How Does Dietary Cholesterol Induce Non-alcoholic Steatohepatitis?
Funder
National Health and Medical Research Council
Funding Amount
$802,600.00
Summary
Non-alcoholic fatty liver disease is the most common liver disease that can progress to non-alcoholic steatohepatitis (NASH), cirrhosis and liver cancer. Dietary cholesterol is a major risk factor for NASH. We can demonstrate that cholesterol changes the gut bacteria. These bacteria generate toxic chemicals (bile acids) that signal to the liver and induce NASH. In this project, we use novel ways to clarify the mechanisms of liver inflammation and test novel therapeutic approaches to reverse it.
Hepatitis C affects a quarter of a million Australians, causing insidious but progressive liver disease which culminates in liver failure or cancer. There is no vaccine and prevention programs have limited effectiveness, but new antiviral therapies now offer high rates of cure. This Program will evaluate strategies to improve the health of those affected and prevent new infections by better understanding of the virus and the body’s immune response, including scarring and liver cancer formation.
Imaging The Hepatitis C Virus Life Cycle In Real-time
Funder
National Health and Medical Research Council
Funding Amount
$477,504.00
Summary
Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may unco ....Hepatitis C virus (HCV) is a serious viral pathogen that causes significant liver disease. This proposal plans to examine how two proteins from the HCV, core and NS5A, interact with host proteins and pathways to facilitate viral replication and release of HCV; two processes that are poorly understood. Specifically we will tag viral proteins to allow us to investigate the HCV life cycle in living cells and determine the role of core and NS5A in facilitating HCV replication. This proposal may uncover novel therapeutic strategies to combat HCV.Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Improving the health and wellbeing of poorly housed Australians: understanding and responding to multiple housing deficit. Australia is currently in a housing crisis, with many escalating problems, including poor affordability, chronic undersupply, homelessness, insecurity in the private rental market and a shrinking public housing sector. While some Australians are unaffected, increasing numbers of already vulnerable people experience multiple housing problems. This project aims to develop a ne ....Improving the health and wellbeing of poorly housed Australians: understanding and responding to multiple housing deficit. Australia is currently in a housing crisis, with many escalating problems, including poor affordability, chronic undersupply, homelessness, insecurity in the private rental market and a shrinking public housing sector. While some Australians are unaffected, increasing numbers of already vulnerable people experience multiple housing problems. This project aims to develop a new theoretical framework for focusing on Australians who experience multiple housing problems. It aims to identify who will be affected, how this will play out on individual health and wellbeing, and how governments can best respond. It will provide essential evidence and intervention tools for understanding and improving the lives of the most vulnerable.Read moreRead less
Pathways for Indigenous and Western knowledge into Environmental Policy. The aim of this project is to identify the ways in which all knowledge, particularly Western and Indigenous knowledges can work together to inform environmental policy, with a focus on climate change adaptation. Using participatory methodologies and supported by an Indigenous led advisory group, the project will partner with Indigenous Ranger groups to interrogate three key knowledge management concepts: integration, co-pro ....Pathways for Indigenous and Western knowledge into Environmental Policy. The aim of this project is to identify the ways in which all knowledge, particularly Western and Indigenous knowledges can work together to inform environmental policy, with a focus on climate change adaptation. Using participatory methodologies and supported by an Indigenous led advisory group, the project will partner with Indigenous Ranger groups to interrogate three key knowledge management concepts: integration, co-production and co-existence. Based on communities of practice, in the Kati Thanda-Lake Eyre Basin, Australia, the Fellowship seeks to produce mechanisms of knowledge co-existence and maintenance that will contribute to stronger environmental policies and create spaces for Indigenous voices to be represented within them.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Pathways to health and wellbeing through housing: a new causal understanding of relationships, processes and interventions. Does housing make Australians healthier or less healthy, how can we target housing assistance so that it improves individual health and wellbeing? This research answers these questions, it develops new methods for understanding the complex causal relationship between housing and health, and evidence of how housing can improve health and wellbeing.
Closing the housing gap: a spotlight on intergenerational inequalities. This project aims to use never-before analysed combinations of datasets and new data on Australian housing conditions to model the consequences of unequal access to housing and housing wealth among Australians, and to evaluate both individual and national benefits of housing interventions across generations. The consequences of unequal access to housing are different for current and future generational cohorts. This project ....Closing the housing gap: a spotlight on intergenerational inequalities. This project aims to use never-before analysed combinations of datasets and new data on Australian housing conditions to model the consequences of unequal access to housing and housing wealth among Australians, and to evaluate both individual and national benefits of housing interventions across generations. The consequences of unequal access to housing are different for current and future generational cohorts. This project expects to reveal the drivers and health consequences of the intergenerational housing gap. Research-based insights on the intergenerational housing crisis will benefit almost all Australians affected by the unprecedented costs of ownership and renting.Read moreRead less