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Education reform and social transformation in rural China. This project will increase Australian understanding of China's transformation from a rural, agricultural nation into an urban industrialized one. It will also build a collaboration between the Australian National University and the Shandong Academy of Social Sciences, which will facilitate the ability of Australian postgraduate students to undertake field research in China.
Enlightened Explorations?: Revisioning Gender and Sexuality in British and French Exploratory Voyages of the Pacific. This project aims to compare the representations of gender and sexuality on British and French exploratory voyages of the Pacific from the late eighteenth to the mid- nineteenth century. Starting from the islands of Samoa (Tcherkézoff ) and Vanuatu (Jolly), we will consider the centrality of gender and sexuality in categorizations of different ?races? or ?nations? and especially ....Enlightened Explorations?: Revisioning Gender and Sexuality in British and French Exploratory Voyages of the Pacific. This project aims to compare the representations of gender and sexuality on British and French exploratory voyages of the Pacific from the late eighteenth to the mid- nineteenth century. Starting from the islands of Samoa (Tcherkézoff ) and Vanuatu (Jolly), we will consider the centrality of gender and sexuality in categorizations of different ?races? or ?nations? and especially the distillation of the contrast between Polynesia and Melanesia. These voyages were foundational not just for enduring European visions of the Pacific but for Islander perceptions of and relations with Europeans, and later transformations of indigenous patterns of gender and sexuality.Read moreRead less
Conductance states of a brain glutamine transporter. Brain transporters are the target for many neuroactive drugs that are used to treat anxiety, depression and other psychotic disorders. Transport processes are also targeted to deliver neurotransmitter precursors to the brain to treat disorders such as Parkinson's disease. In this project we will study a transport process crucial for the function of neurons that release glutamate and GABA (gamma-aminobutyric acid) as neurotransmitters. The stud ....Conductance states of a brain glutamine transporter. Brain transporters are the target for many neuroactive drugs that are used to treat anxiety, depression and other psychotic disorders. Transport processes are also targeted to deliver neurotransmitter precursors to the brain to treat disorders such as Parkinson's disease. In this project we will study a transport process crucial for the function of neurons that release glutamate and GABA (gamma-aminobutyric acid) as neurotransmitters. The study of this transport process will be important for understanding disorders like epilepsy and other disorders affecting neuronal excitability.Read moreRead less
Identification of structural proteins in the tissue cyst wall of Toxoplasma gondii. Most infections with Toxoplasma gondii are asymptomatic, however, infection during pregnancy can lead to miscarriage or blindness, deafness and mental retardation in the developing baby. Furthermore, in AIDS patients, toxoplasmosis is the leading cause of fatal encephalitis as the normally dormant tissue cysts are reactivated in the absence of an effective immune system. In Australia, it has been estimated that ~ ....Identification of structural proteins in the tissue cyst wall of Toxoplasma gondii. Most infections with Toxoplasma gondii are asymptomatic, however, infection during pregnancy can lead to miscarriage or blindness, deafness and mental retardation in the developing baby. Furthermore, in AIDS patients, toxoplasmosis is the leading cause of fatal encephalitis as the normally dormant tissue cysts are reactivated in the absence of an effective immune system. In Australia, it has been estimated that ~30% of the population is infected with T. gondii and the occurrence of congenital toxoplasmosis is 0.2% of live births, which translates to roughly 500 cases/year. Our research will identify structural proteins in Toxoplasma cyst walls that will lead to the design of new strategies to control the diseases caused by these parasites.Read moreRead less
Single Molecule Studies of Replisomal Function. It has recently become possible to watch the copying of DNA molecules with a specialized microscope in real time. This process requires assembly of a complex molecular machine on the DNA, followed by triggering of its function, and yields exquisitely detailed information about how the machine works. In this new collaboration between scientists in Australia and the U.S.A., we will assemble these machines on single DNA molecules, watch how they work ....Single Molecule Studies of Replisomal Function. It has recently become possible to watch the copying of DNA molecules with a specialized microscope in real time. This process requires assembly of a complex molecular machine on the DNA, followed by triggering of its function, and yields exquisitely detailed information about how the machine works. In this new collaboration between scientists in Australia and the U.S.A., we will assemble these machines on single DNA molecules, watch how they work and simultaneously measure the very small forces that the machines generate. This will give Australian scientists access to a new technology for studying molecular machines.Read moreRead less