A NOVEL MOUSE MODEL TO INVESTIGATE THE MECHANISMS OF VIRUS-INDUCED ARTHRITIS
Funder
National Health and Medical Research Council
Funding Amount
$336,000.00
Summary
We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators ( ....We have developed a novel animal model by which to study arthritic disease caused by insect-transmitted viruses known as arboviruses. The existence of this model and novel reagents provides an excellent opportunity to further explore the basic mechanisms of infectious disease in a complete functioning animal, rather than specific cultured cells. The study will use modern approaches in molecular and cellular biology to achieve this goal. The production by our immune systems of soluble mediators (cytokines-chemokines) and antibodies is an overwhelming positive aspect of our physiological response to infection by microbes. Protection from disease by these immune compounds can happen naturally, or the body's ability to produce these factors can be exploited to our benefit via the administration of vaccines. However, these factors can also be detrimental to the host contributing to severe disease. For instance, work performed almost 40 years ago showed for the first time that under particular conditions, antibodies against viruses can enhance infection, instead of inhibiting infection as normally seen. In the intervening years work by scientists all over the world has associated antibody-dependent enhancement (ADE) of infection to many types of viruses; ADE is even thought to be a risk factor to serious disease with dengue virus, and has been shown in vitro for the AIDS virus and Ebola virus. We have recently discovered a molecular mechanism which explains how antibody enhances viral infection in vitro. In studies on immune cells infected with Ross River Virus (RRV) we found that infection helped by antibody resulted in the specific disruption to the production of cellular chemicals which are toxic to viruses. Are these mechanisms of antibody-enhanced infection also found in animals? Will such mode of infection cause enhanced disease and tissue pathology (arthritis) in animals?Read moreRead less
The Unique Nature Of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10
Funder
National Health and Medical Research Council
Funding Amount
$699,031.00
Summary
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.
The canonical stratification of jet spaces. Singularities occur everywhere in nature, from the formation and collapse of stars to the morphology of living embryos. They appear whenever the geometry of surfaces or spaces undergoes a process of twisting, folding, or collapsing on itself. Singularity Theory is the study of such phenomena, an important branch of modern mathematics which has close connections with many other branches of mathematics and applied sciences. Singularity Theory lies at the ....The canonical stratification of jet spaces. Singularities occur everywhere in nature, from the formation and collapse of stars to the morphology of living embryos. They appear whenever the geometry of surfaces or spaces undergoes a process of twisting, folding, or collapsing on itself. Singularity Theory is the study of such phenomena, an important branch of modern mathematics which has close connections with many other branches of mathematics and applied sciences. Singularity Theory lies at the crossroads of the paths connecting the most important areas of applications of mathematics with its most abstract parts. Analytic Singularity Theory is a central part of Singularity Theory. This project would lead to substantially new advancements in Analytic Singularity Theory.Read moreRead less
Early settlements in Upper Burma (Myanmar): an experiment in urban living. This project directly increases access for Australian research to a previously self-isolated nation, Myanmar. It contributes to better understanding of our region and our world by examining how past communities worked together and how they dealt with social and environmental stress.
