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Unveiling the epigenome dynamics through the pluripotency continuum. This project aims to utilise stem cells and genomics based technologies, in combination with new computational algorithms to dissect the fundamental molecular events that drive the first steps during development. The project is expected to unveil the basic mechanisms underpinning how genes driving the developmental master plan are controlled in cells that have the capacity to give rise to the whole organism and placenta. The kn ....Unveiling the epigenome dynamics through the pluripotency continuum. This project aims to utilise stem cells and genomics based technologies, in combination with new computational algorithms to dissect the fundamental molecular events that drive the first steps during development. The project is expected to unveil the basic mechanisms underpinning how genes driving the developmental master plan are controlled in cells that have the capacity to give rise to the whole organism and placenta. The knowledge gained from this work will inform and guide future novel approaches, such as in assisted reproductive technologies or regenerative medicine.Read moreRead less
Metabolic control of organ growth and regeneration. One of the fundamental questions in biology is to understand how organ size is regulated at the cellular and organismal level. The Hippo/Yap pathway plays a central role in the regulation of organ size and it is impacted by environmental cues including nutrient status. This research proposal aims to use zebrafish to elucidate the role that the Hippo/Yap pathway plays in reprogramming lipid metabolism to fuel tissue growth in development and reg ....Metabolic control of organ growth and regeneration. One of the fundamental questions in biology is to understand how organ size is regulated at the cellular and organismal level. The Hippo/Yap pathway plays a central role in the regulation of organ size and it is impacted by environmental cues including nutrient status. This research proposal aims to use zebrafish to elucidate the role that the Hippo/Yap pathway plays in reprogramming lipid metabolism to fuel tissue growth in development and regeneration. Ultimately, this work aims to identify metabolic dependencies required for organ growth and regeneration. Expected outcomes include scholarly publications revealing fundamental principles underlying tissue growth, new resources for the research community and training for research students.Read moreRead less
Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specif ....Redefining tissue-specific endothelial cells through bioengineered matrices. This project aims to improve our understanding of the biological mechanisms that drive blood vessel formation and function. The endothelial cells that make up each blood vessel are inherently unique across different sites within the human body and this project expects to generate new knowledge regarding their organ specificity. Using advanced bioengineering approaches, this project will map human endothelial cell specificity and develop state-of-the-art modelling technologies to improve knowledge of environmental influence on endothelial cell fate and function. This should provide a new framework to modulate the adaptive capacities of endothelial cells and can potentially enable more predictive and targeted drug efficacy and safety testing.Read moreRead less
Improving the health and wellbeing of poorly housed Australians: understanding and responding to multiple housing deficit. Australia is currently in a housing crisis, with many escalating problems, including poor affordability, chronic undersupply, homelessness, insecurity in the private rental market and a shrinking public housing sector. While some Australians are unaffected, increasing numbers of already vulnerable people experience multiple housing problems. This project aims to develop a ne ....Improving the health and wellbeing of poorly housed Australians: understanding and responding to multiple housing deficit. Australia is currently in a housing crisis, with many escalating problems, including poor affordability, chronic undersupply, homelessness, insecurity in the private rental market and a shrinking public housing sector. While some Australians are unaffected, increasing numbers of already vulnerable people experience multiple housing problems. This project aims to develop a new theoretical framework for focusing on Australians who experience multiple housing problems. It aims to identify who will be affected, how this will play out on individual health and wellbeing, and how governments can best respond. It will provide essential evidence and intervention tools for understanding and improving the lives of the most vulnerable.Read moreRead less
Unaffordable housing: impacts on socio-economic conditions and wellbeing . The project plans to explore how the current housing affordability crisis is shaping population wellbeing and socioeconomic outcomes. Housing affordability is a key driver of health-related inequalities – the dramatic rise in the cost of housing in the past decade is forcing people to make hard decisions about location and quality of housing. This project aims to provide a new framework for analysing housing affordability ....Unaffordable housing: impacts on socio-economic conditions and wellbeing . The project plans to explore how the current housing affordability crisis is shaping population wellbeing and socioeconomic outcomes. Housing affordability is a key driver of health-related inequalities – the dramatic rise in the cost of housing in the past decade is forcing people to make hard decisions about location and quality of housing. This project aims to provide a new framework for analysing housing affordability's long-term impact on wellbeing and socioeconomic outcomes by merging concepts from life course epidemiology on the importance of the timing, sequence and accumulation of exposure, to transition points at critical life stages from the social sciences. It plans to develop information to contribute to public discourse and improve policy in the area.Read moreRead less
