Multi-modal, Multi-dimensional Virtual Microscopy for Diagnostic Quantitative Pathology. This project will contribute to the development of a new generation of virtual microscopy (VM) systems that provide new and innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of pathology. These systems have the potential to significantly enhance the efficiency and efficacy of not only primary diagnostic workflows, but also aspects of profi ....Multi-modal, Multi-dimensional Virtual Microscopy for Diagnostic Quantitative Pathology. This project will contribute to the development of a new generation of virtual microscopy (VM) systems that provide new and innovative features capable of significantly increasing the adoption of digital imaging technology throughout the field of pathology. These systems have the potential to significantly enhance the efficiency and efficacy of not only primary diagnostic workflows, but also aspects of proficiency testing and continuing education vital for a vibrant, well regulated discipline. In addition, the project will contribute to our knowledge of the pathology assessed in the screening and diagnosis of cancers such as cervical, lung and bladder cancers.Read moreRead less
Novel Motion Correction Technologies for Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging. The recent development of the world's first prototype combined MR-PET scanner for human use has prompted immense interest. MR-PET is likely to revolutionize clinical diagnosis and basic research, by providing exquisite structural images co-registered with simultaneous functional PET images. We will exploit the as yet unexplored potential for motion information derived from the MR sy ....Novel Motion Correction Technologies for Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging. The recent development of the world's first prototype combined MR-PET scanner for human use has prompted immense interest. MR-PET is likely to revolutionize clinical diagnosis and basic research, by providing exquisite structural images co-registered with simultaneous functional PET images. We will exploit the as yet unexplored potential for motion information derived from the MR system to be used to correct the simultaneously acquired PET data for patient motion. This research is an excellent opportunity for Australian researchers to make important contributions to an emerging technology with high economic potential, and will strengthen Australia's international position in engineering and biomedical systems development.Read moreRead less
Novel Transmission Scanning and Computational Strategies for Quantitative microPET Imaging. Advances in detector technologies have led to the development and commercialisation of small animal imaging systems such as microPET which provide high resolution images of radioactive compounds in live animals, but the images can only be interpreted qualitatively. Our aim is to develop quantitative technologies for these new imaging systems. Major outcomes will include novel methods of measuring and corr ....Novel Transmission Scanning and Computational Strategies for Quantitative microPET Imaging. Advances in detector technologies have led to the development and commercialisation of small animal imaging systems such as microPET which provide high resolution images of radioactive compounds in live animals, but the images can only be interpreted qualitatively. Our aim is to develop quantitative technologies for these new imaging systems. Major outcomes will include novel methods of measuring and correcting for signal loss due to photon interactions in the body and integrated image reconstruction algorithms. This will lead to a new generation of quantitative imaging devices; the new technologies will be directly translatable to clinical imaging systems and will broaden the range of microPET applications in the life sciences.Read moreRead less
New Imaging Instrumentation and Algorithms for the Simultaneous Measurement of Multiple Radio-labelled Probes in vivo. Medical imaging plays an increasingly important role in basic biological research and health care. This project will lead to new imaging technologies that allow the simultaneous measurement of more than one biological process at a time in living subjects, providing new insights into disabling diseases, such as cancer and mental illness. An immediate benefit will be to strengthen ....New Imaging Instrumentation and Algorithms for the Simultaneous Measurement of Multiple Radio-labelled Probes in vivo. Medical imaging plays an increasingly important role in basic biological research and health care. This project will lead to new imaging technologies that allow the simultaneous measurement of more than one biological process at a time in living subjects, providing new insights into disabling diseases, such as cancer and mental illness. An immediate benefit will be to strengthen the expertise in biomedical engineering and instrumentation development in Australia, where we have international leadership. The technologies developed will provide advanced tools for making fundamental biological discoveries and translating them into biotechnological or clinical applications.Read moreRead less
Simultaneous measurement of brain function and behaviour in fully conscious laboratory animals. MicroPET is an advanced imaging technology that measures important biochemical processes, such as enzyme activity rates and receptor binding, in the living rodent brain. However, the requirement for the animal to be anaesthetised precludes the study of behavioural changes in response to sensory or drug stimulus during the imaging study. In this research, we will develop novel motion tracking and compu ....Simultaneous measurement of brain function and behaviour in fully conscious laboratory animals. MicroPET is an advanced imaging technology that measures important biochemical processes, such as enzyme activity rates and receptor binding, in the living rodent brain. However, the requirement for the animal to be anaesthetised precludes the study of behavioural changes in response to sensory or drug stimulus during the imaging study. In this research, we will develop novel motion tracking and computational algorithms that enable microPET to non-invasively image the brains of conscious, freely moving animals while simultaneously observing their behaviour. These new technologies will, for the first time, allow neuroscientists to study the genetic, behavioural and neurochemical correlates of brain disease.Read moreRead less
