A Novel Portable System For Day And Night Closed Loop Automated Insulin Delivery In The Patient With Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$251,133.00
Summary
For patients with Type 1 Diabetes, improved glucose control has been shown to reduce the development of diabetes complications. Although advances have been made in therapy, most people with diabetes do not achieve optimal treatment targets and the burden of care is high. Technologies now exist that allow the development of automatic insulin therapy and the artificial pancreas. These experiments will test a novel portable system that represents a significant step advancing toward this goal.
Glycaemia-increasing Effects Of Sprinting In Type 1 Diabetes: Toward The Validation Of New Clinical Guidelines For Hypoglycaemia Prevention
Funder
National Health and Medical Research Council
Funding Amount
$600,323.00
Summary
Recently, we found that the risk of hypoglycaemia associated with moderate intensity exercise in type 1 diabetic individuals is opposed by one or several short sprints performed during or after exercise. Our goal is to examine if exercising several hours before sprinting decreases its protective effect, and whether sprinting may impair several hours later the counterregulatory responses to hypoglycaemia. Finally, we will determine if guidelines advocating the use of short sprints reduce the risk ....Recently, we found that the risk of hypoglycaemia associated with moderate intensity exercise in type 1 diabetic individuals is opposed by one or several short sprints performed during or after exercise. Our goal is to examine if exercising several hours before sprinting decreases its protective effect, and whether sprinting may impair several hours later the counterregulatory responses to hypoglycaemia. Finally, we will determine if guidelines advocating the use of short sprints reduce the risk of hypoglycaemia under free living conditions.Read moreRead less
Diabetes Case Detection Through Emergency Department Admissions
Funder
National Health and Medical Research Council
Funding Amount
$162,896.00
Summary
This study aims to determine if the routine measurement of blood glucose among people admitted to hospital through Emergency can be an effective means of identifying people with potential diabetes.
Proactive Specialist Diabetes Inpatient Team To Improve Outcomes In Hospitalised Patients With Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$124,761.00
Summary
Diabetes is a major epidemic in Australia. Current care of hospitalised patients with diabetes is complex, suboptimal and contributes to longer hospital stay, poor outcomes and strain on healthcare resources. This research aims to improve diabetes care in hospitalised patients by implementing a proactive specialist diabetes team that will autonomously identify and provide specialist care for these patients. The expected findings have potential to shape a new approach to hospital diabetes care.
Post-stroke Hyperglycaemia – Treatment With Exenatide In Acute Ischaemic Stroke (TEXAIS) Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,266,149.00
Summary
Raised blood glucose levels (hyperglycaemia) after a stroke is common. It reduces the efficacy of stroke treatments and results in worse outcomes. Insulin is not useful as a treatment for this as it causes frequent hypoglycaemia and does not improve clinical outcomes. Exenatide is a common diabetes drug that is simple to use and lowers blood glucose without hypoglycaemia. It will be tested in the Treatment with Exenatide in Acute Ischaemic Stroke (TEXAIS) trial.
Treating Hyperglycaemia In Diabetes With Polyunsaturated Fatty Acid Analogues
Funder
National Health and Medical Research Council
Funding Amount
$602,260.00
Summary
Diabetes, characterised by elevated blood glucose, has a major impact on affected children, their families and the community. Our preliminary evidence suggests that a newly developed polyunsaturated fatty acid normalises blood glucose levels in an experimental diabetes model. This research will attempt to provide evidence that we have discovered a fat which has insulin like action and which may be taken orally once every 3-4 days to treat the elevated blood glucose.
Stress Hyperglycaemia And Mortality In Critical Illness: Defining The Association And Underlying Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$125,526.00
Summary
The relationship between high blood sugar levels (hyperglycaemia) and mortality in critically ill patients remains an area of controversy with conflicting results between studies. This PhD thesis will attempt to resolve this by firstly evaluating whether relative hyperglycaemia as measured using a novel new measure better predicts mortality outcome in such patients; and secondly, attempt to establish possible mechanisms which contributes to this.