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Early Antipsychotic Exposure During Childhood And Adolescence: Does It Lead To Long Term Brain And Behaviour Changes In Adulthood?
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Mental health problems affect at least 9% of Australia's 4.1 million children. With the trend towards prescribing antipsychotic medication “off-label” to control these mental disorders in young people and the long-term consequences of doing so unknown, this timely research program aims to address a critical health issue by providing clinicians with valuable information so they can better balance the risk/benefit ratio before prescribing antipsychotics to young people.
Analysis Of The Apoptotic And Therapeutic Effects Of Histone Deacetylase Inhibitors On Multiple Myeloma
Funder
National Health and Medical Research Council
Funding Amount
$287,321.00
Summary
Multiple myeloma (MM) is an incurable progressive cancer of plasma cells within blood. It is the second most common blood cancer and represents 2% of all cancer-related deaths. Statistics show increasing incidence and decreasing age of onset. The cause and progression of MM is poorly understood and current treatments are frequently followed by relapse. This project will assess exciting new therapies against the survival of MM cells leading to more effective treatments in the future.
Viral Infection And Transforming Growth Factor-beta Impair Glucocorticoid Activity In Epithelial Cells
Funder
National Health and Medical Research Council
Funding Amount
$318,299.00
Summary
Anti-inflammatory types of steroid drugs are commonly used in chronic lung disease including asthma and chronic obstructive pulmonary disease. However, a significant number of sufferers show resistance to the steroid therapy. Our study is developing an understanding of how inflammation limits the anti-inflammatory effects of steroids and we are identifying novel therapeutic targets to improve the effectiveness of treatment of chronic disease.
Interventions To Improve Outcomes For Young Aboriginal And Torres Strait Islander People In Sexually Transmissible Infections Blood Borne Viruses And For People Using Methamphetamines
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This ECF will enable research to be carried out in the domains of sexually transmissible infections (STI) and blood borne viruses (BBV) and specifically methamphetamine (MA) use in Aboriginal communities nationally. Specific research outcomes will be the establishment of an Aboriginal primary health care and behavioural surveillance network for STIs/BBVs in nationally dispersed clinical hubs (CRE), and an improved understanding of interventions to address MA in Aboriginal communities.