Special Research Initiatives - Grant ID: SR0354734
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving h ....The Australian Research Network for Medical Devices: advanced technology solutions for patients and practitioners. Medical Device technologies embrace a wide range of scientific, engineering and medical knowledge, with the goal of assisting a clinical professional (doctor or nurse) deliver a service to a patient in an efficacious, cost effective manner. Development of appropriate medical devices, whether for diagnosis, treatment or prevention of disease or disability, is critical to improving health care and reducing health care costs. To be successful, a device must include all relevant disciplines in the research, development and testing phases. This network will bring together these groups, promoting knowledge sharing and cross-disciplinary investigations that illuminate current device limitations and potential solutions.Read moreRead less
Automated pathogen detection using time-gated luminescence microscopy. A rapid and general means of in-situ pathogen identification would benefit the community by ensuring that appropriate treatments can be applied in the early stages of a disease. Patient prognosis is thereby improved and opportunities for multi-drug resistant organisms to arise are limited. Time-gated luminescence microscopy (TgM) exploits persistent luminescence to overcome autofluorescence, a serious problem in pathogen dete ....Automated pathogen detection using time-gated luminescence microscopy. A rapid and general means of in-situ pathogen identification would benefit the community by ensuring that appropriate treatments can be applied in the early stages of a disease. Patient prognosis is thereby improved and opportunities for multi-drug resistant organisms to arise are limited. Time-gated luminescence microscopy (TgM) exploits persistent luminescence to overcome autofluorescence, a serious problem in pathogen detection. Drug-resistant 'Golden Staph' (MRSA) will be used as the model organism to evaluate TgM efficacy. Ultimately however, TgM will be applied for the detection of tuberculosis, a highly contagious disease affecting the respiratory system of more than one-third of the world's population.Read moreRead less
High-Fidelity Modelling for Robotic-Assisted Minimally Invasive Needle Insertion. This project will develop robotic-assisted needle insertion and greatly improve minimally invasive surgery. It will also enhance the establishment of intellectual property for Australian medicine and produce important benefits to the healthcare sector. The proposed symbiotic integration of the systems will advance modelling technologies, and further create new capabilities for a wide range of science and engineerin ....High-Fidelity Modelling for Robotic-Assisted Minimally Invasive Needle Insertion. This project will develop robotic-assisted needle insertion and greatly improve minimally invasive surgery. It will also enhance the establishment of intellectual property for Australian medicine and produce important benefits to the healthcare sector. The proposed symbiotic integration of the systems will advance modelling technologies, and further create new capabilities for a wide range of science and engineering applications. The established methodologies and systems will also provide great potential benefits in many other areas, including microbiology, life sciences and bio/nano-technology. The project's outcomes will further consolidate Australia's position in innovative technologies and international research and development.Read moreRead less
Spectral analysis with selective harmonic emphasis. This project lies under ARC research priority area "Frontier Technologies for Building and Transforming Australian Industries". The signal processing algorithms to be developed in this project will be useful in many important practical applications, which include various bio-medical imaging modalities, beamforming, radar, sonar and target tracking using sensor arrays. The idea is to use the prior knowledge to enhance certain desired properties ....Spectral analysis with selective harmonic emphasis. This project lies under ARC research priority area "Frontier Technologies for Building and Transforming Australian Industries". The signal processing algorithms to be developed in this project will be useful in many important practical applications, which include various bio-medical imaging modalities, beamforming, radar, sonar and target tracking using sensor arrays. The idea is to use the prior knowledge to enhance certain desired properties of the algorithms via intelligent processing. In this light the project also lies within the ARC research priority area of "Smart Information use".Read moreRead less
Developing vehicle-based advanced warning countermeasures for driver fatigue. Driver fatigue is a major problem in Australia in terms of health, road safety and economic impact. Countermeasures to combat the influence of driver fatigue have been limited to public campaign strategies like resting every 2 hours. There has been little robust research on developing on-road countermeasures that could warn the driver of their fatigue status. This proposed project involves a collaboration with Compumed ....Developing vehicle-based advanced warning countermeasures for driver fatigue. Driver fatigue is a major problem in Australia in terms of health, road safety and economic impact. Countermeasures to combat the influence of driver fatigue have been limited to public campaign strategies like resting every 2 hours. There has been little robust research on developing on-road countermeasures that could warn the driver of their fatigue status. This proposed project involves a collaboration with Compumedics Ltd, a leading medical device company, to conduct sophisticated research into developing an EEG and wheel behaviour fatigue countermeausure. We will further explore EEG and wheel behaviour patterns associated with fatigue, investigate noise control strategies, and conduct laboratory and on road field trials of the fatigue monitor. If this device is able to assess fatigue reliably and warn drivers in sufficient time to avert accidents, then substantial economic and social benefits will occur.Read moreRead less