Pathways for Indigenous and Western knowledge into Environmental Policy. The aim of this project is to identify the ways in which all knowledge, particularly Western and Indigenous knowledges can work together to inform environmental policy, with a focus on climate change adaptation. Using participatory methodologies and supported by an Indigenous led advisory group, the project will partner with Indigenous Ranger groups to interrogate three key knowledge management concepts: integration, co-pro ....Pathways for Indigenous and Western knowledge into Environmental Policy. The aim of this project is to identify the ways in which all knowledge, particularly Western and Indigenous knowledges can work together to inform environmental policy, with a focus on climate change adaptation. Using participatory methodologies and supported by an Indigenous led advisory group, the project will partner with Indigenous Ranger groups to interrogate three key knowledge management concepts: integration, co-production and co-existence. Based on communities of practice, in the Kati Thanda-Lake Eyre Basin, Australia, the Fellowship seeks to produce mechanisms of knowledge co-existence and maintenance that will contribute to stronger environmental policies and create spaces for Indigenous voices to be represented within them.Read moreRead less
Conserving Carbon in the Extractive Frontiers of Insular Southeast Asia: Risks or Opportunities? Increasingly global climate change governance uses market-based mechanisms to offer forest users financial incentives to maintain forest carbon in the frontiers of Southeast Asia. At the same time, these forest landscapes are rapidly being converted for ‘boom crop’ production such as oil palm and rubber. However, little is known about how carbon governance intersects with such monocropping to affect ....Conserving Carbon in the Extractive Frontiers of Insular Southeast Asia: Risks or Opportunities? Increasingly global climate change governance uses market-based mechanisms to offer forest users financial incentives to maintain forest carbon in the frontiers of Southeast Asia. At the same time, these forest landscapes are rapidly being converted for ‘boom crop’ production such as oil palm and rubber. However, little is known about how carbon governance intersects with such monocropping to affect local livelihoods, property rights and social relations. This project examines how the global market-driven approach, REDD+ (Reduced Emissions from Environmental Degradation and Deforestation+), governs forest carbon vis-à-vis commodity production, how this impacts rural livelihoods, and influences the viability of climate change governance. Read moreRead less
Coastal governance. This project aims to discover coastal governance approaches that embrace vulnerability and change. Current coastal management approaches are failing as existing threats intensify and new threats emerge. This project expects to generate knowledge on diverse vulnerabilities, with insights advancing the disciplines of human geography and public policy through improved understanding of the relationships between people, place and change. This is expected to support ongoing economi ....Coastal governance. This project aims to discover coastal governance approaches that embrace vulnerability and change. Current coastal management approaches are failing as existing threats intensify and new threats emerge. This project expects to generate knowledge on diverse vulnerabilities, with insights advancing the disciplines of human geography and public policy through improved understanding of the relationships between people, place and change. This is expected to support ongoing economic, environmental, social and cultural benefits that are derived from the Australian coast.
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Providing children with a healthy start to life: promoting physical activity and reducing sedentary behaviours during early childhood. Early childhood (0-5 yrs), when health behaviours develop and may track into later life, represents promise as a time to positively impact physical activity and sedentary behaviour. Yet study of these behaviours in 3-5 yr olds is only emerging, and is almost non-existent in younger children. This project aims to understand predictors of these behaviours using a s ....Providing children with a healthy start to life: promoting physical activity and reducing sedentary behaviours during early childhood. Early childhood (0-5 yrs), when health behaviours develop and may track into later life, represents promise as a time to positively impact physical activity and sedentary behaviour. Yet study of these behaviours in 3-5 yr olds is only emerging, and is almost non-existent in younger children. This project aims to understand predictors of these behaviours using a suite of longitudinal studies, including objective measures, and will commence as early as 3-mths of age. It will study strategies for promoting physical activity and reducing sedentary behaviours during early childhood, by investigating mechanisms of behaviour change in existing interventions to inform new strategies with potential to provide children with a healthy start to life.Read moreRead less
Nanoparticle formulations for DNA-targeted radiotherapy and imaging: combinations with chromatin-modifying compounds. This project will develop a new approach for treating and imaging cancer using nanoparticles which target specific cells for cancer therapy and diagnostic imaging. The nanoparticles will be combined with compounds that alter the architecture of DNA to make therapy more effective and to improve the safety of imaging.