How Does The Mitochondria Regulate Cardiac L-type Ca2+ Channel Function?
Funder
National Health and Medical Research Council
Funding Amount
$328,267.00
Summary
Oxygen is vital to cellular metabolism and function. Oxygen delivery to cells is critical and a lack of oxygen such as occurs during a heart attack can be lethal. The L-type Ca2+ channel is a protein in the membrane of heart muscle cells responsible for regulating the entry of calcium into heart muscle cells. It plays a role in maintaining the heart beat and contraction. We have found that a lack of oxygen (hypoxia) alters the function of the L-type Ca2+ channel and its response to adrenergic st ....Oxygen is vital to cellular metabolism and function. Oxygen delivery to cells is critical and a lack of oxygen such as occurs during a heart attack can be lethal. The L-type Ca2+ channel is a protein in the membrane of heart muscle cells responsible for regulating the entry of calcium into heart muscle cells. It plays a role in maintaining the heart beat and contraction. We have found that a lack of oxygen (hypoxia) alters the function of the L-type Ca2+ channel and its response to adrenergic stimulation (adrenaline).This may be one of the ways that rhythm disturbances or sudden cardiac death occurs with a heart attack. The activity of the L-type Ca2+ channel is sensitive to changes in reactive oxygen species caused by changes in oxygen concentration. The reactive oxygen species are generated from a part of the cell responsible for maintaining the cell's energy requirements (the mitochondria). Oxidative stress is a feature of various cardiovascular pathologies and we are now interested in determining the effect of oxidative stress on function of the L-type Ca2+ channel and the role of the mitochondria in generating reactive oxygen species. Oxidative stress can damage mitochondria leading to an increase in production of reactive oxygen species. We will determine how oxidative stress damages the mitochondria and how this then alters the channel function, directly or indirectly. The information gained will provide insight into how reactive oxygen species influence L-type Ca2+ channel function and the mechanisms that contribute to pathology involving reactive oxygen species such as heart failure and arrhythmia.Read moreRead less
Redox Control Of The Immune Regulatory Protein, Indoleamine 2,3-dioxygenase
Funder
National Health and Medical Research Council
Funding Amount
$576,538.00
Summary
An enzyme called indoleamine 2,3-dioxygenase is important for controlling the immune system during normal and disease conditions including pregnancy, cancer, inflammation and infectious disease. Despite its importance little is known about how this enzyme is controlled. This project will provide important new insights into how this enzyme is regulated. Such fundamental scientific information can discover new ways in which to alter the enzyme's activity in order to modulate immune responses.
Structural safety guidelines for accidental hydrogen explosion hazards . This project aims to develop structural safety guidelines to mitigate hydrogen explosion hazards which can be identified as a major safety concern due to the higher demand worldwide for sustainable energy sources with no carbon emission. The world’s growing demand for hydrogen and Australia’s National Hydrogen Strategy to develop the industry will make Australia a core player in hydrogen production creating a massive econom ....Structural safety guidelines for accidental hydrogen explosion hazards . This project aims to develop structural safety guidelines to mitigate hydrogen explosion hazards which can be identified as a major safety concern due to the higher demand worldwide for sustainable energy sources with no carbon emission. The world’s growing demand for hydrogen and Australia’s National Hydrogen Strategy to develop the industry will make Australia a core player in hydrogen production creating a massive economic opportunity. However, the high flammability and low ignition energy of hydrogen makes it vulnerable to accidental explosions. Hence, this project will address the lack of safety protocols in Australian Standards related to the handling of hydrogen by producing essential design recommendations.Read moreRead less
Embrittlement-tolerant alloys for safe hydrogen transmission and storage. Hydrogen embrittlement in steels is a major impediment to a safe hydrogen economy. This project will determine how hydrogen affects the deformation behaviour of steel, providing the fundamental information that is required to develop alloys that can be safely used in infrastructure for a future Australian hydrogen industry. We will utilise new technologies that allow us, for the first time, to determine the position of hyd ....Embrittlement-tolerant alloys for safe hydrogen transmission and storage. Hydrogen embrittlement in steels is a major impediment to a safe hydrogen economy. This project will determine how hydrogen affects the deformation behaviour of steel, providing the fundamental information that is required to develop alloys that can be safely used in infrastructure for a future Australian hydrogen industry. We will utilise new technologies that allow us, for the first time, to determine the position of hydrogen atoms around micro-scale features and to compare it to local mechanical behaviour, determined by micro-mechanical tests. The systematic investigation of the effect of hydrogen on different micro-components within steel will allow the development of microstructure-guided alloy design principles.Read moreRead less