Chorasmian temples: an archaeological study of early Zoroastrianism and its precursors in Central Asia. The project is a collaboration with the Uzbek Academy of Sciences. National benefits to Australia are in international relations and in broadening our understanding of cultural issues in the potentially volatile and politically significant region of Central Asia. The team has developed a high profile in Uzbekistan and internationally, reflecting well on Australia's cultural strengths, intern ....Chorasmian temples: an archaeological study of early Zoroastrianism and its precursors in Central Asia. The project is a collaboration with the Uzbek Academy of Sciences. National benefits to Australia are in international relations and in broadening our understanding of cultural issues in the potentially volatile and politically significant region of Central Asia. The team has developed a high profile in Uzbekistan and internationally, reflecting well on Australia's cultural strengths, international involvement and support for developing countries in Asia. Our research features regularly in the Uzbek media and has the personal approval of President Karimov. We are involved with Zoroastrian and Parsi communities in Australia and overseas, particularly in India and the USA, and our results are published regularly in the community press.Read moreRead less
East meets West: an archaeological study of early contact between China and Eurasia. The project will link Chinese and Australian researchers in a collaborative programme exploring the origins of cultural contact between China and the West. Through the work of a team of international specialists, this fresh initiative will bring western analytical techniques together with Chinese archaeological experience to create a new and robust picture of the evidence for early cultural contact. From this we ....East meets West: an archaeological study of early contact between China and Eurasia. The project will link Chinese and Australian researchers in a collaborative programme exploring the origins of cultural contact between China and the West. Through the work of a team of international specialists, this fresh initiative will bring western analytical techniques together with Chinese archaeological experience to create a new and robust picture of the evidence for early cultural contact. From this we will study the early movements of Indo-European populations and examine the question of the origins of early metal production in China.Read moreRead less
With or without pots: Investigating the archaeology of human settlement on Santa Isabel, western Solomon Islands. Following the recent civil unrest in the Solomon Islands, the SI National and Provincial Governments, as well as community bodies, have identified a better understanding of the past and the revival of traditional systems and knowledge (Kastom) as a route to stability and cohesion throughout the region. This study responds to direct requests from the Santa Isabel community for assist ....With or without pots: Investigating the archaeology of human settlement on Santa Isabel, western Solomon Islands. Following the recent civil unrest in the Solomon Islands, the SI National and Provincial Governments, as well as community bodies, have identified a better understanding of the past and the revival of traditional systems and knowledge (Kastom) as a route to stability and cohesion throughout the region. This study responds to direct requests from the Santa Isabel community for assistance with archaeological research and the recording of cultural histories. By assisting a Pacific neighbour to develop a more durable, internally generated basis for social and economic development, Australia not only encourages security in the region, but also increases its engagment with and understanding of adjacent cultures.Read moreRead less
Immunomodulatory Vaccines In The Treatment Of Peanut Allergy
Funder
National Health and Medical Research Council
Funding Amount
$678,899.00
Summary
Peanut allergy is the most common cause of food-induced anaphylactic reactions in Australia and is a major burden to our healthcare system. Current clinical practice advice dietary avoidance to prevent fatal anaphylactic responses. We propose the use of an immunomodulatory vaccine to re-write the immune response to peanut antigens, from an allergic to a tolerant phenotype. This study will provide novel insights into rational approaches for manipulating immune memory to food allergens.
The Role Of Novel G-Protein Coupled Receptors In Immunity And Inflammatory Diseases
Funder
National Health and Medical Research Council
Funding Amount
$69,684.00
Summary
Recent advances in molecular biology techniques have resulted in the identification of many novel GPCRs. Novel GPCRs expressed selectively on immune cells display a potential target for novel therapies for inflammatory diseases such as Asthma and Rheumatoid arthritis. This project aims to define the activity and significance of a novel group of GPCRs, the GPR40 family. Outcomes of this project will be further understanding of immune cell development and inflammatory disease development.
Elam in the 2nd millennium B.C.: A multi-regional approach. Although it was one of the Near East's most powerful ancient states, Elam has received less scholarly attention than its neighbours. Using an innovative approach targeting three unexcavated sites (Deh-e Now, Tepe Senjar and Liyan) in Iran, this project aims to investigate Elam at its height during the 2nd millennium B.C. Archaeological excavations will be undertaken over a 5 year period and materials which have rarely received attention ....Elam in the 2nd millennium B.C.: A multi-regional approach. Although it was one of the Near East's most powerful ancient states, Elam has received less scholarly attention than its neighbours. Using an innovative approach targeting three unexcavated sites (Deh-e Now, Tepe Senjar and Liyan) in Iran, this project aims to investigate Elam at its height during the 2nd millennium B.C. Archaeological excavations will be undertaken over a 5 year period and materials which have rarely received attention in the past will be analysed using a wide range of scientific techniques. The project will be the first major investigation of Elam in almost 25 years.Read moreRead less