by which antigen-presenting cells, such as dendritic cells, prime CD8+ T cells to generate effector and memory populations at the molecular level. The specific intention is to identify reagents capable of licensing dendritic cells, and examine the down-stream gene products/pathways generated by these signals using microarray analyses. Such knowledge will provide new insight into CTL generation by providing greater understanding of how multicellular systems function both at the cellular and molecular level.Read moreRead less
Imaging of immune responses to pathogens in vivo. This proposal represents an excellent opportunity for Australian science to participate in state-of-the-art research into the immune system and to be internationally competitive with the best researchers in the field. By combining advanced microscopy techniques with well developed biological models used by researchers at the University of Melbourne, this project will greatly improve our understanding of the dynamic interactions that occur betwee ....Imaging of immune responses to pathogens in vivo. This proposal represents an excellent opportunity for Australian science to participate in state-of-the-art research into the immune system and to be internationally competitive with the best researchers in the field. By combining advanced microscopy techniques with well developed biological models used by researchers at the University of Melbourne, this project will greatly improve our understanding of the dynamic interactions that occur between cells of the immune system during infectious diseases. The insight provided by this project will facilitate the design of better vaccines for protection against diseases, including influenza.Read moreRead less