Bulk Mg based hydrogen storage alloys with faster activation. Bulk Mg based hydrogen storage alloys with faster activation. This project aims to improve the performance and efficiency of manufacture of magnesium-based hydrogen storage alloys, making them more cost competitive and widely useable. A hydrogen economy will reduce greenhouse gas emissions and improve air quality in urban areas. The expected outcomes are an understanding of the mechanisms governing the activation process, a necessary ....Bulk Mg based hydrogen storage alloys with faster activation. Bulk Mg based hydrogen storage alloys with faster activation. This project aims to improve the performance and efficiency of manufacture of magnesium-based hydrogen storage alloys, making them more cost competitive and widely useable. A hydrogen economy will reduce greenhouse gas emissions and improve air quality in urban areas. The expected outcomes are an understanding of the mechanisms governing the activation process, a necessary step in manufacture, and techniques to exploit these mechanisms to minimise the activation time. This is expected to develop competitive, bulk magnesium-based hydrogen storage alloys for effective and safe hydrogen storage systems.Read moreRead less
Mesoporous Metal Scaffolds: Reactive Containment Vessels. The storage of hydrogen is one of the most important issues that remains to be solved before the mass implementation of hydrogen as an energy carrier becomes commercially viable. This project aims to determine the kinetic and thermodynamic benefits of mesoporous metal scaffolds as reactive containment vessels for hydrogen storage materials. Fundamental experimental research into the synthesis, characterisation, and modification of nano-co ....Mesoporous Metal Scaffolds: Reactive Containment Vessels. The storage of hydrogen is one of the most important issues that remains to be solved before the mass implementation of hydrogen as an energy carrier becomes commercially viable. This project aims to determine the kinetic and thermodynamic benefits of mesoporous metal scaffolds as reactive containment vessels for hydrogen storage materials. Fundamental experimental research into the synthesis, characterisation, and modification of nano-confined hydrogen storage materials will be carried out. The results of this research are expected be used to tune hydrogen desorption temperatures and pressures of various light weight hydrogen storage materials to generate new materials attractive to the automobile industry.Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100160
Funder
Australian Research Council
Funding Amount
$477,237.00
Summary
Characterise high-performance, green steels for the hydrogen economy. This project aims to develop the knowledge around microstructures and hydrogen interactions of a range of advanced steels that can be produced with low carbon emissions by the industry partner. These steels can lead to solutions for the hydrogen pipes and vessels without concern of hydrogen embrittlement, which play a crucial role in enabling a safe hydrogen economy in Australia. This partnership will allow the industry partne ....Characterise high-performance, green steels for the hydrogen economy. This project aims to develop the knowledge around microstructures and hydrogen interactions of a range of advanced steels that can be produced with low carbon emissions by the industry partner. These steels can lead to solutions for the hydrogen pipes and vessels without concern of hydrogen embrittlement, which play a crucial role in enabling a safe hydrogen economy in Australia. This partnership will allow the industry partner to access the advanced characterisation tools and will also expose the Fellow with the opportunity to develop and manufacture new steels in industry. This will also de-risk the KIP’s investment in Australia for a new steel mill dedicating to the new green steels for supporting Australia’s hydrogen infrastructure.Read moreRead less
Modification of optical properties of photocatalytic titania. The aim of the project is to capitalise on and optimise the recently discovered successful modification of the optical properties of titanium oxide (TiO2), such that efficient solar splitting of water is possible. TiO2 photocatalysts of adequate efficiency will be implemented as photoanodes in photoelectrochemical cells capable of large-scale production of hydrogen.
Industry Laureate Fellowships - Grant ID: IL230100173
Funder
Australian Research Council
Funding Amount
$3,689,641.00
Summary
Accelerating Green Hydrogen Production with High Efficiency Electrolysers. This project aims to accelerate the decarbonisation of high-carbon industries (eg heavy transport, chemical production, and steel) by advancing the manufacture of high efficiency water electrolysers in Australia. Innovative electrochemical and other techniques that exploit all of the levers for high efficiency in electrolysers, will be applied to support the commercial development of this key component of green hydrogen p ....Accelerating Green Hydrogen Production with High Efficiency Electrolysers. This project aims to accelerate the decarbonisation of high-carbon industries (eg heavy transport, chemical production, and steel) by advancing the manufacture of high efficiency water electrolysers in Australia. Innovative electrochemical and other techniques that exploit all of the levers for high efficiency in electrolysers, will be applied to support the commercial development of this key component of green hydrogen production. Expected outcomes of this project, in collaboration with industry partner Hysata, include a low-cost, simplified design, and ultra-high energy efficiency. This should provide significant benefits to the green hydrogen sector, industry, and contribute to achieving net-zero emissions globally.Read moreRead less