Arbovirus Activation And Modulation Of NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$779,720.00
Summary
This project aims to establish how mosquito borne viruses such as Ross River and dengue viruses interacts with the human host to cause disease, including how the virus evades the host’s immune response to persist and cause disease for prolonged periods. Knowing how differences in the virus and the host’s immune system interplay to cause asymptomatic to severely disabling disease will assist in devising new treatments and prevention programs to lessen the impact of these diseases in Australia.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Fundamentals and applications of continuous-flow microprocessing systems based on supercritical fluids and gas expanded liquids. Microchemical systems have considerable potential in the area of chemical discovery and development. Practical application of these systems requires fundamental understanding and strategies for conversion to appropriate scale. The aim of this project is to overcome such challenges in the development of microstructured continuous-flow technology.
Nutrition insecurity and livelihood decision-making in rural Myanmar. Global progress against malnutrition has been too slow to allow the Millennium Development Goals on hunger to be met. International research has proposed that these failures are due to the fact that the livelihood options available to poor households are increasingly misaligned from their traditional channels for ensuring food and nutrition security. This argument is highly influential in international development research, un ....Nutrition insecurity and livelihood decision-making in rural Myanmar. Global progress against malnutrition has been too slow to allow the Millennium Development Goals on hunger to be met. International research has proposed that these failures are due to the fact that the livelihood options available to poor households are increasingly misaligned from their traditional channels for ensuring food and nutrition security. This argument is highly influential in international development research, underpinning calls for nutrition-sensitive development interventions. The aim of this project is to test the proposition using original survey data collected from 1 600 households in rural Myanmar. This will be the first project of this kind, aiming to shed crucial insight into this issue at this vital moment in Myanmar's transition.Read moreRead less
Evolutionary Dynamics and the Transformation of Rural Australia. Understanding the ways in which Australia's rural heartland has been transformed is critical to constructing competitive regions. This project aims to pioneer the application and development of evolutionary economic geography and staples theory to an investigation of the transformation of south-east and south-western Australia, covering the long boom of the post-war period, through the restructuring 'crisis' of the 1980s and 1990s, ....Evolutionary Dynamics and the Transformation of Rural Australia. Understanding the ways in which Australia's rural heartland has been transformed is critical to constructing competitive regions. This project aims to pioneer the application and development of evolutionary economic geography and staples theory to an investigation of the transformation of south-east and south-western Australia, covering the long boom of the post-war period, through the restructuring 'crisis' of the 1980s and 1990s, to a multifunctional countryside. The explanatory power of the local modelling 'tools' that this project is expected to develop moves beyond the 'one size fits all' suite of policy prescriptions, with the specific potential to inform rural and regional policy and practice.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100164
Funder
Australian Research Council
Funding Amount
$310,000.00
Summary
A facility for ex-vivo molecular imaging. The facility will allow a consortium of Australian researchers to create an integrated facility for imaging biological receptors in tissue, bringing together laboratory, radiochemistry and imaging expertise. Digital data at each site will be able to be viewed and analysed remotely.