Risk Factors For Long-term Chronic Disease Events In HIV-positive Persons: The D:A:D Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$925,659.00
Summary
The D:A:D Study is a large, international study assessing risk factors for chronic disease events in HIV-positive patients. We know these events, such as heart attacks and cancers, increase with age. And we also know that these events are more common in HIV-positive people. Over the next five years, D:A:D will assess risk factors for chronic disease events in HIV-positive people as they age, and help optimise patient monitoring and management.
HIV Treatment As Prevention: A Longitudinal Assessment Of Population Effectiveness
Funder
National Health and Medical Research Council
Funding Amount
$783,160.00
Summary
This project is a large-scale evaluation of an HIV strategy known as ‘treatment as prevention’ (TasP). Through routine and repeat HIV testing for gay men and early treatment initiation following diagnosis, TasP aims to reduce HIV community infection rates. Through the establishment of a large cohort of gay men in NSW and Victoria, this study will track HIV testing, treatment and management to assess the real-world efficacy of TasP for reducing HIV infections among this at-risk population.
Randomised Controlled Trial Of HPV Self-sampling For Improving Participation In Cervical Screening: The IPAP Trial
Funder
National Health and Medical Research Council
Funding Amount
$534,461.00
Summary
Effectiveness of cervical cancer screening relies on maximising participation. Unlike a Pap test, an HPV test may be self-collected and this may overcome some of the barriers to Pap testing. Overseas trials have found higher uptake for HPV self-sampling (between 3-30%) compared with Pap test reminder letters. We will conduct the first randomised trial in Australia comparing home-based HPV self-sampling with a reminder letter, to evaluate whether this improves participation and followup.
Viral Load, HIV Treatment, And HIV Transmission In Serodiscordant Male Homosexual Couples
Funder
National Health and Medical Research Council
Funding Amount
$1,452,298.00
Summary
HIV treatment reduces the concentration of HIV in the body. In heterosexuals, current studies will determine the effectiveness of HIV treatment in preventing onwards HIV transmission. In contrast, there has been very little such research in homosexual men, who comprise 70% or more of people with HIV in Australia. This study will follow for four years over 200 male homosexual couples in which one is HIV positive and the other negative, to investigate the role of HIV treatment in HIV prevention.
Evaluation Of Outcomes And Cost-effectiveness Of Implementing Next Generation Human Papillomavirus (HPV) Vaccination And Associated Primary HPV-based Cervical Cancer Screening Strategies In Australia
Funder
National Health and Medical Research Council
Funding Amount
$697,071.00
Summary
This project involves using simulation modelling to predict the effect of the next generation human papillomavirus (HPV) vaccine, which will protect against infection with more strains of HPV. The investigators will use large datasets garnered from around the world to inform the assessment of the cost-effectiveness of this new vaccine in Australia and other key countries, and also to assess whether cervical screening will need to change in the future to account for the introduction of the new va ....This project involves using simulation modelling to predict the effect of the next generation human papillomavirus (HPV) vaccine, which will protect against infection with more strains of HPV. The investigators will use large datasets garnered from around the world to inform the assessment of the cost-effectiveness of this new vaccine in Australia and other key countries, and also to assess whether cervical screening will need to change in the future to account for the introduction of the new vaccine.Read moreRead less
Developing A System For Comprehensive Quantitative Evaluation Of Public Health Strategies Against HIV/AIDS In Australia: Assessing The Past, Understanding The Present And Planning For The Future
Funder
National Health and Medical Research Council
Funding Amount
$407,358.00
Summary
The overall goal of this project is to develop and implement a system which will make optimal use of all available data on HIV/AIDS from different sources in Australia, uniquely integrate the data routinely into an innovative evaluation framework which will be developed using best modelling and economic practices, and conduct analyses which will improve the effectiveness and efficiency of Australia’s HIV policy and program response to prevent new infections and plan for clinical care required fo ....The overall goal of this project is to develop and implement a system which will make optimal use of all available data on HIV/AIDS from different sources in Australia, uniquely integrate the data routinely into an innovative evaluation framework which will be developed using best modelling and economic practices, and conduct analyses which will improve the effectiveness and efficiency of Australia’s HIV policy and program response to prevent new infections and plan for clinical care required for people living with HIV.Read moreRead less
Improving Antiretroviral Treatment (ART) Initiation For People Living With HIV In Australia: A Realistic And Feasible Approach?
Funder
National Health and Medical Research Council
Funding Amount
$434,722.00
Summary
Antiretroviral treatment (ART) has improved the lives of people living with HIV (PLHIV). This study will investigate barriers, incentives and reasons that influence decision making of PLHIV and clinicians regarding whether to start ART and when. The study will examine the potential public health impact of promoting ART use on the HIV epidemic. The study will make significant contributions to improvement of ART use and advances in HIV prevention.