Role Of The Anaphase-Promoting Complex Activator Cdh1 In Oocyte Maturation And Meiotic Aneuploidy
Funder
National Health and Medical Research Council
Funding Amount
$526,878.00
Summary
Eggs containing an incorrect number of chromosomes are described as aneuploid. This project sets out to examine the molecular causes of aneuploidy and why it increases with female age. We focus on the protective role of the protein Cdh1 in this process. The outcome would be to better understand the origins of aneuploidy so as to find methods of decreasing it as women age. This is highly significant given aneuploidy is the leading cause of early embryo loss and produces Down Syndrome babies.
Defining The Molecular Effectors Of Gene/environment Interaction On Mouse Heart Development
Funder
National Health and Medical Research Council
Funding Amount
$749,271.00
Summary
One third of all birth defects involve the heart, and are the most common cause of infant death. Some defects are due to genetic factors, but others arise when the pregnant mother is exposed to environmental stress. We will examine how one stress (low oxygen levels) causes abnormal heart formation in the embryo, look at what causes this at a molecular level, and explore if such stress increases the risk of heart defects in families with a history of such abnormalities
Group A Streptococcal Human Challenge Study: Accelerating Vaccine Development
Funder
National Health and Medical Research Council
Funding Amount
$2,018,741.00
Summary
Infection with group A streptococcus (GAS) is a major cause of morbidity and mortality worldwide, including in the Aboriginal population of Australia. Concerted efforts for vaccine development have been hampered by the absence of a suitable animal model. To address this critical knowledge gap we propose to develop a controlled human infection model of GAS infection. This model will provide a direct pathway for the future appraisal of novel GAS vaccines.
Life, living and livelihoods in satellite cities: new urban forms in India . This project aims to assess the success of satellite cities, conceived as possible solutions to the urgent challenge of rapid urban growth in today’s megacities. Through an ethnography of an Indian satellite city, Mahindra World City, this project aims to generate knowledge on new urban formations and the consequences of experiments in urban development for different socio-economic groups. Understanding the lived experi ....Life, living and livelihoods in satellite cities: new urban forms in India . This project aims to assess the success of satellite cities, conceived as possible solutions to the urgent challenge of rapid urban growth in today’s megacities. Through an ethnography of an Indian satellite city, Mahindra World City, this project aims to generate knowledge on new urban formations and the consequences of experiments in urban development for different socio-economic groups. Understanding the lived experiences of residents/workers in satellite cities aims to form a robust evidence base for research driven dialogue with policy makers, planners and developers. Lessons derived are expected to inform policy and practice as to how to achieve wellbeing for urban residents, while providing indications of Asia’s urban futures.Read moreRead less
The changing geographies of power, knowledge and access in Australia's financial services sector: a regional development perspective. This project investigates one of the most pressing issues in the development of regional Australia: whether the modern financial services sector acts to reinforce or remediate existing patterns of uneven development. The research focuses on two key issues: 1) how the restructuring of the banking sector has affected the availability of financial services and ventur ....The changing geographies of power, knowledge and access in Australia's financial services sector: a regional development perspective. This project investigates one of the most pressing issues in the development of regional Australia: whether the modern financial services sector acts to reinforce or remediate existing patterns of uneven development. The research focuses on two key issues: 1) how the restructuring of the banking sector has affected the availability of financial services and venture capital in rural and urban Australia; and 2) the relationship between the changing geography of financial services and financial institutions' increasing reliance upon instrumental knowledge about their customers. The research will produce a model of the role of modern financial services provision and market knowledge in regional development.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170101060
Funder
Australian Research Council
Funding Amount
$323,000.00
Summary
