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The proposal is to set-up a high-standard cell culture facility that will enable the establishment of a national repository of quality-controlled vertebrate cell lines derived from various tissues and species. This will facilitate high quality studies in a wide range of areas of basic health and medical research and in biotechnology.
Iron-Infection Interactions: Studies Of The Link Between Iron Metabolism And Infectious Diseases Of Global Significance
Funder
National Health and Medical Research Council
Funding Amount
$383,244.00
Summary
Anaemia, malaria and HIV affect millions of people worldwide, but interactions between these conditions are poorly understood. A haematologist with training in public health, my interest is in finding ways to control the enormous global burden of anaemia. My research will focus on how iron status influences infection with malaria and HIV. It will provide evidence for anaemia control guidelines and help improve global policies for controlling iron deficiency where these infections coexist.
Consuming Celebrity: Female stardom and gay subcultural reception. This project explores the function of celebrity in modern culture through a detailed case study of gay subcultural receptions of female stardom. The female star or ?diva? has been an influential figure in gay subcultures since the nineteenth century where it has inspired significant and enduring productions of gay selfhood. The project explores the histories of gay ?diva worship? to analyse the role and uses of stardom in formati ....Consuming Celebrity: Female stardom and gay subcultural reception. This project explores the function of celebrity in modern culture through a detailed case study of gay subcultural receptions of female stardom. The female star or ?diva? has been an influential figure in gay subcultures since the nineteenth century where it has inspired significant and enduring productions of gay selfhood. The project explores the histories of gay ?diva worship? to analyse the role and uses of stardom in formations of cultural identity. Through scholarly publications, the study will make major contributions to our understanding of not only gay culture and history, but the significance of celebrity in modern cultural life.Read moreRead less
Building An Immunocompetent Alzheimer’s Disease Brain-on-a-chip
Funder
National Health and Medical Research Council
Funding Amount
$458,937.00
Summary
New human cell culture models of Alzheimer's disease are urgently needed to help translate drugs into successful patient outcomes. In this proposal we will develop an Alzheimer's disease brain-on-a-chip that contains the major human brain cell types and neuropathological features of the Alzheimer's. We will demonstrate the applicability of the model for identifying new Alzheimer's disease drugs and diagnostics and show that the model can be readily adopted by Australian Alzheimer's researchers.
Emotionally traumatic experiences are well remembered and, in some instances, frequent reminders of these events can lead to the development of fear-related anxiety disorders such as phobia or post-traumatic stress disorder (PTSD). The experiments outlined in this proposal will examine how a novel epigenetic mechanism of gene regulation contributes to the transition from the retrieval of a fear memory to its inhibition through a process called extinction.
There is an urgent need for engineered tissue repair and replacement components for cartilage implantation in damaged joints due to a shortage of donor tissue. This project will generate smart composite biomaterials with enhanced mechanical strength and physical properties that are desirable for cartilage repair. The fabricated scaffolds will mimic the microstructure of native cartilage and are next-generation biomaterials designed to facilitate cartilage regeneration.