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Novel antimicrobial target discovery by an integrated approach. The project aims to uncover the molecular targets of BDM-I, a novel antimicrobial candidate discovered by the start-up Australian company BioDiem Ltd. BDM-I is active against many drug resistant bacterial and fungal microorganisms and it is currently in pre-clinical development. However, the lack of resistant phenotypes makes it difficult to identify BDM-I’s mechanism of action. The project plans to use an integrated approach that c ....Novel antimicrobial target discovery by an integrated approach. The project aims to uncover the molecular targets of BDM-I, a novel antimicrobial candidate discovered by the start-up Australian company BioDiem Ltd. BDM-I is active against many drug resistant bacterial and fungal microorganisms and it is currently in pre-clinical development. However, the lack of resistant phenotypes makes it difficult to identify BDM-I’s mechanism of action. The project plans to use an integrated approach that combines a novel technique of in silico screening with experimental validation. Project outcomes are anticipated to include the first computational method to integrate target and ligand similarity for proteome-scale target and off-target discovery, which will advance the global fight against drug-resistant microorganisms.Read moreRead less
Grey literature, policy innovation and access to knowledge: realising the value of informal publishing. This project examines the growth of informal research publishing, 'grey literature' in Australia, and the policies and practices that shape it. The project will make recommendations for producers, collecting institutions and policy-makers on how to maximise the considerable social and cultural benefit of 'grey literature'.
Elucidating the increasing demand for genital cosmetic surgery among girls and women in Australia. This project will identify the psychosocial context of and public communication about the dramatic rise in female genital cosmetic surgery in Australia. Results will contribute to programs for sexuality and body image education, public health campaigns about normal genital diversity, and professional development for doctors and beauty therapists.
Attraction and retention: the role of mobility in educational pathways and human capital development. This project will examine the factors that attract and retain school leavers and tertiary graduates in cities, towns and rural areas of non-metropolitan Victoria. It will increase understanding of how spatial mobility shapes young people's transition through higher education to adulthood and guide regional development policy to enhance human capital.
Evaluating the effectiveness of fire safety programs in emergency services management. Measuring the effectiveness of fire safety programs is critical to minimising economic costs, optimising resource utilisation and mitigating risk to individuals of injury and death. This project will be the first study to develop a methodological framework that integrates geographical, statistical and temporal analyses for their evaluation.
Discovering a ‘good read’: Pathways to reading for Australian teens. This project aims to support the school, library, and book industries to increase teenagers’ recreational reading. Matching the right book to the right reader is essential to increase young people’s motivation to read. Yet how cultural intermediaries should operate to best effect within the complex ecologies that shape young people’s text selection is unclear. The project expects to generate robust evidence on how teens discove ....Discovering a ‘good read’: Pathways to reading for Australian teens. This project aims to support the school, library, and book industries to increase teenagers’ recreational reading. Matching the right book to the right reader is essential to increase young people’s motivation to read. Yet how cultural intermediaries should operate to best effect within the complex ecologies that shape young people’s text selection is unclear. The project expects to generate robust evidence on how teens discover books and the cultural factors that influence their choices. Expected outcomes include strategies that libraries, schools, and the book industry can use to promote Australian content for young adults, and equip young people to participate more fully in the social and economic benefits of pleasure reading.Read moreRead less
Digital Labour, Australian Women Authors, and Public Persona-Building . Women authors are vital to Australia’s creative economy and cultural life. To ensure their wider cultural resonance as well as commercial success, such authors have long been actively engaged in the business of image management. However, digital media have significantly altered how renown is manufactured and sustained, in ways that are yet to be understood in the Australian context. Generating new knowledge about the role of ....Digital Labour, Australian Women Authors, and Public Persona-Building . Women authors are vital to Australia’s creative economy and cultural life. To ensure their wider cultural resonance as well as commercial success, such authors have long been actively engaged in the business of image management. However, digital media have significantly altered how renown is manufactured and sustained, in ways that are yet to be understood in the Australian context. Generating new knowledge about the role of digital media in promoting women authors, this project's findings will be of use to authors, publishers, cultural policy makers and funding bodies to help better support these vital cultural workers in their digital media usage.Read moreRead less
Engaging ethnic minority and majority blood donors in donor recruitment. Word-of-mouth is a potentially powerful way to recruit blood donors. Talking about donation increases awareness, trust, commitment and positive feelings about donating, particularly in ethnic minority groups. However, donors seldom tell others about donating. This project aims to determine how to motivate blood donors to recruit new donors using word-of-mouth, through research comprising co-design, surveys, and experiments. ....Engaging ethnic minority and majority blood donors in donor recruitment. Word-of-mouth is a potentially powerful way to recruit blood donors. Talking about donation increases awareness, trust, commitment and positive feelings about donating, particularly in ethnic minority groups. However, donors seldom tell others about donating. This project aims to determine how to motivate blood donors to recruit new donors using word-of-mouth, through research comprising co-design, surveys, and experiments. This project will generate new knowledge of how to encourage effective word-of-mouth for pro-social behaviours. Expected outcomes include producing culturally relevant, validated resources that will significantly benefit Australia by encouraging effective conversations to promote blood donation in all communities.Read moreRead less
Designing dendrimer-based lymphatic drug vectors as improved treatments for metastatic cancer. This project builds on areas of research strength in Australia (nanotechnology and biotechnology/biomaterials) and will add considerably to the expanding Australian expertise-base in dendrimer technology (in which it is a world leader). The project will advance the fundamental science base that underpins dendrimer design and has the potential to deliver substantial benefits in improved drug delivery an ....Designing dendrimer-based lymphatic drug vectors as improved treatments for metastatic cancer. This project builds on areas of research strength in Australia (nanotechnology and biotechnology/biomaterials) and will add considerably to the expanding Australian expertise-base in dendrimer technology (in which it is a world leader). The project will advance the fundamental science base that underpins dendrimer design and has the potential to deliver substantial benefits in improved drug delivery and therefore health outcomes for Australia. The interdisciplinary nature of this project will also result in a unique training program for the researchers involved. Such experience is in great demand in Australia where the developing biotechnology and nanotechnology industry is critically short of scientists with skills in drug delivery.Read moreRead less
Valuing Web Series: Economic, Industrial, Cultural and Social Value. This project investigates the value of web series as a form of online screen entertainment characterised by original and diverse content produced by emerging creatives. It will deploy the theoretical frame of ‘total value’ to assess the role and viability of web series: value accrued as career development opportunities for digital content makers; value accrued by the audiences who consume web series; and the value accrued by t ....Valuing Web Series: Economic, Industrial, Cultural and Social Value. This project investigates the value of web series as a form of online screen entertainment characterised by original and diverse content produced by emerging creatives. It will deploy the theoretical frame of ‘total value’ to assess the role and viability of web series: value accrued as career development opportunities for digital content makers; value accrued by the audiences who consume web series; and the value accrued by the Australian screen industry as web series contribute to innovation in a rapidly evolving global screen ecology. We have partnered with four leading web series festivals who will benefit directly from a hosting a number of forums for the discussion and dissemination of our comparative findings.Read moreRead less