Employer strategies for developing a skilled workforce. This project aims to discover why employers use particular strategies when sourcing skills and whether these strategies benefit their workers.Addressing employer skills needs expediently is imperative for productivity and national prosperity. Employers’ strategies have profound implications for the workforce and the Australian labour market, particularly at a time of rising unemployment. This project will study why employers increasingly ‘b ....Employer strategies for developing a skilled workforce. This project aims to discover why employers use particular strategies when sourcing skills and whether these strategies benefit their workers.Addressing employer skills needs expediently is imperative for productivity and national prosperity. Employers’ strategies have profound implications for the workforce and the Australian labour market, particularly at a time of rising unemployment. This project will study why employers increasingly ‘buy’ skills externally, through recruitment and sponsored immigration, rather than ‘build’ skills internally through employee development strategies. Understanding how immigration and domestic policy mechanisms addressing employer and labour market needs is expected to inform policy development on this vital issue.Read moreRead less
Developing And Implementing Systems To Optimise Treatment, Care And Support Among People Diagnosed With HIV
Funder
National Health and Medical Research Council
Funding Amount
$1,021,439.00
Summary
Immediate treatment of people diagnosed with HIV infection has become a key public health intervention, based on recent evidence confirming treatment suppresses the virus to undetectable levels, and effectively eliminates the risk of transmission to sexual partners. Our partnership will identify and address barriers to accessing specialist HIV care and starting treatment among people recently diagnosed with HIV, and will contribute to Australia’s goal of ending HIV transmission by 2020.
Seeking Asylum Alone: The Treatment of Separated and Trafficked Children in Need of Refugee Protection in Australia. Forced migration is a critical human rights issue. Although increasing in number, children traveling on their own to seek protection abroad have received scant scholarly attention. No systematic research exists on the efficacy of asylum as a mechanism for protecting separated children smuggled or trafficked into Australia. Claims and experiences of such children will be catalog ....Seeking Asylum Alone: The Treatment of Separated and Trafficked Children in Need of Refugee Protection in Australia. Forced migration is a critical human rights issue. Although increasing in number, children traveling on their own to seek protection abroad have received scant scholarly attention. No systematic research exists on the efficacy of asylum as a mechanism for protecting separated children smuggled or trafficked into Australia. Claims and experiences of such children will be catalogued and studied to determine the extent and nature of the disadvantage they face within Australia's refugee system. The findings will contribute to an international project aimed articulating best practice guidelines for the legal treatment of separated children in refugee determination systems around the world.Read moreRead less
Perceived Density, Social Interaction and Morale in Australian Rural Communities. The social viability of rural communities rests, to a greater or lesser degree, upon the density of the local settlement network, and residents' perceptions of it. This project will create a measure of perceived density (i.e. people's subjective interpretations of measured density) and will establish how it influences Australian rural residents' social interaction patterns and morale. The project will produce a con ....Perceived Density, Social Interaction and Morale in Australian Rural Communities. The social viability of rural communities rests, to a greater or lesser degree, upon the density of the local settlement network, and residents' perceptions of it. This project will create a measure of perceived density (i.e. people's subjective interpretations of measured density) and will establish how it influences Australian rural residents' social interaction patterns and morale. The project will produce a conceptually rigorous and concrete understanding of the density-related factors influencing rural community social viability and morale, and will aid rural communities in identifying and overcoming local social interaction constraints.Read moreRead less
Left Out and Missing Out: Towards New Indicators of Social Exclusion and Material Deprivation. This ground-breaking project will utilise academic knowledge and practical agency experience built up over decades to produce a new framework for identifying and measuring exclusion and deprivation in contemporary Australian society. It will generate new findings on public attitudes to the 'necessary requirements' needed to participate at all levels in society and the economy. It will examine the popul ....Left Out and Missing Out: Towards New Indicators of Social Exclusion and Material Deprivation. This ground-breaking project will utilise academic knowledge and practical agency experience built up over decades to produce a new framework for identifying and measuring exclusion and deprivation in contemporary Australian society. It will generate new findings on public attitudes to the 'necessary requirements' needed to participate at all levels in society and the economy. It will examine the population profile of the individuals and groups who are denied these opportunities, using both quantitative (survey) and qualitative (focus group) data, and its findings will complement existing data collections.Read moreRead less