An integrated model for assessing health effects of nanoparticle inhalation. This project aims to examine the associated risks of nanoparticle inhalation on heath by developing a toxicological predictive tool for health risk assessment. The outcomes of this research will lead to greatly improved preventative measures, thereby reducing occupational diseases and the health socio-economic burden of Australia.
A Multiscale Modelling Platform for Nanoparticle Inhalation Risk Assessment. This project aims to explore the health risks caused by nanoparticle inhalation and its penetration through respiratory mucus and tissue cells. Exposure to nanoparticles has the potential to cause serious and possibly fatal health effects. An understanding of nanoparticle toxicology would enable us to appropriately protect the public’s health and safety. The project plans to consider human respiratory anatomy and physio ....A Multiscale Modelling Platform for Nanoparticle Inhalation Risk Assessment. This project aims to explore the health risks caused by nanoparticle inhalation and its penetration through respiratory mucus and tissue cells. Exposure to nanoparticles has the potential to cause serious and possibly fatal health effects. An understanding of nanoparticle toxicology would enable us to appropriately protect the public’s health and safety. The project plans to consider human respiratory anatomy and physiology and use advanced computer modelling and experimental techniques to evaluate the health risk of exposure to the burgeoning number of nanomaterials found in consumer products. The expected outcome of the project is a predictive tool that determines nanoparticle exposure risk and its health consequences.Read moreRead less
Robust, valid and interpretable deep learning for quantitative imaging. One of the biggest challenges in employing artificial intelligence is the “black-box” nature of the models used. This project aims to improve the effectiveness and trustworthiness of deep learning within quantitative magnetic resonance imaging. Deep learning has great promise in speeding-up complex image processing tasks, but currently suffers from variable data inputs, predictions are not guaranteed to be plausible and it i ....Robust, valid and interpretable deep learning for quantitative imaging. One of the biggest challenges in employing artificial intelligence is the “black-box” nature of the models used. This project aims to improve the effectiveness and trustworthiness of deep learning within quantitative magnetic resonance imaging. Deep learning has great promise in speeding-up complex image processing tasks, but currently suffers from variable data inputs, predictions are not guaranteed to be plausible and it is not clear to the end user how reliable the results are. The outcomes intend to deliver advanced knowledge and capability in artificial intelligence and machine learning that Australia urgently needs to capitalise on bringing deep learning into practical applications delivering economic, commercial and social impact.Read moreRead less
Modelling and simulation of self-organised behaviour in biological and bio-inspired systems. Understanding self-organised systems is fundamental in biology and bio-inspired engineering. The project develops sophisticated mathematical modelling techniques and high performance simulation methods for such systems. This will increase our capacity to explain complex biological behaviour and to produce reliable bio-inspired engineering solutions
Subject-specific computational models for accurate evaluation of muscle function in human locomotion. The purpose of this project is to advance current understanding of muscle function during human locomotion. The most significant outcome will be the development of novel computational tools that can play a pivotal role in the healthcare industry through the prevention, diagnosis and treatment of movement disorders.
Large-scale computational modelling of epidemics in Australia. The project aims to develop novel computational epidemiological models to contribute to guidelines for optimal prophylaxis, vaccination and case management. Emerging threats posed by infectious diseases and bioterrorism could have dramatic effects on the Australian population, productivity and economy. The project aims to improve the accuracy and scope of modern computational epidemiological models by integrating large-scale Census d ....Large-scale computational modelling of epidemics in Australia. The project aims to develop novel computational epidemiological models to contribute to guidelines for optimal prophylaxis, vaccination and case management. Emerging threats posed by infectious diseases and bioterrorism could have dramatic effects on the Australian population, productivity and economy. The project aims to improve the accuracy and scope of modern computational epidemiological models by integrating large-scale Census datasets and explicitly simulating the entire population down to the level of single individuals, coupled with complex network-based and information flow analysis. The intended outcomes include a more precise and efficient forecasting of critical epidemic dynamics, and increased effectiveness of prevention, mitigation and management of socio-economic, socio-ecological and national security crises.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101549
Funder
Australian Research Council
Funding Amount
$395,775.00
Summary
A virtual platform for animal–human inhalation toxicity extrapolation. This project aims to remove the long-lasting barrier in extrapolating data from animals to humans by developing an integrated virtual platform. This project expects to fully resolve inhalation exposure differences in nasal airways between commonly used animal surrogates and humans, which could lay scientific underpinnings in developing rigorous interspecies data conversion schemes. Expected outcomes include a versatile inhala ....A virtual platform for animal–human inhalation toxicity extrapolation. This project aims to remove the long-lasting barrier in extrapolating data from animals to humans by developing an integrated virtual platform. This project expects to fully resolve inhalation exposure differences in nasal airways between commonly used animal surrogates and humans, which could lay scientific underpinnings in developing rigorous interspecies data conversion schemes. Expected outcomes include a versatile inhalation exposure risk assessment tool that can be implemented for any airway compartment, enhanced reliability of animal tests, reduced number of animals for testing. This should provide significant benefits in improving occupational health and safety and promoting National/International regulatory changes. Read moreRead less
An intelligent machine modelling assistant for combinatorial optimisation. This project aims to discover key fundamental technologies for automating assistance to non-expert users in the formulation of mathematical models. Through automating the modelling of combinatorial optimization problems, this research will generate new knowledge to address the fundamental challenges of automatic mathematical modelling. This intelligent assistant will enable synthesis of new mathematical models through th ....An intelligent machine modelling assistant for combinatorial optimisation. This project aims to discover key fundamental technologies for automating assistance to non-expert users in the formulation of mathematical models. Through automating the modelling of combinatorial optimization problems, this research will generate new knowledge to address the fundamental challenges of automatic mathematical modelling. This intelligent assistant will enable synthesis of new mathematical models through the utilisation of pioneering natural language processing components and novel custom-made machine-readable knowledge bases. The outcome of this research will broaden access to high-quality models by non-expert workforce and alleviate the shortage of expert mathematicians, bringing significant social and economic benefits.Read moreRead less
Integration of high-speed dynamic x-ray imaging and patient-specific computational modelling for non-invasive assessment of knee-joint function. The project will establish a new capability for the prevention and treatment of osteoarthritis (joint disease) that will place Australia at the forefront of biomedical engineering research internationally. The ability to integrate high-speed, mobile, x-ray imaging of joint motion with patient-specific computer modelling is unique globally.
Industrial Transformation Research Hubs - Grant ID: IH210100051
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
The ARC Research Hub for Digital Bioprocess Development. The ARC Hub for Digital Bioprocess Development aims to assist the Biopharma industry by increasing digital innovation, productivity and competitiveness. An interdisciplinary team of engineers, scientists and computing specialists will develop digitally integrated advanced manufacturing processes and a platform for industry adoption. The program will address key bioprocessing research challenges and develop new process and digital models th ....The ARC Research Hub for Digital Bioprocess Development. The ARC Hub for Digital Bioprocess Development aims to assist the Biopharma industry by increasing digital innovation, productivity and competitiveness. An interdisciplinary team of engineers, scientists and computing specialists will develop digitally integrated advanced manufacturing processes and a platform for industry adoption. The program will address key bioprocessing research challenges and develop new process and digital models that can predict and optimise manufacturing processes, resulting in greater yields, faster and more flexible processes and enhanced product stability. The Hub will transform biopharmaceutical manufacturing and unlock growth opportunities to forge an internationally competitive Australian Biopharma sector.Read moreRead less