Development of disulphide-rich peptides for drug design. Peptides are an outstanding source of potential drug leads. This project seeks to build on earlier breakthroughs by developing stable, peptide-based drugs to combat cancer and autoimmune diseases. The peptides, derived from natural sources, are anticipated to provide drug leads that can ultimately lead to treatments for these diseases.
Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect ....Nanoparticles to combat cellular dysfunction. This project aims to design, synthesise and characterise nanoparticles that can mediate the adverse effects of reactive oxygen species. The project expects to develop nanoparticles with tailored chemical functionality to modulate the concentration of reactive oxygen species and develop a platform technology for addressing conditions where reactive species are overproduced. The project will research how nanoparticles’ physicochemical properties affect their activity, and how they affect cellular function, tissue morphology and particle transport in a biological milieu. The project is expected to benefit the advanced manufacturing, veterinary and medical sectors and could lead to new chemotherapeutics.Read moreRead less
Carbohydrates and Carbohydrate-Recognising Proteins as Drug Discovery Targets. The significance and roles of carbohydrates in many biological processes, in particular those processes associated with disease, is now well-recognised. These new directions have captured the attention and imagination of not only academic research groups across the world, but also pharmaceutical and biotechnology companies and has restimulated their interest in the pursuit of carbohydrate-based drugs and drugs against ....Carbohydrates and Carbohydrate-Recognising Proteins as Drug Discovery Targets. The significance and roles of carbohydrates in many biological processes, in particular those processes associated with disease, is now well-recognised. These new directions have captured the attention and imagination of not only academic research groups across the world, but also pharmaceutical and biotechnology companies and has restimulated their interest in the pursuit of carbohydrate-based drugs and drugs against carbohydrate-recognising proteins critical in disease processes. The current application seeks to use some of this information to faciliate the discovery of novel carbohydrate-based chemical entities as inhibitors of the spread of some cancers and diseases caused by pathogenic microorganisms.Read moreRead less
Reconceptualising industry sector development within the contemporary Australian city: The case of the information technology sector. This project will aim to uncover the reasons why Australia's Information Technology industry is ranked low among OECD countries by evaluating the impact of global and urban geography of the sector on the sector's performance. It will show how policies to achieve more advanced IT sector development need to consider Australia's distinctive position in the global eco ....Reconceptualising industry sector development within the contemporary Australian city: The case of the information technology sector. This project will aim to uncover the reasons why Australia's Information Technology industry is ranked low among OECD countries by evaluating the impact of global and urban geography of the sector on the sector's performance. It will show how policies to achieve more advanced IT sector development need to consider Australia's distinctive position in the global economy and particular factors in the Sydney and Melbourne IT clusters that both help, and hinder, development in ways not considered in present policy models.Read moreRead less
Special Research Initiatives - Grant ID: SR0354576
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Spatially Integrated Social Science Research in Australia. Rapid change across society has resulted in shifts to the scope of social science research including the emergence of space and place as an important concept. Across research fields the result has been that a range of innovative and unique techniques, methodologies and theories that are space based are now being developed. While research is progressing rapidly, it is undertaken in parallel by researchers who can not always collaborate. ....Spatially Integrated Social Science Research in Australia. Rapid change across society has resulted in shifts to the scope of social science research including the emergence of space and place as an important concept. Across research fields the result has been that a range of innovative and unique techniques, methodologies and theories that are space based are now being developed. While research is progressing rapidly, it is undertaken in parallel by researchers who can not always collaborate. Recognising these advances, this initiative focuses on harnessing Australia's capacity and potential in the use of spatially based methods and theories and brings researchers together in collaboration across a number of fields. Read moreRead less
ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial ....ARC Research Network in Spatially Integrated Social Science. The ARC Research Network in Spatially Integrated Social Science (SISS) builds Australia's capacity and capability for innovative, collaborative, cross-disciplinary effort to investigate the impacts of change on the behaviour and well-being of people and the fortunes of places. SISS theories and research tools permit the integration of diverse and complex databases, the generation of new synthetic datasets, the incorporation of spatial concepts into statistical analysis and modelling, powerful visualisation of information, and the building spatial decision support systems, to provide an improved evidence base and better informed decision-making to address the significant challenges facing Australia's people and its places.Read moreRead less
Barriers and Facilitators of Neighbourhood Networks and Cohesion. Neighbourhoods are critical contexts for health, safety and well-being. In the face of significant urban growth, understanding and enhancing neighbourhood networks and cohesion are high priorities in Australia and internationally. Drawing on longitudinal survey data from 148 Brisbane suburbs combined with census and spatial data, this project will be the first to examine how a neighbourhood's physical and socio-structural context ....Barriers and Facilitators of Neighbourhood Networks and Cohesion. Neighbourhoods are critical contexts for health, safety and well-being. In the face of significant urban growth, understanding and enhancing neighbourhood networks and cohesion are high priorities in Australia and internationally. Drawing on longitudinal survey data from 148 Brisbane suburbs combined with census and spatial data, this project will be the first to examine how a neighbourhood's physical and socio-structural context influences neighbourhood networks and cohesion over time and across the landscape of an entire city. The project aims to advance scientific understanding of neighbourhood networks and cohesion, provide unique insights into its underpinning drivers, and inform urban policy.Read moreRead less
Special Research Initiatives - Grant ID: SR0567196
Funder
Australian Research Council
Funding Amount
$55,000.00
Summary
Improved early detection of breast cancer enabled by grid-computing and advanced modelling and visualisation of MR images. This project will investigate the utility of grid computing in the detection of breast cancer from magnetic resonance (MR) images. The large quantity of data acquired using MR imaging is difficult for clinicians to review and the cost of missed or incorrect detection is high. To provide rapid visualisation and assessment of the acquired data, grid computing will be used in c ....Improved early detection of breast cancer enabled by grid-computing and advanced modelling and visualisation of MR images. This project will investigate the utility of grid computing in the detection of breast cancer from magnetic resonance (MR) images. The large quantity of data acquired using MR imaging is difficult for clinicians to review and the cost of missed or incorrect detection is high. To provide rapid visualisation and assessment of the acquired data, grid computing will be used in conjunction with interactive visualisation with haptic feedback. Grid computing experience and haptic device expertise will be achieved via Swedish collaborators. The successful outcome of this project will be software for the production of 3D colour-coded breast images in which suspicious regions are highlighted and can be physically interrogated using the haptic device.Read moreRead less
Attraction and retention: the role of mobility in educational pathways and human capital development. This project will examine the factors that attract and retain school leavers and tertiary graduates in cities, towns and rural areas of non-metropolitan Victoria. It will increase understanding of how spatial mobility shapes young people's transition through higher education to adulthood and guide regional development policy to enhance human capital.
Evaluating the effectiveness of fire safety programs in emergency services management. Measuring the effectiveness of fire safety programs is critical to minimising economic costs, optimising resource utilisation and mitigating risk to individuals of injury and death. This project will be the first study to develop a methodological framework that integrates geographical, statistical and temporal analyses for their evaluation.