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This project is about the way that the brain controls reproduction. It is important because there is no known cause for infertility in a significant number people with such a problem. The project should inform us on new ways to manage particular forms of reproductive failure.
Gonadotropin Inhibitory Hormone (GnIH); A Negative Regulator Of Reproduction
Funder
National Health and Medical Research Council
Funding Amount
$752,936.00
Summary
Gonadotropin inhibitory hormone (GnIH) is a short peptide of 8 amino acids that is produced by the brain and acts in a negative manner on brain and pituitary cells that control reproduction. This project aims to elucidate the role of GnIH in normal physiology and in states of stress and negative metabolic state. Work will be carried out in various species to define the function of the peptide and also to investigate ways that it can be utilised to prevent reproduction.
Hormonal Regulation Of Reproduction In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$7,580,681.00
Summary
Achieving the goal of reproductive health for all is a public health issue and is limited by factors including, problems of infertility, inadequacies of the fertility-regulating methods and the high incidence of reproductive tract diseases, including cancers. The overall objective of this Program Grant is to discover, understand and apply new knowledge about reproductive processes in health and disease to alleviating infertility, improving contraceptive choice and efficacy and combating diseases ....Achieving the goal of reproductive health for all is a public health issue and is limited by factors including, problems of infertility, inadequacies of the fertility-regulating methods and the high incidence of reproductive tract diseases, including cancers. The overall objective of this Program Grant is to discover, understand and apply new knowledge about reproductive processes in health and disease to alleviating infertility, improving contraceptive choice and efficacy and combating diseases in the reproductive organs.Read moreRead less
Neuroendocrine Mechanisms By Which Leptin Regulates Reproduction
Funder
National Health and Medical Research Council
Funding Amount
$447,750.00
Summary
The reproductive system is sensitive to alterations in body weight. In particular, low body weight causes the reproductive system to cease functioning. This is because the brain 'senses' metabolic status and responds by ceasing to secrete the brain hormone that drives the reproductive process. This hormone is gonadotropin releasing hormone that acts on the pituitary gland to control the release of gonadotropins. These, in turn, act on the gonads. How the brain perceives metabolic status is not k ....The reproductive system is sensitive to alterations in body weight. In particular, low body weight causes the reproductive system to cease functioning. This is because the brain 'senses' metabolic status and responds by ceasing to secrete the brain hormone that drives the reproductive process. This hormone is gonadotropin releasing hormone that acts on the pituitary gland to control the release of gonadotropins. These, in turn, act on the gonads. How the brain perceives metabolic status is not known. Leptin is a hormone that is produced by fat and acts on the brain. This appears to be one of the means by which the reproductive system is regulated. Leptin also regulates food intake and other brain processes. Leptin acts on specific cell types in the brain. Some of these may have dual function to regulated appetite as well as reproduction. The present proposal is for work to determine mechanisms within the brain that are altered by leptin. We will also determine which specific mechanisms relate to the regulation of gonadotropin releasing hormone. The work will provide information on how putative appetite regulators might affect the reproductive axis. Such work will provide a platform for design of pharmaceutical means to manipulate the reproductive axis and will impact on the design of drugs that regulate obesity. It is possible that drugs that developed to control obesity may affect the reproductive axis and the project will identify these.Read moreRead less