Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The pr ....Placental nutrient transport shows how complex traits evolve. This project aims to use amino acid transport in the vertebrate placenta as a model to demonstrate how genes are recruited and modified to produce a major organ. Using an innovative combination of a new technology, selected reaction monitoring, and transcriptomic and molecular approaches, plus carefully selected Australian species pairs, this project will study the evolution of a complex trait (placental amino acid transport). The project will provide fundamental advances in our knowledge of the nutrient transport during pregnancy that is required to produce a healthy baby.Read moreRead less
Combining biomechanics and movement ecology of kangaroos and relatives. Kangaroos and their relatives are unique in their body form, hopping gait and by the fact that increased speed does not come at an increased energetic cost. This project aims to build 3D musculoskeletal models to understand how muscles and tendons interact, enabling greater distances to be travelled using less energy. Further, it will use animal tracking devices and machine-learning tools to quantify movements in the wild. T ....Combining biomechanics and movement ecology of kangaroos and relatives. Kangaroos and their relatives are unique in their body form, hopping gait and by the fact that increased speed does not come at an increased energetic cost. This project aims to build 3D musculoskeletal models to understand how muscles and tendons interact, enabling greater distances to be travelled using less energy. Further, it will use animal tracking devices and machine-learning tools to quantify movements in the wild. This framework will provide novel insights into how energetics, morphology, and habitat have shaped the evolution of this unique group. This may open doors to a range of future ecological, physiological, and conservation studies and provide biological inspiration for energetically efficient robotic and assistive devices.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100585
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Does foot shape even matter? Rethinking the function of the human foot. Human feet are unique in shape and structure, having evolved to allow upright locomotion. Despite their importance, we don’t understand how foot shape and structure facilitates upright locomotion.This DECRA aims to explore the relationship between foot morphology and foot function. I will close a large knowledge gap by applying novel experimental and shape modelling approaches to provide unprecedented insights into human foo ....Does foot shape even matter? Rethinking the function of the human foot. Human feet are unique in shape and structure, having evolved to allow upright locomotion. Despite their importance, we don’t understand how foot shape and structure facilitates upright locomotion.This DECRA aims to explore the relationship between foot morphology and foot function. I will close a large knowledge gap by applying novel experimental and shape modelling approaches to provide unprecedented insights into human foot function. The primary expected outcome is a detailed understanding of how foot shape and structure influences our ability to walk and run. This research will create a paradigm shift in how we think about feet in the context of human evolution, human athletic performance and athletic footwear design.Read moreRead less
Heat regulation by the fibre types in muscle. Mammals maintain a constant core body temperature by generating heat in resting muscles in response to changes in the environmental temperatures. This project aims to show how the fibre types that make up skeletal muscles regulate heat generation against other muscle function, to maintain core body temperature and the normal movement and posture of the mammal. Project outcomes include defining, for the first time, how heat generation in the muscles o ....Heat regulation by the fibre types in muscle. Mammals maintain a constant core body temperature by generating heat in resting muscles in response to changes in the environmental temperatures. This project aims to show how the fibre types that make up skeletal muscles regulate heat generation against other muscle function, to maintain core body temperature and the normal movement and posture of the mammal. Project outcomes include defining, for the first time, how heat generation in the muscles of the body is regulated. This should provide critical knowledge of mammalian evolution and ways to manipulate metabolism, which may provide ways to assist with achieving a desired meat quality and yield in beef and other commercially important animals.Read moreRead less
Interrogating the extremes of skeletal muscle plasticity in vertebrates. This project aims to interrogate how muscles adapt to growth and endurance stimuli at different stages of life, relevant to addressing challenges facing the world’s ageing population. Using innovative gene technologies and molecular physiology in zebrafish and mice, this project will answer important, unresolved questions in muscle biology. The project will generate knowledge needed to develop interventions to improve quali ....Interrogating the extremes of skeletal muscle plasticity in vertebrates. This project aims to interrogate how muscles adapt to growth and endurance stimuli at different stages of life, relevant to addressing challenges facing the world’s ageing population. Using innovative gene technologies and molecular physiology in zebrafish and mice, this project will answer important, unresolved questions in muscle biology. The project will generate knowledge needed to develop interventions to improve quality of life for older Australians and address the physical realities of an ageing workforce. Benefits extend to enhancing workplace safety and productivity, improving farming efficiencies for livestock and aquaculture industries, and training emerging leaders in the biological sciences.Read moreRead less
Skin in the game: biomimetics, fitness and the springtail cuticle. This project aims to examine the relationship between cuticle (skin) properties, water balance, and fitness in springtails, key players in soil systems. Springtail cuticles are diverse, responsive, and extremely resistant to wetting by water, alcohol and other substances. Their Australian diversity has not been well explored for biomimetic new materials. This project expects to explore options for new applications in materials sc ....Skin in the game: biomimetics, fitness and the springtail cuticle. This project aims to examine the relationship between cuticle (skin) properties, water balance, and fitness in springtails, key players in soil systems. Springtail cuticles are diverse, responsive, and extremely resistant to wetting by water, alcohol and other substances. Their Australian diversity has not been well explored for biomimetic new materials. This project expects to explore options for new applications in materials science and engineering by generalising the cuticle structure-function relationship. Expected outcomes are new information to harness for industry the diversity of nature’s self-cleaning, water repellent surfaces. Significant benefits lie in potential new biomimetic manufacturing options.Read moreRead less
How are sperm mitochondria eliminated after fertilisation . The fact that mitochondria are inherited exclusively through the maternal germ-line is fundamental feature of sexual reproduction in all but a few organisms. This uni-parental inheritance is thought to prevent genetic conflict between different mitochondrial genomes. The mechanisms controlling uniparental inheritance involve eliminating the sperm mitochondria soon after fertilisation. We will investigate 2 possible mechanisms, (1) acti .... How are sperm mitochondria eliminated after fertilisation . The fact that mitochondria are inherited exclusively through the maternal germ-line is fundamental feature of sexual reproduction in all but a few organisms. This uni-parental inheritance is thought to prevent genetic conflict between different mitochondrial genomes. The mechanisms controlling uniparental inheritance involve eliminating the sperm mitochondria soon after fertilisation. We will investigate 2 possible mechanisms, (1) active destruction and (2) passive dilution. The results will help explain how heteroplasmy is avoided in order to maintain the fitness of organisms including animals and humans. The results will have long term insights into improving breeding in agriculture and in the prevention of mitochondrial genetic disease.Read moreRead less
Understanding why mammalian eggs have so much mitochondrial DNA . During oocyte growth there is massive increase in the replication of mitochondrial DNA so that each ovulated egg has 200,000-400,000 copies of the mitochondrial genome. This mitochondrial compliment will provide the template for all mitochondrial DNA in the subsequent organism. The established role of mitochondria is to provide energy in the form of ATP, but they are also known to be highly adaptive to the metabolic and energetic ....Understanding why mammalian eggs have so much mitochondrial DNA . During oocyte growth there is massive increase in the replication of mitochondrial DNA so that each ovulated egg has 200,000-400,000 copies of the mitochondrial genome. This mitochondrial compliment will provide the template for all mitochondrial DNA in the subsequent organism. The established role of mitochondria is to provide energy in the form of ATP, but they are also known to be highly adaptive to the metabolic and energetic state of the cell. In this project, we will use genetic approaches to decrease the amount of oocyte mitochondrial DNA by 90%. We will examine how this influences mitochondrial organisation, oocyte metabolism and embryo development. This new knowledge will provide insights into animal breeding and human health.Read moreRead less
Adaptive Morphology and Evolution of Invasive Rabbits and Hares. This project aims to uncover the morphological variation that allows rapid adaptive evolution in two invasive species, the rabbit and hare. This project expects to generate new knowledge at the interface between invasion biology and evolutionary biology, using cutting-edge methods to phenotype widespread populations. This project will address key inter-related hypotheses of rapid adaptive evolution at temporal, spatial and phylogen ....Adaptive Morphology and Evolution of Invasive Rabbits and Hares. This project aims to uncover the morphological variation that allows rapid adaptive evolution in two invasive species, the rabbit and hare. This project expects to generate new knowledge at the interface between invasion biology and evolutionary biology, using cutting-edge methods to phenotype widespread populations. This project will address key inter-related hypotheses of rapid adaptive evolution at temporal, spatial and phylogenetic scales, particularly about changing morphologies involved role in locomotion and dispersal ability. Expected outcomes of this project include a comprehensive phenotypic database of these two species and identifying how these invasive species are adapting to the Australian landscape.Read moreRead less
Using Drosophila to analyse a master regulator of epithelial homeostasis. Aims:
This proposal aims to use genetic and cell biological analysis of the vinegar fly, Drosophila, to identify the function of the grainyhead gene in intestinal regeneration.
Significance:
This gene is conserved in all animal species and appears to be a master regulator of epithelial tissue development but it is unclear how it can both influence stem cell maintenance and production of functional cell types.
Expected out ....Using Drosophila to analyse a master regulator of epithelial homeostasis. Aims:
This proposal aims to use genetic and cell biological analysis of the vinegar fly, Drosophila, to identify the function of the grainyhead gene in intestinal regeneration.
Significance:
This gene is conserved in all animal species and appears to be a master regulator of epithelial tissue development but it is unclear how it can both influence stem cell maintenance and production of functional cell types.
Expected outcomes:
We will identify a new mechanism that governs tissue development, and introduce new imaging and genetic technologies to the Australian research community.
Benefit:
We expect potential economic and commercial interest in development of new gene analysis tools and biotechnological tissue manipulation applications.Read moreRead less